Bronchiolitis obliterans with organizing pneumonia: atypical appearance on radiographs.
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Bronchiolitis Obliterans↗
Biomedical subjects
F Fend
Publications and source records attributed to F Fend.
[B-cells in thymic epithelial tumors: phenotype, distribution and relation to the intramedullary B-cell population of the normal thymus].
Immunohistochemical analysis of 26 thymomas and thymic carcinomas revealed the occurrence of two different intratumoral B-cell populations. High numbers of B-lymphocytes with formation of lymphoid follicles were found in the extra-epithelial perivascular spaces of cortical thymomas and well differentiated thymic carcinomas associated with myasthenia gravis. On the other hand, B-cells within the epithelial meshwork frequently occurred in organoid medullary islands of predominantly cortical and cortical thymomas. In their distribution and phenotype, these cells correspond to the intramedullary B-cell population of the normal thymus, reflecting a specific intratumoral B-cell homing dependent on medullary epithelial differentiation.
Antigens, CD↗
Non-Hodgkin's lymphoma of the lung diagnosed by gene rearrangement from bronchoalveolar lavage fluid: a fast and noninvasive method.
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DNA↗
Phenotype and topography of human thymic B cells. An immunohistologic study.
Using single and double labeling immunohistochemical techniques and a large panel of monoclonal antibodies against B-cell differentiation antigens, including those newly defined at the Fourth International Leucocyte Typing Workshop, we have examined the immunophenotype and tissue distribution of human thymic B-cells. The existence of a distinct B-cell population as a constant constituent of the thymic microenvironment has been noted only recently. We found a significant population of B-lymphocytes in the thymic medulla expressing the B-cell restricted antigens CD19, CD20, CD22, CD37, CD72, CD76 and IgM and IgD. As with other extrafollicular B-lymphocytes, they differ significantly from both follicle mantle and germinal center cells in morphology and immunophenotype, which points to alternative modes of B-cell differentiation. Thymic B-cells themselves show considerable heterogeneity and a subpopulation with dendritic features and the expression of CD23 has been referred to as "asteroid" cells. Their close association with T-cells and medullary epithelial cells points to a functional role for B-cells in the thymus. A second population of B-lymphocytes together with frequent lymph follicles is found within the extrathymic perviascular space. Though separated from the medulla by a layer of epithelial cells, a clear distinction between the B-cells of these two compartments is not always possible. The intramedullary B-cell compartment shows a parallel numeric increase with the occurrence of germinal centers in the perivascular space, mostly due to an accumulation of B-cells in the medulla adjacent to these lymph follicles. Thus a close relationship between the intra- and extramedullary B-cell population of the thymus seems likely.
Adolescent↗
[Sudden death of a young asthmatic patient--allergic granulomatous angiitis (Churg-Strauss syndrome)].
Churg-Strauss syndrome has three main criterions: 1) severe asthma with fever attacks, 2) extra- and intravascular granulomatous proliferations of epitheloid and giant cells, 3) inflammatory infiltrates rich in eosinophilic leukocytes. All these features were given in the case of a 19-year-old woman, who died suddenly. This paper deals with the morphological findings of the forensic autopsy.
Adult↗
Cytomegalovirus pneumonitis in heart-lung transplant recipients: histopathology and clinicopathologic considerations.
Three cases of cytomegalovirus (CMV) pneumonitis in heart-lung transplant recipients are presented, and the clinical course and autopsy findings described. The patients survived transplantation for 15, 6, and 2 months, respectively. Cytomegalovirus pneumonitis was diagnosed between 5 and 12 weeks postoperatively, and was still detectable in two of the patients at postmortem examination. In one patient, at autopsy there was no further evidence of CMV pneumonitis 3 months after its onset. Instead we found widespread obliterative bronchiolitis (OB) and signs of acute pulmonary rejection. Early-stage OB was present together with CMV pneumonitis in the patient who had survived transplantation for 2 months. The cause of death in the remaining patient was a bacterial superinfection of the chronic CMV pneumonitis still present more than 1 year after its first manifestation. There were no signs of OB. The marked differences in the clinical course and histologic presentation of CMV pneumonitis in heart-lung transplant recipients and its high, but not uniform, association with OB emphasize the complex interrelations between viral infections and pulmonary rejection.
Adult↗
Cerebral metastasis of endometrial carcinoma.
The case of a woman who died from cerebral metastasis of adenocarcinoma of the uterine corpus, clinical stage IA at the time of first referral, is described. Three months after preoperative endocavitary radiotherapy followed by radical surgery followed by postoperative radiotherapy, the 59-year-old patient developed neurological symptoms. A cerebral tumor was diagnosed and subsequently excised. Histology showed metastasis of an adenocarcinoma. The patient died 3 weeks after cranial surgery. Meticulous postmortem examination failed to reveal any other tumor besides the endometrial neoplasm. Comparative immunohistochemical examination of the primary tumor and the cerebral process supported the assertion that the brain metastasis derived from the adenocarcinoma of the endometrium. Literature reports on cerebral metastasis of endometrial carcinoma are discussed.
Adenocarcinoma↗
Occult papillary carcinoma of the thyroid with pulmonary lymphangitic spread diagnosed by lung biopsy.
Distant metastases from occult papillary carcinoma of the thyroid, which is defined as a tumor less than 15 mm in diameter, are extremely rare. A 21-year-old patient with miliary micronodular densities in both lungs is described, in whom pulmonary lymphangitic spread of occult papillary thyroid carcinoma was diagnosed by transthoracic lung biopsy.
Adult↗
Osteosclerotic myeloma with polyneuropathy and hypocalcemia.
A case is presented of a 46-year-old man with multifocal osteosclerotic bone lesions, peripheral polyneuropathy and hypocalcemia. Histologic examination of a bone marrow biopsy disclosed a multiple myeloma. Immunoelectrophoresis revealed a small M-component identified as IgG-lambda. Osteosclerotic myeloma lacking any osteolytic lesions seems to be very rare and shows several different features as compared with classical myeloma. A review of the current literature suggests that multiple myeloma is not a uniform disease but rather a group of clinical syndromes characterized by the special properties of their proliferating plasma cell clones.
Bone Marrow↗
Diagnostic value of combined bronchoalveolar lavage and transbronchial lung biopsy.
The aim of our study was to assess the diagnostic value of combined transbronchial lung biopsy (TBB) and bronchoalveolar lavage (BAL) in non-immunosuppressed patients, who underwent routine bronchoscopy for evaluation of interstitial lung disease. We examined routinely sampled and processed material from 87 patients from two peripheral pulmological centers and compared the lavage and biopsy results to the final clinical outcome. 22 of these patients showed no evidence of interstitial lung disease during the course of follow-up. Sufficient lung parenchyma was present in 81 of 91 biopsy specimens (including four repeat biopsies), and 79 of 91 BAL samples were considered adequate. The combination of BAL and TBB was more efficient (efficiency 80.3% vs. 67.9% in TBB and 64.6% in BAL) than either method alone. Sensitivity showed a similar increase from 58.8% in TBB and 73.9% in BAL to 79.5% for both combined. Specificity for BAL was a low 60.7% due to contamination by inflammatory cells from upper airways, whereas specificity for TBB was 100%. We conclude that the combination of bronchoalveolar lavage and transbronchial lung biopsy is a valuable tool in the evaluation of interstitial lung disease and should be employed whenever possible.
Adult↗
Cytomegalovirus pneumonitis.
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Cytomegalovirus Infections↗