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Biomedical subjects

F Ebbesen

Publications and source records attributed to F Ebbesen.

At least 91 records · Page 5Linked to original sources

Gut transit time and lactose malabsorption during phototherapy. II. A study using raw milk from the mothers of the infants.

Thirty newborn infants with normal birth weight suffering from uncomplicated hyperbilirubinemia were studied. 15 infants received ordinary phototherapy and 15 intensive phototherapy (blue double light). All infants received their mothers' milk or fresh milk from mothers of other newborn infants of the same age. All infants had normal lactose tolerance test during the phototherapy, except one infant receiving ordinary transit time was relatively long. The gut transit time was significantly shorter in the infants treated with intensive phototherapy than in those treated with ordinary phototherapy without there being any significant difference in the increase in blood glucose by lactose tolerance tests. It is concluded that lactose malabsorption is not the usual cause of the reduced gut transit time during phototherapy even if the infants receive their mothers' milk.

Bilirubin↗

Late anaemia in infants with rhesus haemolytic disease treated with intensive phototherapy.

The purpose of the present study was to determine the incidence of late anaemia in infants with rhesus haemolytic disease (RHD) who had received intensive phototherapy. Sixty infants with RHD and with strongly positive direct Coombs' tests who had received intensive phototherapy (blue double light) were followed as out-patients with regard to development of late anaemia. Fifteen (25%) infants developed moderate anaemia and 5 (8%) severe anaemia, one of the latter requiring a blood transfusion. The incidence of late anaemia was equal in "non-exchanged" infants and those who required exchange transfusion. The former developed anaemia significantly earlier than the latter, and in both groups the declining Hb level caused a marked reticulocyte response which was equal in both groups. This response may explain the low incidence of anaemia in both the "non-exchanged" and "exchanged" infants. From the present study and previous investigations it can be concluded that phototherapy, especially intensive phototherapy, is of great value in the treatment of rhesus haemolytic disease.

Anemia, Neonatal↗

Post-tetanic mechanical tension and evoked action potentials in McArdle's disease.

The tension produced by the cramp evoked in the adductor pollicis muscle by repetitive stimuli to the nerve (20/s for 50 s) and by full voluntary effort in the brachial biceps was measured in a patient with McArdle's disease. The contracture was 17% of the peaktetanic tension, and was not associated with action potentials. Twitches superimposed on the contracture were at most diminished to half, as were their action potentials. Both slow and fast muscle fibres participated in the contracture. The contraction time of the twitches elicited after the tetanus was prolonged more in the patient than in a normal subject of the same age. There was evidence of delayed firing, first observed 90 seconds after the peak of the contracture. The patient had electromyographic and histological signs of myopathy.

Action Potentials↗

Agar ingestion combined with phototherapy in jaundiced newborn infants.

49 jaundiced, nonimmunized newborn infants with a birth weight of more than 2,000 g were given phototherapy with white light for more than 36 h. The average period of treatment was 61 h. 24 infants received 250 mg agar at the beginning of each meal at 3-hour intervals during phototherapy. 25 infants received phototherapy only. Serum bilirubin levels were decreased similarly in both groups. It is concluded that ingestion of agar does not supplement the effect of phototherapy.

Agar↗

Determination of serum bilirubin concentration during phototherapy of newborns and in vitro: results compared by the direct spectrometric method and the diazo method.

During direct illumination of a serum bilirubin solution the bilirubin concentration decreased markedly, both as determined by the direct spectrometric method and (even more so) by the diazo method. In contrast, I found the same values for serum bilirubin concentrations as determined by these two methods for serum from untreated, "single light", and "double light" treated full-term infants with neonatal hyperbilirubinemia without blood type immunization. The same was true for untreated and "single light" treated premature infants with this disease. Furthermore, no difference was found in the above-mentioned relationship between "single light" treated infants with the same disease, and untreated infants with neonatal hyperbilirubinemia without immunization, all born at term. This is important, because the direct spectrometric method is simpler and requires less serum than does the diazo method.

Azo Compounds↗

The relationship between the cephalo-pedal progress of clinical icterus and the serum bilirubin concentration in newborn infants without blood type sensitization.

The correlation between the cephalo-pedal progress of clinical icterus and the serum bilirubin concentration was examined in newborn infants without blood type sensitization. In daylight, 374 observations were made, 290 on 121 mature infants and 84 on 24 premature infants. The investigation showed that a caudad progress of icterus corresponded with an increasing serum bilirubin concentration, and repeated observations can demonstrate whether icterus progresses, showing that the concentration is increasing. The same relationship was found in respect of all the infants with the exception of the two smallest (birth weight less than or equal to 1000 g). They were icteric on the feet at lower concentrations than in the other infants. Furthermore, the relationship did not depend on which day the observations were made. It was not necessary to determine the bilirubin concentration until icterus had progressed to below the knees, as a concentration less than or equal to 110 mg/1 corresponded to all observations in which the lower limit of icterus was found proximal to the knees. However, in the small premature infants it would have been reasonable to measure the concentration when icterus had reached the area below umbilicus.

Antibody Formation↗