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Biomedical subjects

F E Gorbacheva

Publications and source records attributed to F E Gorbacheva.

13 recordsLinked to original sources
PubMed1992

[Carotid artery hemodynamics during increased arterial blood pressure].

Ultrasonic duplex scanning was used to measure the volumetric rate of the blood flow (VRBF) in the common carotid artery (CCA) during arterial pressure (AP) rise in 46 patients suffering from arterial hypertension. The group of patients (n = 27) with a moderate rise of AP (by 10-20% of the common AP values) did not manifest any changes in the VRBF in the CCA during AP rise. In the group of patients with a considerable rise of AP (by more than 20% of the common AP values), there was a significant (p less than 0.01) decrease of the total VRBF in both CCA to 747.6 +/- 34.6 ml/min in AP rise as compared with the VRBF in common AP values--815.6 +/- 37.2 ml/min. Apparently, cerebral complaints in the majority of cases of AP rise are not due to excess blood inflow to the brain; the rise of vascular cerebral resistance associated with AP elevation may be of importance.

Adult↗
PubMed1991

[Evaluation of the functional state of the peripheral motor neuron apparatus in patients with diabetes mellitus].

As many as 84 patients suffering from diabetes mellitus with and without clinical manifestations of diabetic neuropathy (DN) underwent clinical and electromyographic examinations. The patients with clinical manifestations of DN showed a decrease of the rate of wave spreading in the distal and proximal parts of lower limb nerves, an increase of the proximal distal gradient, a decline of the amplitude of the maximal M-response, an increase of the latent period or the lack of H-reflex. The data point to generalized impairment of the peripheral neuromotor apparatus with primary involvement into the process of the distal parts of limb nerves. In the majority of the patients without clinical manifestations of DN, electromyography also demonstrated injury to the peripheral nerves, evidence of a possibility of electromyographic diagnosis of the subclinical stage of DN.

Adolescent↗
PubMed1991

[Informative value of complex electromyographic and immunologic examinations of patients with diabetic neuropathies].

As many as 43 patients suffering from diabetes mellitus associated with the clinical manifestations of diabetic neuropathy underwent ++clinico-electromyographic and immunologic examinations. The control group comprised 30 practically healthy persons of the same age. The electromyographic++ examination included measurements of the rate of wave spreading in motor fibers of the limb nerves in the distal and proximal parts (in accordance with the F-wave), a study of H-reflex from the musculus soleus of the leg together with M-response of hand and foot muscles. The immunologic examination consisted in measurements of different class immunoglobulins in the blood serum. Based on the electromyographic findings, 3 groups of patients were distinguished: group I included patients with primary injury to the myelin membrane of the nerves; group II was made up of patients with primary injury to the axon, and group III of patients with concomitant injury to the nervous membranes and axons. There was a significant elevation of the concentration of anti-myelin activity possessing IgM in the blood serum of patients belonging to groups I and III, which attests to the involvement of the immunopathological mechanism into myelopathy development.

Adult↗
PubMed1991

[Volumetric blood flow in the carotid arteries in various forms of cerebrovascular pathology (based on data from two-dimensional Doppler ultrasonography)].

A total of 86 patients with a history of insult in the carotid system and 105 patients with the early clinical forms of cerebrovascular pathology (ECFCVP) were examined for the volumetric blood flow in the general carotid artery (GCA) using two-dimensional dopplerography. In the group of insult patients, the total volumetric blood flow in bot carotid arteries decreased by 13% on the average, in the group with ECFCVP by 8% as compared to the group of healthy persons. The decrease of the blood flow was recorded not only in the presence but also in the lack of the stenosing process in the carotid arteries.

Adult↗
PubMed1990

[Comparative evaluation of drugs used in the treatment of brain edema in cerebral stroke and their effects on cerebral blood flow].

Altogether 102 patients with grave cerebral stroke were examined for the efficacy of the treatment of brain edema with lasix, mannitol+, glycerol and dexamethasone and for the influence of the drugs on the rheological blood properties. Blood osmolality was studied depending on the time elapsed since the moment of stroke as were its changes after administration of the osmoactive substances (mannitol+, glycerol). Analysis of the data obtained indicates that dexamethasone and glycerol produce the highest clinical effect together with a favourable influence on the rheological blood properties. The use of lasix and mannitol+ did not produce any positive clinical effect. At the same time lasix was noted to exert an untoward effect on the rheological blood properties. The conclusion is made that combination of dexamethasone and glycerol is advisable in the treatment of brain edema in patients with grave cerebral stroke.

Adult↗
PubMed1986

[Functional status of spinal motoneurons in patients with acute cerebral circulatory disorders].

The article presents the results of clinico-electromyographic examinations of 75 patients with a history of acute impairment of circulation in the carotid system. The study revealed differences in changes in the antidromic excitability of spinal motoneurons as judged from the amplitude parameters of the F wave in relation to the time elapsed from the moment of the stroke and to the nature of neurologic disturbances. Examination of the F wave is shown to be informative in monitoring the recovery of motor functions.

Acute Disease↗
PubMed1977

[Prognosis of transient disorders of cerebral circulation and risk factors in the development of stroke].

The paper is concerned with the results of a study of 140 patients who had had transient disorders of cerebral circulation. Among these cases 47 were subjected to a prospective observation and 93 to a retrospective one. The authors analyse 32 possible risk factors of brain stroke in patients with transient disorders of cerebral circulation. Their mathematical processing was accomplished with the aid of correlational coefficients and conditioned probabilities, detecting the highest pathogenic importance of these factors (such as disturbance of the rhythm of cardiac activity, arterial hypertension higher than 190 mm, etc). A mathematical evaluation and combination of factors was made. It was demonstrated that there is a diminution of the risk of development of ischemic stroke with development of parkinsonism in patients with transient disorders of cerebral circulation. The authors give recommendations for prophylactic treatment in order to prevent strokes in this group of patients.

Adult↗