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Biomedical subjects

F Ferrozzi

Publications and source records attributed to F Ferrozzi.

12 recordsLinked to original sources

[Hemosiderosis in thalassemia major. Quantitative study with magnetic resonance (MR)].

Hemosiderosis, which results from transfusional therapy and from increased absorption of dietary iron, is a severe complication of thalassemia major. The complication is also very difficult to manage. An accurate determination of the total amount and of the distribution of body iron stores is essential for prognostic purposes and to evaluate the efficacy of chelation therapy. Therefore, a suitable tool for the noninvasive depiction of iron overload is to be hoped for. MR imaging has been usefully employed, of late, to this purpose. Sixteen thalassemic patients have been studied to evaluate iron depositions using a 1.5 T magnet. Signal intensities from liver, pancreas, spleen, bone marrow, and heart were considered. The signals were dramatically lower than the normal values obtained in a sex- and age-matched group; the differences were due to the iron. Iron distribution appeared inhomogeneous, with the highest overload in liver and bone marrow. Since cardiomyopathy represents the first cause of death in thalassemic patients, the relationship between cardiac function and iron overload in the heart has been thoroughly investigated. Finally, the authors conclude that MR will become a widely employed method for assessing iron overload and will contribute to improve the management of thalassemia major.

Adolescent

[X-ray computed tomographic aspects of calcifying metastases. Apropos of 40 cases].

The authors report the results of a study on 40 patients affected by metastases of the calcifying type detected during CT scan imaging for cancer of different origin (colorectum 18 cases, stomach 5, ovary 10, lung 2, bone 2, breast, skin, thyroid 1 case). The sites involved include liver (22), spleen (5), lymph nodes (10), peritoneum (7), diaphragm (2), pleura (2), ovary (1), soft tissue (3), lung (3). Calcification in metastases arises through a double mechanism: primary, with bone formation in osteoid neoplasia (orthoplastic calcification) or ossification of tumour cartilage (metaplastic calcification); secondary as a result of necrosis, hemorrhage and regressive changes (dystrophic and mucoid calcification), particularly after radiation or systemic treatment. Since calcified metastases can strongly mimic granulomatous, parasitic and other neoplastic disease, the clinical history is essential for the diagnosis.

Calcinosis

[Pancreatic cystic neoplasms. Echographic-CT aspects and differential diagnosis].

Cystic neoplasms of the pancreas are rare lesions. Following the Compagno-Oertel classification, we differentiated serous microcystic adenomas (SMA) from mucinous macrocystic adenomas/adenocarcinomas (MMA). The former are benign tumors with slow growth, composed by innumerable small and tiny cysts with central calcifications, resulting in a "honeycomb" pattern. They have a mixed US structure while CT densitometric values reflect a mixture of connective tissue and proteinaceous fluid. Postcontrast enhancement is frequently seen. MMA are potential (adenoma) or frankly (adenocarcinoma) malignant tumors. They appear as multilocular cystic masses containing septa and/or papillary bulges, with thickened walls. Both US and CT demonstrate their predominantly cystic character, and the eventual presence of excrescences. We report a series of 23 cases (6 SMA, 17 MMA) of cystic neoplasms of the pancreas studied during the past five years. A correct diagnosis of SMA was possible in all 6 cases, while MMA was correctly diagnosed in 17 out of 18 cases. There were no false negatives, and 1 false positive. All differential diagnoses are also discussed.

Adenocarcinoma, Mucinous

[Milk of calcium renal lithiasis: uro-echographic evaluation].

From the fortuitous observation of a rare case of "milk of calcium" lithiasis in a renal calyceal diverticulum, the authors, having examined the etiopathogenetic implications of the disease and having considered the problems of differential diagnosis, discuss whether urography and sonography are a valid means of making a correct diagnosis and the consequent implications of a therapeutic nature which this pathology would involve.

Aged

[CT in the evaluation of the extension of bronchogenic carcinoma].

The computed tomographic patterns in 52 patients with histologically proven lung cancer are reported. The AA. underline the not sobstitutive role of C.T. scan in pre-operative determination of bronchogenic carcinoma extension. C.T. revealed a very high diagnostic accuracy in assessing the primary tumor extension and in evaluating distant macrometastases; however, in showing hilar and mediastinal nodal involvement has not the same accuracy. The AA. think that, at the present time, a combinate C.T. study of the chest, upper abdomen and brain is, in the most number of cases, a rapid, accurate and practical method to evaluate the extension of lung cancer.

Adrenal Gland Neoplasms

[Echotomography-computerized tomography integration in the tissue characterization of renal angiomyolipoma].

A sonographic and a computed tomographic study of 29 patients was performed in order to assess the possibilities of these imaging techniques in tissue characterization of renal angiomyolipoma. From the review of the results the authors, confirming the very high accuracy of the two associated methods for a correct diagnosis, underline the possibility to identify the hamartoma mesenchymal components with the possibility of more prognostic and therapeutic informations.

Female