Biomedical subjects

F E Schmidt

Publications and source records attributed to F E Schmidt.

12 recordsLinked to original sources

PubMed1996

Leukocyte depletion of blood cardioplegia attenuates reperfusion injury.

BACKGROUND: Leukocytes are associated with myocardial injury during reperfusion after ischemia. Short periods of leukocyte depletion during reperfusion result in persistent attenuation of postischemic myocardial dysfunction. METHODS: Leukocyte depletion was examined in a canine model of regional myocardial ischemia and reperfusion. The extracorporeal circuit and cardioplegia circuits underwent leukocyte depletion by mechanical filtration. Animals were instrumented for baseline global function before 90-minute occlusion of the left anterior descending coronary artery. Global function during ischemia and at 5, 30, 60, and 90 minutes after a 60-minute cardioplegic arrest using continuous blood cardioplegia was assessed in leukocyte-depleted (n = 9) and control (n = 10) groups. RESULTS: No significant difference between groups was seen for systemic leukocyte counts, global function, or water content. Endothelial function was significantly protected as assessed by response to both calcium ionophore (endothelial-dependent, receptor-independent relaxation: leukocyte-depleted, 72% +/- 19% of endothelin-induced constriction versus control, 46% +/- 14%; p < 0.05) and acetylcholine (endothelial-dependent, receptor-dependent relaxation: leukocyte-depleted, 83% +/- 11% versus control, 44% +/- 15%; p < 0.05). CONCLUSIONS: Leukocyte-mediated endothelial reperfusion injury can be attenuated by leukocyte depletion during reperfusion.

Acetylcholine↗

PubMed1989

Differences in the household composition of elders by age, gender, and area of residence.

Using a new procedure for coding the relationships of elders to other household members, we examined age, gender, and area-of-residence differences in household type and generational composition. The majority of elders live in some form of family household; most prevalent are two-person, married-couple-only households at ages 65-79, one-person households at ages 80-89, and two-generation households at ages 90+. Overall, elders are more likely to live in two- than in three-generation households.

Age Factors↗

PubMed1980

Severe upper limb ischemia.

Severe upper limb ischemia is uncommon, and patterns typical of lower limb ischemia are seldom seen. The conditions of 31 patients with actual or threatened gangrene or severe disability were evaluated from 1969 through 1978. Causes of ischemia included emboli, arteriosclerotic occlusions, trauma, thoracic outlet compression, and small-artery occlusions associated with Raynaud's phenomenon, rheumatoid arthritis, or scleroderma. Five patients had emboli from lesions in peripheral arteries, and two patients had ulnar artery occlusions. Twenty-three patients had operations with no deaths. There was one operative failure. Operative angiograms were used routinely. Patients with emboli from the heart received heparin sodium after operation. Sympathectomy improved the conditions of two patients with Raynaud's phenomenon and of one patient with ulnar artery occlusion. One third of the patients had significant arteriosclerotic lesions in other locations.

Adolescent↗

PubMed1980

Aneurysm of anomalous right subclavian artery.

A 67-year-old man presented with a mediastinal mass and multiple arterial emboli to the right hand caused by an aneurysm of an anomalous right subclavian artery. Operative management was successful. We have reviewed other reported cases of this lesion.

Aged↗

PubMed1980