Biomedical subjects

F Fallo

Publications and source records attributed to F Fallo.

112 records · Page 7Linked to original sources

PubMedDate not supplied

Adrenocortical carcinoma: experience in 45 patients.

Forty-five patients with adrenocortical carcinoma (13 nonfunctioning and 32 functioning carcinomas) were retrospectively studied. Five-year survival rate was 29% overall; for patients at stage I-II (n = 15) it was 70%, and for patients at stage III-IV (n = 30) it was 12%. In patients given mitotane + chemotherapy survival rate was similar to that observed in patients given chemotherapy alone, and significantly longer than in patients given mitotane alone (p < 0.05). There were no differences in disease-free interval and survival between adjuvant mitotane and no treatment. Optimization of therapeutic protocols in addition to early recognition may improve prognostic aspects of this type of malignancy for which treatment outcome is still unsatisfactory.

Adolescent↗

PubMedDate not supplied

[Role of aldosterone in the metabolic syndrome].

The purpose of this review is to summarize the current knowledge regarding metabolic syndrome prevalence and features in primary aldosteronism. We will also discuss the link between aldosterone and the different metabolic changes typical of the metabolic syndrome. Hypertensive patients have a high prevalence of obesity, dyslipidemia and hyperglycaemia. These are risk factors for the metabolic syndrome, and are associated with an increased cardiovascular risk profile. In particular, insulin resistance seems to be the major alteration in patients affected by primary aldosteronism. We will then describe the experimental and clinical evidences of the role of aldosterone in the pathogenesis of insulin resistance. Higher rates of cardiovascular events have been recently reported in primary aldosteronism: they could be partly due to the increased prevalence of the metabolic syndrome in this disorder.

Aldosterone↗

PubMedDate not supplied

Evaluation of percutaneous transluminal renal angioplasty in childhood hypertension.

Percutaneous transluminal renal angioplasty (PTRA) has been infrequently used in the treatment of children with hypertension due to renal artery stenosis. We report our results in five patients aged 4 to 22 years with hypertension diagnosed at ages 1 1/2 to 10 years. Four of the five patients had been on antihypertensive medication prior to angioplasty. Four had fibromuscular disease and one had probable Takajasu's arteritis; two had solitary kidneys. Following angioplasty, a prompt decrease in blood pressure was observed in all patients. Further, four of five patients after PTRA were normotensive without antihypertensive medications, and in all PRA declined. PTRA can be a safe and effective alternative to surgical treatment in the management of renovascular hypertension in childhood. We suggest that PTRA should be the first procedure attempted to correct renovascular hypertension in children.

Adolescent↗

PubMedDate not supplied

A local renin-angiotensin system in the human adrenal gland: evaluation of in vitro secretion by a non-parametric combination of randomness permutation tests.

The aim of this study is to assess the mode of release of renin, angiotensin II and aldosterone during in vitro superfusion of the human adrenal gland using a non-parametric combination of four randomness tests. Five normal adrenals and four aldosteronomas superfused over 270 mins were found to concomitantly release renin, angiotensin II and aldosterone. The pattern of this release exhibited a significantly non-random pulsatile character in 17 out of 23 single hormone series (p < 0.05). A further statistical combination-test analyzing the release of each hormone for all experiments with normal and pathological tissue, respectively, showed significant pulsatility (p < 0.01) in 5 out of 6 groups. The pulsatile mode of in vitro hormone release by the human adrenals indicates an active secretory process rather than a discharge of tissue-stored forms. The source of such intra-adrenal intrinsic pulse-generating mechanism could reflect the periodic course of a negative biological feedback reaction.

Adrenal Cortex Neoplasms↗