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Biomedical subjects

F Ferraris

Publications and source records attributed to F Ferraris.

11 recordsLinked to original sources

[The role of aromatase inhibitors in the treatment of breast neoplasms. An evaluation of clinical efficacy and the tolerability profile].

Constant acquisitions regarding endocrine pathogenesis and the biology of breast neoplasms have led to the evolution of hormone manipulation as a therapeutic option in patients suffering from this disease. There has been a shift from ablative surgical procedures to the use of drugs offering greater clinical efficacy and an improved tolerability profile. Since the late 1970s tamoxifen has been regarded as the gold standard for hormone treatment in hormone-responsive breast neoplasm, but promising new endocrine agents are now being compared in random trials. Of these, the latest generation of aromatase inhibitors appears to gather the widest consensus on the basis of the results published to date. This article aims to review this new category of drugs, illustrating their rationale of use, the results obtained in the treatment of breast neoplasm and the main studies in which they are currently being investigated.

Adult↗

[Epidemics of lung tumors in a Biella tannery].

A cluster of 7 lung cancer deaths among workers of a small tannery in Biella is reported. The major process in the plant, until the end of World War II, was chromium and vegetable tanning. A historical cohort study was carried out on a total of 353 male workers. The expected number of death was estimated on the basis of local mortality rates. An SMR for lung cancer of 449 (95% C.L. 180-925) was found for the entire cohort. Excluding workers non specifically employed in tanning operations, the SMR for lung cancer increased to 1087 (95% C.L. 352-2533). In order to control for potential confounders a nested case-control study was planned. The next-of-kin of 8 cases deceased for lung cancer and 32 controls matched by age were interviewed on smoking habits and previous jobs. Logistic regression analysis showed an O.R. of 6.94 (95% C.L. 1.18-40.73), adjusted for smoking habits and occupational history, for subjects involved in tanning operations. A registry of incident cases of cancer was established in order to avoid biased findings based on cluster cases.

Adult↗

A descriptive method for automatically analysing uterine forces during labor.

In recent years many authors have considered evaluation of uterine contractility by means of analysis of amniotic fluid pressure variations. The reason for this is the introduction in obstetrical management of equipment for the recording of amniotic fluid pressure variations which is a powerful facility for clinical investigation, particularly, if it is considered that previous research has been based upon clinical evaluations and measurements carried out by extra and intra-uterine manometers. Important results of these studies are the definitions of two labor indices, the Montevideo unit (defined as the sum of the maxima of the pressure signal of all uterine contractions during a time interval of ten minutes) and the Alexandria unit (which also takes into account the duration of the contraction:this unit corresponds to the Montevideo unit multiplied by the mean value of the duration of the considered contractions). It is very difficult, however, in fact almost impossible, to summarize the evaluation of labor as the only indes. Many parameters which characterize the shape, frequency and tone of contraction patterns, may be themselves important and could indicated the presence of pathological elements. At present it is not well known which parameters are useful. Since many different sets of parameters can be chosen to characterize the signal, the first point is to determine which is more important clinically. The aim of this paper is to study a procedure of intrauterine pressure signal analysis, which allows the description of uterine contraction by a set of parameters that is interesting for research purposes during labor and suitable for continuous monitoring. The set of parameters was chosen in order to repeat quantitatively the qualitative analysis which a physician can make by a simple inspection of the pressure signal oscillogram. Visual examination of the tocograph results is a clumsy means for evaluating labor performed by an experienced physician. It may appear that the pressure starts "suddenly" (or not) to increase and rises "quickly" (or "slowly"), then it maintains "high" (or "low") mean values for a "long" (or "short") time, with "smooth" (or "irregular") behaviour, then it decreases "quickly" (or slowly, until "suddenly" (or "smoothly") it reaches its basal level, whd the beginning of another uterine contraction is "long" (or "short", during this time the pressure is "almost" constant (or has a "drift" and/or presents "many irregularities"). Therefore the 25 chosen parameters replace quantitatively the above qualitative evaluations. These parameters are not put forward to indicate directly the presence of pathological facttor, but summarize all the interesting clinical aspects of the contraction waveform for research and monitoring purposes. The parameters are extracted using a pattern recognition algorithm based on a structural representation of the contraction (Tables I, II, V)...

Computers↗

A case-control study of carcinomas of the nose and paranasal sinuses in the woolen textile manufacturing industry.

A population-based case-control study was conducted in Biella, which is located in northwestern Italy, to investigate the reported association between sinonasal carcinomas and woolen fabrics production. The study included 33 cases diagnosed during 1976-1988 (14 adenocarcinomas, 11 epidermoid carcinomas, 3 other specified carcinomas, 1 unspecified carcinoma, and 4 cases without histologic confirmation) and 131 controls. No association was found with smoking. As reported previously, excess risks were observed in wood and furniture workers (odds ratio [OR] = 4.4, 95% confidence interval [95% CI] = 1.41-13.4) and in the leather industry (OR = 3.5, 95% CI = 0.6-20.3). Odds ratios in the wood and furniture industry were 22.0 (95% CI = 4.4-124.0) for adenocarcinomas and 0.9 (95% CI = 0.4-8.3) for epidermoid carcinomas. No association was found with the woolen textile or garment industries (OR = 0.8, 95% CI = 0.2-2.8), nor with farming, construction, metal works, and transport. Odds ratios for the textile industry did not vary with length of exposure or histologic type. Power for detecting an odds ratio of 3.0 at the 95% level of significance was 40%.

Aged↗