Things start getting sticky for a cell surface enzyme.
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Animals↗
Biomedical subjects
F Eijgenraam
Publications and source records attributed to F Eijgenraam.
'Java Man' gains (and loses) a consort.
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Animals↗
Yeast chromosome III reveals a wealth of unknown genes.
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Chromosome Mapping↗
A window on life in the Bronze Age. The remains of a 4000-year-old man may shed light on the racial structure and culture of early Europe.
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Anthropology↗
Chernobyl's cloud: a lighter shade of gray.
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Accidents↗
Dutch AIDS researchers feel heat of publicity.
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Acquired Immunodeficiency Syndrome↗
Rapid change of the repertoire of variant surface glycoprotein genes in trypanosomes by gene duplication and deletion.
To study the evolution of the variant surface glycoprotein (VSG) repertoire of trypanosomes we have analysed the DNA region surrounding the VSG 118 gene in different trypanosome strains. We find a remarkable degree of variation in this area. Downstream from the 118 gene a 5.7 X 10(3) base-pair DNA segment containing a potential VSG gene has been quadruplicated in strain 427 of Trypanosoma brucei, but not in most other strains analysed. The VSG 1.1000 gene, located immediately upstream from the 118 gene in one trypanosome strain, has been cleanly deleted in another. Our results are most easily explained by multiple unequal cross-overs between sister chromatids and are the first indication that sister chromatid exchange occurs in trypanosomes.
Animals↗