Examination by scanning electron microscopy of erythrocytes from three cases of microangiopathic haemolytic anaemia demonstrated the presence of adherent cells. Although in some cases this appeared to be due to a thin strand, presumably fibrin, between the erythrocytes, in most instances there was intimate contact and this was invariably associated with damage to the red cell surface membrane. It is considered that the adherence is predominantly due to altered physico-chemical properties of the surface membrane of the red blood cell and that further morphological abnormalities may result from the intravascular stresses to which the paired cells are subjected.

Anemia, Hemolytic↗

PubMed1967

Paralleling in conservative dentistry. 3. The pontostructor.

Explore the source record for details and available documents.

Cementation↗

PubMedDate not supplied

Platelet function and coagulation in patients with hepatobiliary disorders receiving cefotetan prophylaxis.

Eighteen patients with hepatobiliary disorders undergoing invasive biliary tract investigations were given the cephalosporin cefotetan and platelet function and coagulation factors were monitored. No significant changes were observed in the group as a whole, although marked alterations were seen in three patients in association with clinical complications unrelated to the antibiotic. Although cefotetan is structurally similar to cephalosporins which have been associated with bleeding disturbances, it does not appear to induce such abnormalities in a high risk group of patients with normal renal function when given for five days intravenously at a dose of 1 g twice daily.

Adult↗

PubMedDate not supplied

Disorders of haemostasis in diabetes mellitus.

The frequent occurrence of vascular complications in diabetes mellitus has prompted extensive research into possible mechanisms which may relate to these complications. Recently, most emphasis has been directed towards the platelet and there is now good evidence of disordered platelet function, platelet biochemistry and platelet vessel wall interaction in many diabetic patients. In addition to these disturbances of platelet behaviour, other haemostatic abnormalities are not uncommon in the diabetic patient. These include evidence of coagulation activation, impaired fibrinolysis and altered blood viscosity. All of these changes could theoretically predispose to a thrombotic state, but the precise relationship between the observed abnormalities and the development and progression of the vascular complications remains to be established.

Blood Coagulation↗

PubMedDate not supplied