Biomedical subjects
Publications and source records attributed to F F Vincieri.
Three novel polyhydroxylated triterpenes have been isolated from Uncaria tomentosa. Their structures were established as 1, 2, and 3 by detailed spectral studies including 1H-13C correlations via long range couplings using the INAPT pulse sequence, nOeds, and 2D 1H-13C direct chemical shift correlation (HETCOR) nmr techniques.
Psoralen was found to form an inclusion complex with beta-cyclodextrin (beta CD), heptakis(2,6-di-O-methyl)-beta-cyclodextrin (DM beta CD) and hepatakis(2,3,6-tri-O-methyl)-beta-cyclodextrin (TM beta CD). Phase solubility studies revealed the formation of a 1:1 molar complexes. The stability constant were 663 M-1 for beta CD, 603 M-1 for DM beta CD and 69.6 M-1 for TM beta CD. The formation of complexes in the solid state was confirmed by spectroscopic analyses, X-ray diffractometry and differential thermal data. The solubility and dissolution rate of the complexed forms were improved, particularly for the DM beta CD complex. The strength of binding of psoralen to DNA was not influenced by complexation with cyclodextrins.