Direct immunohistochemical detection of binding sites for beta-blocker within rat cerebellum.
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Alprenolol↗
Biomedical subjects
F Ferrante
Publications and source records attributed to F Ferrante.
Cholinergic nerves in the human liver.
The cholinergic innervation of the human liver was studied. Slices (150--200 micrometer thick) of human liver and of the greater hepatic blood vessels (hepatic artery and vein, portal vein) were incubated in a solution of 6-hydroxydopamine (6-HDA) in order to obtain a selective degeneration of adrenergic nerves. Controls were prepared from samples incubated with buffer alone. The slices were cut on a cryostat into 15-20 micrometer thick sections and processed for the histochemical detection of cholinesterases. Cholinergic nerve fibres innervate the extra hepatic and the intrahepatic branches of the hepatic artery, the portal vein as well as the hepatic vein. Fewer cholinergic fibres innervate the hepatocytes and the hepatic sinusoids. The 6-HDA treatment does not seem to alter the pattern of the cholinergic innervation of the liver. The findings indicate the presence of a cholinergic parasympathetic innervation in the human liver.
Acetylcholinesterase↗
Acetylcholinesterase containing nerve fibers in guinea pig ovary.
The distribution of acetylcholine esterase (AChE) in the ovary of normal as well as of sympathectomized guinea pigs was studied. In normal animals AChE-positive nerve fibres were found organized in a perivascular plexus. Some nerve fibres reach the corpus luteum and the follicular wall. Chemical sympathectomy performed with he neurotoxin 6-hydroxydopamine caused an almost complete disappearance of AChE positive nerve fibres suggesting that most of the AChE activity of ovarian nerves is localized in adrenergic nerve fibres. Enzyme activity was also present in smooth muscle cells of the vascular tree.
Acetylcholinesterase↗
Acetylcholinesterase containing nerve fibres in coronary circulation.
The cholinergic innervation of coronary arteries and veins has been studied in the human. Structures resembling cholinergic nerve fibres are localised at the level of the extraparenchymal branches of the coronary arteries, organised in the adventitial plexus. Neither the coronary veins nor the intraparenchymal blood vessels are provided with a cholinergic innervation. Those findings are discussed.
Acetylcholinesterase↗
Influence of hypothyroidism on histochemical pattern of peripheral nerves.
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Animals↗
[Congestive cardiomyopathy of probable viral origin in a 24-year-old man].
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Adult↗
Acetylcholinesterase-containing nerve fibers in the dura mater of guinea pig, mouse, and rat.
The cholinergic innervation of the dura mater in the guinea pig, mouse and rat has been investigated. The dura mater is provided with a cholinergic innervation. After short incubation times (4--6 hours) we found acetylcholinesterase (AChE)-containing nerve fibers in close relationship with the main meningeal blood vessels. After longer incubation times, AChE-containing nerve fibers appear also in the meningeal tissue proper. Chemical sympathectomy, performed with the neurotoxin 6-hydroxy-dopamine, does not seem to interfere with the pattern of the dural cholinergic innervation. The findings are discussed.
Acetylcholinesterase↗
Cholinergic nerves in dog cerebral vessels.
The presence of a cholinergic innervation of the main cerebral blood vessels has been studied in the dog. Cholinergic nerve fibers are found in all examined arteries and veins, organized in two or in a single nerve plexus. The cerebral veins appear to be less innervated than arteries. The meaning of a cholinergic innervation in the cerebral circulation is discussed.
Animals↗
The cholinergic innervation of the aorta.
The cholinergic innervation of the aorta has been studied in some mammalian species. Cholinergic nerve fibers (CNF) are organized in the aorta of the rabbit, kid, lamb, and guinea pig in 2 plexuses. The plexuses of CNF consist of a superficial plexus localized in the adventitial layer and a deep one localized in the adventitial-medial transitional zone. Some CNF reach the outer layers of the media. In the aorta of the dog, mouse and rat CNF are organized in a single plexus localized in the adventitial layer. This nerve plexus is formed of CNF that for the most part are distributed to the vasa vasorum. The chemical sympathectomy don't alters the pattern of the cholinergic innervation of the aorta, indicating that stained CNF are parasympathetic in nature. The meaning of a cholinergic innervation of the aortic wall is discussed.
Animals↗
Histochemical studies on the autonomic innervation of the femoral artery and vein.
The innervation of the femoral artery and vein in the dog was studied using: a) glyoxylic acid fluorescence (for the histochemical localization of adrenergic nerve fibers); b) acetylcholinesterase (for the histochemical localization of cholinergic nerve fibers). -Andrenergic nerve fibers and related terminals in both vessels are confined to the adventitial-medial transitional zone and the outer layers of the media. Acetylcholinesterase containing nerve fibers are localized in the adventitial-medial transitional zone of the femoral artery. These findings may indicate the presence of a cholinergic vasodilatator system in the control of the circulation in the femoral artery.
Acetylcholinesterase↗
Cholinergic nerves in blood vessels of the female reproductive system.
