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Biomedical subjects

F E Offeciers

Publications and source records attributed to F E Offeciers.

8 recordsLinked to original sources
PubMed1990

The solitary schwannoma of the eighth cranial nerve. An immunohistochemical study of the cochlear nerve-tumor interface.

Given recent controversy concerning hearing preservation surgery of the acoustic neurinoma, an immunohistochemical study was undertaken to investigate the cochlear nerve-tumor interface. Ten intact medium-sized acoustic neurinomas were studied by means of classic staining procedures and an immunohistochemical technique using monoclonal mouse antibodies to human neurofilaments. Our observations indicate that the cochlear nerve is histologically involved in the tumoral process in those cases in which macroscopically visible adherences between the cochlear nerve and the tumor are present. We were not able to discern a clear cleavage plane. Six of the 10 specimens showed tumoral invasion of the cochlear nerve. Several therapeutic attitudes are discussed in view of these observations and reports from the international literature. In conclusion, the principle of hearing preservation surgery is rejected in favor of total tumor removal in every case in which surgery is indicated.

Aged↗
PubMed1990

[Acoustic neuroma: a histopathological study].

In view of recent controversy concerning the preservation of hearing in acoustic neuroma surgery, a histologic study of the nerve-tumour interface was undertaken in order to investigate cochlear nerve involvement. Twelve intact acoustic neuromas were studied by means of Masson's trichrome stain, the Luxol fast blue technique, Verhoeff's stain and an immunohistochemical technique using monoclonal antibodies to human neurofilaments. In nine out of twelve specimens, macroscopically visible adherences were present between the cochlear nerve and the tumour. The microscopical correlate was found to be the absence of a clear cleavage plane between the cochlear nerve and the tumour on the one hand, and the presence of cochlear nerve fibers, surrounded by tumoural cells, past the assumed nerve-tumour interface on the other hand.

Cochlear Nerve↗
PubMed1989

Tuberculosis in the middle ear: 5 case reports.

Five cases of tuberculosis otitis media are reported. The clinical picture and the hazards of diagnosis are discussed. Although not a common cause of chronic otitis media, tuberculosis of the middle ear cleft is an entity one should recognize especially when a chronic suppurative ear disease does not respond to the usual treatment. The signs and symptoms are non-specific. Altering features include racial predisposition, contact or personal history of past or present tuberculosis, chronicity, development of a facial palsy and the pale granulation tissue found at the operation.

Antitubercular Agents↗
PubMed1985

The UIA-KUL cochlear implant. Goals and status praesens.

The authors describe the characteristics and specific advantages of their 8 channel bipolar intrascalar stimulator, its main asset being flexibility. They emphasize the need for caution in the use of cochlear implants in children.

Adult↗