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F Federici

Publications and source records attributed to F Federici.

51 records · Page 3Linked to original sources
PubMedDate not supplied

Electrokinetic separation of enantiomers using a capillary coated with poly-terguride.

Enantioseparation of 2-arylpropionic acids (Flobufen) and dansyl-derivatives of amino acids can be achieved in 10-15 min by electrochromatography using a capillary coated with poly-terguride. It was found that the analytes, in the range of the buffer pH between 2.5-4.0, were driven by anodic electroosmotic flow originated by the positively charged moieties of the ergolinic skeleton, and, only partially, by their anodic electrophoretic mobility. The enantiomers eluted with the same sequence, e.g. L- or (S)-isomer more retained than D- or (R)-, which was observed in HPLC separations on terguride-silica based CSPs, thus indicating that racemates were resolved by a similar chiral recognition mechanism. The retention of the solutes was affected by the concentration and composition of the effluent. An other mobile phase variable, strongly affecting the selectivity, was the pH of the buffer.

Amino Acids↗
PubMedDate not supplied

[Changes in spirometric values induced by nasally administered beclomethasone dipropionate in patients with perennial allergic rhinitis].

Authors showed that it's possible to control the asthmatic component in patients with persistent allergical rhinitis without bronchodilatory drugs. AA. compared two groups of ten patients: Group A has been treated with antihystaminical drugs or ketotifen per os and Disodium chromoglycate per nasal spray, Group B has been treated with the same drugs and Beclomethasone Dipropionate per nasal spray more (400 mcg a day). Respiratory functionality tests (FEV1 and MEF75) have been carried out at the beginning and at the end of the trial and the subsequent clinical parameters have been considered: dispnoea attacks, rhinorrhaea, sneezes, lost working or school days. The results of the study showed after three months of therapy a statistically significant improvement of FEV1 and MEF75 in Group B only; moreover the patients of the Group B had lower number of asthmatic attacks then patients of the Group A.

Administration, Inhalation↗