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Biomedical subjects

F E Rosato

Publications and source records attributed to F E Rosato.

At least 19 recordsLinked to original sources
PubMed1991

Adenocarcinoma of the pancreas: a multimodality approach--a single surgeon's experience (1979-1988).

A retrospective review of a single surgeon's experience with adenocarcinoma of the pancreas was performed. One hundred-one patients were treated over a 10-year period from 1979 to 1988. Seven patients underwent potentially curative resections and 28 patients presented with metastatic (stage IV) disease. Sixty-four patients had locally advanced and unresectable primary lesions. A total of 51 patients received I-125 seed implantation. There was no statistically significant difference in morbidity (33% vs. 30%) or mortality (6% vs. 8%) between patients receiving I-125 implantation and those undergoing palliative surgical procedures without implantation. Operative mortality was highest in patients presenting with stage IV lesions (11%). In those patients with locally advanced and unresectable carcinomas, there was a nonsignificant increase in survival (12.8 mo vs. 10.7 mo) in those receiving intraoperative I-125 implants when compared to those who did not when both groups received postoperative adjuvant chemotherapy and external beam radiotherapy. Based on these encouraging results, it is concluded that I-125 implantation can be performed safely and shows a trend toward improving long-term survivorship in patients with locally advanced pancreatic carcinoma when used in conjunction with chemotherapy and external beam radiation.

Actuarial Analysis↗
PubMed1990

Selective arterial stimulation of secretin in localization of gastrinomas.

In two patients with malignant gastrinoma and the Zollinger-Ellison syndrome, we were able to use selective arterial stimulation with secretin as a technique to localize the lesions accurately, allowing resection. The technique of selected arterial secretin stimulation is one of measuring variations in gastrin levels in both the hepatic vein and a peripheral artery at specified times after injection of secretin into a specific artery. When the criteria for localization have been met, one can plot the presence of the gastrinoma within the blood supply of the injected artery and, using angiograms, thus accurately localize the lesion. This method promises to be a valuable additional tumor-localizing procedure, particularly when gastrinomas are extrapancreatic.

Adenoma, Islet Cell↗
PubMed1985

Impact of radiotherapy on palliative gastroenterostomy in pancreatic cancer.

The previously unaddressed impact of radiotherapy and vagotomy on palliative gastroenterostomy (GE) in patients with unresectable pancreatic cancer was studied. Sixty-eight patients were retrospectively evaluated. A higher overall incidence of complications was found in the group (N = 44) undergoing irradiation as well as gastroenterostomy compared to a group undergoing gastroenterostomy alone. The increased complications were due to 16 episodes of bleeding among the irradiated patients. Rates of obstructive complications were similar for both groups (20%). Rates of bleeding were highest among patients undergoing prophylactic GE and irradiation compared to those receiving GE alone. Vagotomy in 12 patients who were irradiated did not appear to protect against bleeding. We found the irradiated prophylactic GE to provide poor palliation in patients with unresectable pancreatic cancer and recommend it not be performed if radiotherapy is to be used for attempt in local control of unresectable pancreatic cancer.

Adult↗
PubMed1979

Achalasia of the esophagus associated with Hodgkin disease.

Esophageal achalasia has not been reported in the literature as a complication of Hodgkin disease. Involvement of the esophagus is rare but when present, consists mostly of bleeding, ulceration or diverticuli. A case is reported in a fifty-one year old female with achalasia of the distal third of the esophagus associated with Hodgkin disease, Stage II B.

Esophageal Achalasia↗
PubMed1979

Leukocyte migration inhibition assay in patients with bladder cancer.

The leukocyte migration inhibition assay has demonstrated successfully tumor-associated antigenic activity in protein extracts of cell culture lines of a number of neoplasms. Our data have shown a high degree of leukocyte migration inhibition reactivity with protein extracts from the well characterized T-24 transitional carcinoma cell line. Thus, the leukocyte migration inhibition assay may prove a valuable method of in vitro assessment of the cell-mediated immunity of bladder cancer patients and as a method to monitor attempts at further purification of tumor-associated antigens.

Antigens, Neoplasm↗
PubMed1979

Effect of gastrin on the exocrine pancreas. A review.

Studies in animals demonstrate a gastric hormonal phase of pancreatic exocrine secretion. Endogenous or exogenous gastrin causes a marked elevation in the pancreatic enzymes and a lesser increase in the pancreatic volume and bicarbonate. It is possible that these "gastrin" effects may be the basis of a "cephalic" phase of pancreatic secretion. These observations have been only partially confirmed in human subjects with and without the Zollinger-Ellison syndrome. The physiologic importance of these ecbolic actions as well as a possible trophic effect remains to be elucidated.

Animals↗
PubMed1979

Smooth muscle tumors of the stomach and small bowel.

