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Biomedical subjects

F Fey

Publications and source records attributed to F Fey.

At least 37 records · Page 2Linked to original sources
PubMed1976

[A modified screening model for potential cancerostatics by i.v. application of L 1210 ascites cells (author's transl)].

Intravenous application of L 1210 ascites cells failed to produce generalized leukemias. The treated animals died after 6-7 days within a short interval time, revealing the picture of massive tumor cell infiltrations in liver and spleen. Using histological and autoradiographical methods it has been established that the primary processes of ascites cell proliferations occur in liver and spleen. The tested reference substances, cytosine arabinoside and cyclophosphamide, showed in this modified model the same effects as after intraperitoneal application. The extremely short death interval of the control animals makes possible a more precise distinction between the death curves of control and test groups.

Animals↗
PubMed1975

[A transplantable myeloid hamster leukemia with high peripheral leukocyte counts and C-particles. I. Transplantation experiments, pathogenesis, and electron-microscopic observations (author's transl)].

In this article is reported a generalized leukemia of the myeloproliferative system of golden hamsters capable of cellular transmission. Cellfree transmissions to 83 golden hamsters after a 6-month latency period, have so far yielded the same result in three cases. After cellular transplantation leukocyte counts of 180,000 on the average occured abruptly in the end-phase of the disease. Latencies were between 4 and 10 days. Electronmicroscopically, oncorna-viruses were demonstrated in hamsters inoculated with either the cellular or the cellfree preparation that bear close resemblance to the murine C-particles.

Animals↗
PubMed1975

[A transplantable myeloid hamster leukemia with high peripheral leukocyte counts and C-particles. II. Histology and cytochemistry (author's transl)].

Results on morphologic and hematologic characterization of a hamster leukemia capable of both cellular and cellfree transmission are described. Solid tumors removed in the course of several passages of leukemia animals, after producing blood smears, and spleen, liver, lymph nodes, bone marrow, thymus, kidney and lung were investigated histologically and histochemically. The morphological picture of the hamster leukemia has not changed during several transplantation generations. In addition to solid tumours, typical leukemic infiltration were detected histologically in spleen, liver, lymph nodes, bone marrow, kidneys and lung. No leukemic proliferation was noticed in the thymus. The final stage of the disease is characterized by an abrupt occurrence of high leukemic cell counts. The demonstration of alkaline phosphatase, but especially of naphtol-AS-D-chloroacetate esterase, in the leukemic cells is interpreted as indicating malignization of cells of the granulocytic line.

Alkaline Phosphatase↗
PubMed1975

[Presence of RNA-and DNA-tumor viruses within a cell line from mouse spleen and thymus (author's transl)].

Cells of spleen and thymus from mice infected with Rauscher leukaemia virus were cultivated in vitro. A new cell type repeatedly grew out of this cell line. Electron-optically, RNA--viruses and DNA-viruses were found within the new lines, but there was no cell containing both viruses at the same time. According to experimental results in rats, the DNA virus is polyoma-like. The importance the presence of two different viruses within the same cell is discussed.

Animals↗
PubMed1975

[Ultracytochemical studies on leukemic cells].

The present survey of ultracytochemical investigations in the cells of the Graffi and Rauscher leukaemic systems is intended to throw a light on the place of replication and on the incorporation of cell specific material into the virus. The successful evidence of incorporating certain enzymes associated to the membrane into the virus envelope could have a significance in so far as this process can be used to explain the appearance of cytotropism in certain kinds of virus to a target cell.

Acid Phosphatase↗