[Clinical studies with piracetam].
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Biomedical subjects
Publications and source records attributed to F Eckmann.
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In 1357 chronic hospitalized psychiatric patients (641 men and 716 women) aged between 40 and 69 years the mortality during 30 months was registered, referring for a prevalent study about riskfactors. The death rates for ischaemic heart diseases in hospitalized patients were 2,5-3,5 times as high as states in the statistic for total population of BRD. The majority of dead patients had two or more of the known riskfactors, more as the half of the dead patients had a manifest diabetes mellitus or a disorder of oral glucose tolerance test.
A statistically planned double blind cross-over test with the substances 1-[3-(10,11-dihydro-5H-dibenz[b;f]-azepin-5-yl)-propyl]-4-piperidino-piperidine-4-carboxamide dihydrochloride-monohydrate (carpipramine, BAY b 4343 b) and placebo (BAY b 4343 a) was carried out on 30 long-term hospitalized schizophrenic patients. The study was evaluated by means of the kappa2-test and yielded the following results: 1. It could be statistically proved that carpipramine has a positive effect on psycho-pathological disorders in the behaviour of long-term hospitalized schizophrenic patients (kappa2 = 9.224; FG = 1; p greater than 0.05). 2. As regards the favourable influence of carpipramine on "productive" versus "non-productive" form of schizophrenia there were no differences. 3. Side effects or complications of a psychic, autonomic and/or motoric manner could not be seen. The usual laboratory tests showed no deviation from normal.
1. An epidemiological research programme was carried out on a collective of 1752 psychotic patients from eight psychiatric hospitals during the period from October 1970 until February 1973. The possible relationships as to the intensity of pathological ECG changes and such factors as sex, age, the administration of tricyclic and non-tricyclic psychotropic agents with or without the combination of glycosides, the potency of neuroleptics and their clinical structure, were investigated. 2. No statistical significance could be established between pathological ECG changes and such factors as administration of tricyclic and non-tricyclic psychotropics with or without the combination of glycosides, or the potency of neuroleptics and their chemical structure. With a higher age the frequency of ECG changes increases independent on psychotropics. 3. The difficulties of interpretation, in particular regarding a generalisation of the results, are discussed.
Statistical methods seem to confirm the impression that a connection exists between the administration of neuroleptic drugs and a lowered cancer mortality rate. However, further analysis shows that the neuroleptic group and the controls represent two distinct populations which cannot be compared with each other.
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