Smooth muscle tumors of the stomach and small bowel, although rare, have a favorable prognosis when recognized and treated promptly. This review of 33 patients with leiomyoma, leiomyblastoma, or leiomyosarcoma of the stomach and small intestine reveals that all but two were treated by resection of the tumor, with good results.

Adult↗
PubMed1979

Reconstruction of the breast after mastectomy for cancer.

General surgeons are taking a more active role in the treatment of all the problems which face the patient who undergoes mastectomy. For many of these women, an important part of their adjustment is achieved by reconstruction of the breast. The number of women requesting reconstruction of the breast after mastectomy is increasing, and more women faced with mastectomy are asking their general surgeons for information about the procedure. It is hoped that as reconstruction of the breast becomes more widely appreciated, women will be encouraged to perform more frequent self-examinations and to seek earlier treatment of carcinoma of the breast. It is tempting to speculate that one ultimate benefit may be an improvement in the survival figures associated with this disease.

Breast↗
PubMed1979

Malignant melanoma--an overview.

We have presented our experience in light of current practice in the management of malignant melanoma. Central to considerations of adequate management is the question of precise definition of the extent of the disease as determined by histologic evaluation, determination of the depth of penetration and assessment of the extent of spread. Wide surgical excision remains the most important consideration with perfusion therapy, in our view playing a key role in the management of extremity melanoma. Encouraging data for adjuvant immunotherapy continues to unfold. We present here a rational approach to diagnosis and management of malignant melanoma.

Female↗
PubMed1978

Serum fucose as a monitor for recurrent malignancy.

Serum fucose determinations were performed on 19 patients with "stable" or "inactive" malignancies, 33 patients with "active" malignancies, and 14 "normals." A significant difference in the values between "normal" and "stable" patients and those with "active" cancer is shown. A role for this relatively simple serological test for diagnosing and following metastatic cancer is suggested.

Adult↗
PubMed1978

Primary malignant hemangioendothelioma of the liver: survival following nonoperative treatment.

A case of primary hemangioendothelioma is presented. Following autodearterialization, the patient received 5-fluorouracil orally and total hepatic radiation. To date, 30 months later, he remains alive and active with residual hepatic defect on liver scan, but no indication of progression of disease. Primary malignant hemangioendothelioma is discussed briefly in terms of etiology, pathology, diagnosis, and treatment, and a treatment plan is presented. This case also presented an unusual side effect of 5-fluorouracil therapy -- mononeuritis multiplex -- and is presented out of interest.

Fluorouracil↗
PubMed1978

Cell-mediated immunity in patients with renal cell carcinoma as measured by leukocyte migration inhibition test.

The cell-mediated immune (CMI) response to tumor-associated antigens present in 3 M KCL extracts of renal cell carcinoma tissue was measured in patients with renal cell carcinoma (RCC) by the leukocyte migration inhibition (LMI) test. Of 30 patients with histologically proved RCC, 19 (63%) gave a positive LMI test; whereas, 2 of 28 (7%) of the normal donors, 13 of 43 (30%) patients with other cancers, and 5 of 14 (36%) benign kidney disease patients gave positive tests. Thirteen per cent of RCC patients reacted to a normal kidney extract. Although 33% gave a positive response to a lung carcinoma extract, the incidence of reactivity was less than that observed with the lung cancer patients. These results suggest that a CMI response to a renal carcinoma-associated antigen was measured by the LMI test. Correlation of the LMI data with the stage of disease and clinical status indicated that 71% of patients that had a localized tumor and were clinically free of disease one year postnephrectomy lost their tumor-directed CMI response. Patients with distant metastasis (Stage D) were LMI positive provided they had not received radiation or hormone therapy at the time of testing. These results suggest that the demonstration of CMI, as measured by the leukocyte migration inhibition test, correlates with the presence of active disease.

Adenocarcinoma↗
PubMed1978

Postmastectomy reconstruction.

Reconstructive surgery following mastectomy has had an increased acceptability with improved techniques and prostheses. Plastic reconstructive procedures following prophylactic mastectomy were performed in 104 patients and following mastectomy for cancer in 88 patients. Capsular contractions have not occurred with the use of a subpectoral pocket and detection of recurrent cancer is not hampered by the materials now used.

Breast↗
PubMed1978

Silicone prostheses and anti-tumor immunity: an in-vitro rat study.

We believe we have demonstrated that there is no difference in the immune responsiveness in normal animals which undergo sham surgery (as compared to those unoperated). With the addition of a simple placement of a silicone prosthesis, there was an increase in the lymphocyte cytotoxicity--but this was equalized by a blocking effect at both the target cell and the lymphocyte levels. This response appeared to be of short duration. The presence of tumor, as previously documented produces an increase in lymphocyte cytotoxicity with a concomitant increase in the target cell and the lymphocyte blocking effect. Importantly, we found no significant difference in the immune response when prostheses were placed as an adjunct to surgical excision of transplanted tumors in this rat model.

Animals↗