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Biomedical subjects

F Ferrara

Publications and source records attributed to F Ferrara.

At least 37 records · Page 2Linked to original sources
PubMed1987

Effects of lincomycin on the immune system.

The effects of lincomycin on the immune system were studied on patients suffering from chronic bronchitis by means of phagocytosis, chemotaxis and natural-killer tests. The tests were performed before and 2, 4, 8, 12 and 24 h after administration of 600 mg lincomycin i.m. in a single dose. The results indicate that lincomycin stimulates phagocytosis, expressed as enhanced superoxide production (O2-), chemotaxis and the activity of natural killer cells, measured on the basis of their ability to perform a lysis on the K562 tumoral target labelled with 51Cr. The stimulating effects on chemotaxis appear already 2 h after the administration of the drug, while the same effect on phagocytosis and natural-killer activity occurs after 4 h. The maximal stimulating activity on all three parameters can be shown at 8 h and disappears at 24 h.

Adult↗
PubMed1986

Evaluation of the immunostimulating activity of erythromycin in man.

The effects of erythromycin on the immune system have been studied in healthy volunteers and patients suffering from chronic bronchopneumonial diseases, by means of the following assays: phagocytosis, natural killer activity and superoxide anion production. The tests were performed before and after oral administration of 1 g of erythromycin. The findings suggest that erythromycin enhances phagocytosis by means of increasing ingestion of microorganisms, superoxide anion (O2-) production as well as natural killer activity. Under the experimental conditions described these effects appear 4-6 h after drug intake and reach their maximum around the 8th hour.

Adult↗
PubMed1986

Differentiated distribution of norfloxacin in the medullary-cortical part of the kidney in man.

Norfloxacin administered orally in a single dose of 400 mg, rapidly reaches high levels in the renal tissues, and provides an effective therapeutic action against sensitive pathogen germs. Twelve hours after administration, the drug is still detectable in the renal tissue; particularly, it was evidenced a positive tropism in the medullary part of renal parenchyma, where they were found norfloxacin levels far higher than those of cortical parts.

Female↗
PubMed1985

Position of ceftazidime in respiratory diseases.

Twenty patients (10 males and 10 females), ranging in age from 53 to 81 years, were treated with ceftazidime, 2-3 g/day i.m., for 12 to 15 days. All patients were suffering from moderate to severe infections of the lower respiratory tract (6 cases of pneumonia and 14 cases of acute exacerbation of chronic bronchitis). In addition, almost all patients presented severe local and general predisposing factors (three patients with lung cancer, two with bronchiectasis and 14 with respiratory insufficiency). The aetiological agents responsible for the infections were mainly Gram-negative bacteria (6 Klebsiella pneumoniae, 4 Haemophilus influenzae, 4 Pseudomonas aeruginosa and 3 Proteus strains). The clinical and microbiological results of the treatment were good. With the exception of one case of maculopapular rash, none of the patients complained of adverse reactions and no toxic effects were observed.

Aged↗
PubMed1985

Physiopathological rationale and clinical aims of the use of a combination of cefuroxime and N-acetylcysteine in pneumology.

The trial population consisted of 50 patients suffering from acute exacerbations of chronic bronchial disease processes. Forty patients were treated with an extempore combination of cefuroxime and N-acetylcysteine at the doses of 2 g and 600 mg/day respectively in two i.m. administrations. The other 10 patients were treated with N-acetylcysteine alone at the same dose. Respiratory tract clinical and instrumental parameters were investigated, and bacteriological tests were performed on sputum samples before and after treatment. Tolerance of the treatment was assessed on the basis of measurement of blood-chemistry parameters.

Acetylcysteine↗
PubMed1978

[Biliary peritonitis. Clinical and statistical findings in 37 cases].

Following an aetiopathogenetic and physiopathological discussion of biliary peritonitis, a statistical analysis of the main clinical symptoms observed is presented on the basis of 37 personal cases with a view to highlighting diagnostic factors capable of identifying a disease process which may easily be confused with other acute abdominal diseases. The need to intervene as quickly as possible is finally noted.

Adult↗
PubMed1977

[Proximal selective vagotomy. Statistical review approximately 200 cases of selective vagotomy. Preventive note].

Gastric resection for the correction of duodenal hyperacidity in patients suffering from duodenal ulcer has always seemed out of proportion to the objective which is simply that of the clinical and anatomopathological cure of a small lesion. Vagotomy, particularly proximal selective v. offers the surgeon a rational approach to duodenal ulcer. This is also seen in the series of the F. Ponti Surgery Division of the Ca' Granda General Hospital of Milan.

Duodenal Ulcer↗
PubMed1977

[Suppurative disease of the ano-rectal tract].

Suppuration of the anal-rectal tract usually requires nothing more than ordinary surgical management. In many cases, however, particularly when the fistula lies entirely above the anal sphincter, the picture is complicated, with recurrences and exacerbations. In addition, incontinence following unsuitable surgery may constitute a possible risk. Statistical assessment of a personal series is primarily directed to analysis of factors leading to chronic evolution of the disease and its complications. Eclectic management founded on the surgeon's experience, but nevertheless based on well-defined techniques, will be found to offer the best results.

Adolescent↗