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Biomedical subjects

F Ferrari

Publications and source records attributed to F Ferrari.

At least 199 records · Page 11Linked to original sources
PubMed1984

Metabolic and nutritional factors in the pathogenesis of idiopathic osteonecrosis of the head of the femur (preliminary results of a long-term follow-up investigation).

A double statistical study of a group of 56 patients affected by idiopathic osteonecrosis of the head of the femur is presented. A comparative investigation was undertaken into this group, taking into consideration the principal biochemical parameters, clinical findings, dietary and living habits. The statistical data that were analysed confirmed the role of some of the aetiological factors concerned. A long-term study was also undertaken, with a preliminary follow-up at 22 months, on the progress of the patients with monolateral idiopathic osteonecrosis of the femoral head who were subjected to a therapeutic programme of dietary correction and the administration of medicaments.

Adult↗
PubMed1983

The role of dopaminergic receptors in the behavioral effects induced by lisuride in male rats.

Lisuride increased the incidence of stretching and yawning (SY) as well as of penile erection (PE) and elicited stereotyped behavior (SB), aggressive behavior and mounting in male rats, depending on the dose used. SY was prevented by two dopaminergic antagonists, haloperidol and sulpiride, but not by methysergide, a serotoninergic antagonist, while PE was antagonized by all three drugs. With regard to SB, aggressive behavior and mounting, all three were suppressed by haloperidol; sulpiride, while partially antagonizing aggressiveness, failed to affect SB and mounting; methysergide did not significantly influence any of the three. This suggests that lisuride principally affects the dopaminergic system. Although further detailed studies are required to elucidate which type of the complex population of DA-receptors is involved in each kind of behavior, we suggest that SY at least is due to the activation by lisuride of presynaptic DA-receptors.

Aggression↗
PubMed1983

Neurobehavioural comparison of low-risk preterm and fullterm infants at term conceptional age.

The neurobehavioural performances of 20 low-risk preterm infants born at 33 weeks gestation or less were examined with the Brazelton Scale at the expected date of delivery, and 20 healthy fullterm infants were also examined on the fifth day of life. The preterm infants were significantly inferior in orientation, motor performance, regulation of state and autonomic regulation. With the exception of autonomic regulation, the neurobehavioural clusters were more heterogeneous among the preterm group. The data suggest that low gestational age at birth, even following relatively normal pre-, peri- and neonatal development, is associated with a behavioural repertoire which is different, more heterogeneous and on average poorer than that of fullterm infants.

Child Behavior↗
PubMed1982

Potentiation of the aphrodisiac effect of N-n-propyl-norapomorphine by naloxone.

N-n-Propyl-norapomorphine (NPA), a potent dopamine (DA) receptor stimulant, in doses from 0.4 to 80 micrograms/kg i.p. produced a dose-related sexual stimulant effect characterized by recurrent episodes of penile erection (PE). The number of episodes and percentage of responding subjects were proportional to the dose. However, above the maximal effective dose, the effect decreased in a dose-related fashion until beyond 2.5 mg/kg even the natural occurrence of PE was suppressed. Morphine (5 mg/kg), as well as haloperidol (0.3 mg/kg), prevented NPA stimulation. Naloxone, which per se caused a modest increase in PE, markedly potentiated the stimulant effect of low doses of NPA, reversing the inhibitory component of higher doses. We suggest that NPA stimulation of DNA receptors causes release of opiate peptides, dampening the sexual stimulant response. The combination of DA receptor stimulants with naloxone might offer a new possibility for erection defect therapy.

Adrenocorticotropic Hormone↗
PubMed1982

Ultrasonographic patterns in hepatic hemangiomas.

Twenty-one cases of hepatic hemangioma were examined by ultrasound, and three main sonographic patterns were identified. In 14 cases hyperechoic focal areas were observed, in five cases larger hemangiomas exhibited a complex pattern, and in two cases hemangiomas appeared as rounded sonolucent areas with distal enhancement mimicking cysts. Hemangiomas may have significantly variable ultrasonographic features. According to the authors' experience, only in cases of hyperechoic well-defined lesions in asymptomatic patients can a definite diagnosis of hemangioma be made.

Adult↗
PubMed1982

Influence of lisuride on morphine withdrawal signs in the rat: a dopamine-mimetic effect.

The influence of lisuride on naloxone-induced withdrawal signs (wet shakes, escape attempts) was studied in morphine-dependent rats. Lisuride, injected IP at doses of 12.5 and 25 micrograms/kg, inhibited wet shakes while not significantly altering escape attempts induced by naloxone (4 mg/kg IP). At higher doses (50 and 100 micrograms/kg IP), lisuride's inhibitory effect on wet shakes persisted while escape attempts were actually potentiated with respect to control withdrawal rats. Increases in aggressive behavior were seen at all doses, and were dose-related. Haloperidol (0.3 mg/kg IP), administered 40 min before lisuride, did not modify the antagonistic effect on wet shakes, unlike sulpiride (40 mg/kg IP 30 min before lisuride), but at the same time blocked the increase in escape attempts and aggressiveness induced by lisuride. We suggest that lisuride modulates withdrawal signs by stimulation of dopamine receptors in the CNS. The effect of the dopamine mimetic N-n-propylnorapomorphine (NPA) on the same variables is reported as well as the influence of haloperidol on NPA, and a comparison between the effects of the two drugs is made.

Aggression↗
PubMed1982

Pancreatic cystadenocarcinoma: diagnostic problems.

Eleven cases of pancreatic cystadenocarcinoma were studied with respect to the differential diagnosis from that of pancreatic pseudocysts, using diagnostic ultrasound as the initial investigative technique. Most of the cases presented an ultrasonic picture that correlated well with the gross pathology, but this correlation was not reliable enough to be considered characteristic in differentiating such masses from pseudocysts. The authors divide the cystadenocarcinomas of the pancreas into four echographic classes. In all but one of the classes, diagnostic ultrasound was insufficient by itself to render an accurate diagnosis. In such cases other techniques, i.e. CT, tissue biopsy, and especially angiography, were required for a reliable diagnosis.

Adult↗
PubMed1981

Vision in the neonate (full-term and premature): preliminary result of the application of some testing methods.

Little information is available on the functionality of the visual system in neonates. Comparison was made between neonates born at full term and prematures equated for conceptional age, using two methods of investigation: the visual evoked potential (VEP) and the "forced preferential looking" (FPL). The results obtained by the FPL method indicate a greater visual acuity in premature subjects, whereas the results obtained by the VEP method point to no significant difference in implicit time between the two groups.

Evoked Potentials↗
PubMed1981

[Splenic artery aneurysm. Review of literature and report of 2 clinical cases].

Two cases of successful surgical management of aneurysm of the splenic artery are presented. One aneurysm was of considerable size, while the other was accompanied by haemoperitoneum, owing to spontaneous intrasplenic rupture. The literature is reviewed and the data still quoted in recent publications are updated. Modern views on the origin of this condition, formerly regarded as primarily due to arteriosclerosis, are illustrated. Stress is laid on the part played by repeated pregnancy in the progressive irreversibility of damage to the elastic fibers of the arterial walls. Lastly, an account is given of the clinical and diagnostic aspects of these aneurysms. Surgical management is stated as a personal preference, since the serious general condition of the patient means that it is rarely contraindicated.

Aged↗