Cholinergic innervation of the blood vessels of the female reproductive system was investigated in human by the cholinesterase method. The following results were obtained: 1. The uterine and vaginal arteries are provided with a rich cholinergic innervation. 2. The ovarian, tubaric and ovarian-uterine artery are poorly innervated. 3. The ovarian and uterine vein are not provided with a cholinergic innervation.
Acetylcholinesterase↗
Pupillary attributions of college students to happy and angry faces.
As evidence for an hypothesis that pupil size plays an important role in nonverbal communication, Hess (1975) has reported that adults draw in appropriately sized pupils on his happy and angry faces task. However, he did not report a statistical test of his data. In this study, we replicated Hess' research and found congruent with his hypothesis that college students (n = 223) draw in significantly larger pupils on the happy face.
Cues↗
Pain thresholds in rats during recovery from REM sleep deprivation.
Using 30 Sprague-Dawley female rats, threshold to pain was measured over the course of recovery from REM sleep deprivation. Relative to the untreated controls and to their own pretreatment thresholds, the REM-deprived animals showed significantly reduced pain thresholds which were still evident 96 hours after the termination of the REM deprivation. Possible implications of these data for research with analgesic drugs were noted.
Animals↗
Cholinergic nerves in the thyroid gland.
The cholinergic innervation of the thyroid gland has been studied in the human. AChE positive nerve fibers are localized in the wall of the thyroid artery, arranged in two plexuses, a superficial (adventitial) and a deep one (medial). The glandular tissue is provided with cholinergic nerve fibers, localized between and around thyroid follicles. The present results suggest that the endocrine activity of the thyroid gland is also under the control of the autonomic nervous system.
Acetylcholinesterase↗
Double-blind clinical comparison between a gastrin-receptor antagonist, proglumide, and a histamine H2-blocker, cimetidine.
A double-blind trial was carried out in 30 patients with peptic ulcers to assess the effects of treatment with a gastrin-receptor antagonist, proglumide, compared with a histamine H2-blocker, cimetidine. Patients received either 1200 mg proglumide or 1200 mg cimetidine per day for 28 days. The results showed that both drugs significantly reduced clinical symptoms and gastric secretion. In patients treated with cimetidine there was a significant increase in blood gastrin levels and marked hypertrophy and hyperplasia of the antral mucosa was observed in almost all patients. No such changes were found in the patients treated with proglumide.
Adult↗
Reduced lipofuscin accumulation in senescent rat brain by long-term acetyl-L-carnitine treatment.
By using fluorescence microscopy and microfluorimetric techniques, the effects of ageing and of 11 months acetyl-L-carnitine (ALCAR) treatment on lipofuscin deposition within the cytoplasm of pyramidal neurons of rat prefrontal cortex and hippocampus (CA3 field) were assessed. No lipofuscin autofluorescence was observed in the nerve cell bodies of neurons under study in young rats (3 months of age), but lipopigment had accumulated in the same nerve cells of senescent rats (22 months of age). ALCAR administration significantly reduced the accumulation of lipofuscin within pyramidal neurons of the brain areas examined.
Acetylcarnitine↗
Age-dependent nerve cell loss in the brain of Sprague-Dawley rats: effect of long term acetyl-L-carnitine treatment.
The age dependent loss of nerve cells was investigated in 22 brain areas from young (3 month), adult (13 month) and old (25 month) Sprague-Dawley rats. As in previous studies, we observed an age-related neuronal loss primarily in the archicortex and in the hippocampus and in other subcortical structures (amigdaloid nucleus, pontine nuclei, cerebellar cortex). In sensory areas of cerebral cortex the neuronal loss was less marked. The effect of a 6 month treatment with acetyl-L-carnitine (ALCAR) on the number of nerve cells in the same brain areas was also investigated. ALCAR treatment began when the rats were aged 16 months. ALCAR treatment was able to counteract the age-dependent decrease in nerve cell number primarily in the temporal and occipital cortical areas, in the archicortex and hippocampus. The above findings suggest that long term ALCAR treatment may be effective in slowing down the age-related nerve cell loss in some rat brain areas.
Journal Article↗
Lactate dehydrogenase, succinate dehydrogenase and nucleotide tetrazolium reductase histochemical activities in the mesentric arteries and arterioles of young and old rats.
Age-related changes of the metabolic characteristics of large, medium and small brances of the rat superior mesenteric artery were investigated in young (4 month) and old (25 month) male Wistar rats, using enzyme histochemical techniques. The following enzymatic activities were examined: lactate dehydrogenase (LDH) and succinate dehydrogenase (SDH); NADPH(2)-tetrazolium reductase (NADPHD) and NADH(2)-tetrazolium reductase (NADHD). The intensity of enzymatic reactions within the tunica media of the large, medium and small branches and within the tunica intima of the large and medium branches of the artery was assessed microphotometrically. In young rats the reactivity of enzymes investigated is similar in both the tunica media and the intima with the exception of SDH which reacts stronger in the media than in the intima. LDH and NADHD displayed the most intense reaction whereas SDH reaction was less intense. In old rats LDH and NADPHD reactivity decreased, SDH reactivity increased in the intima of large and medium branches; and SDH increased in the media of large branches. The possibility is discussed that an impaired endothelial function may represent one of the most consistent phenomena of aging of the superior mesenteric artery.
Journal Article↗