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Biomedical subjects

F Fidler

Publications and source records attributed to F Fidler.

13 recordsLinked to original sources
PubMed2004

Imaging lung function using rapid dynamic acquisition of T1-maps during oxygen enhancement.

This paper describes imaging of lung function with oxygen-enhanced MRI using dynamically acquired T1 parameter maps, which allows an accurate, quantitative assessment of time constants of T1-enhancement and therefore lung function. Eight healthy volunteers were examined on a 1.5-T whole-body scanner. Lung T1-maps based on an IR Snapshot FLASH technique (TE = 1.4 ms, TR = 3.5 ms, FA = 7 (composite function )) were dynamically acquired from each subject. Without waiting for full relaxation between subsequent acquisition of T1-maps, one T1-map was acquired every 6.7 s. For comparison, all subjects underwent a standard pulmonary function test (PFT). Oxygen wash-in and wash-out time course curves of T1 relaxation rate (R1)-enhancement were obtained and time constants of oxygen wash-in (w(in)) and wash-out (w(out)) were calculated. Averaged over the whole right lung, the mean w(out) was 43.90 +/- 10.47 s and the mean (w(in)) was 51.20 +/- 15.53 s, thus about 17% higher in magnitude. Wash-in time constants correlated strongly with forced expired volume in one second in percentage of the vital capacity (FEV1 % VC) and with maximum expiratory flow at 25% vital capacity (MEF25), whereas wash-out time constants showed only weak correlation. Using oxygen-enhanced rapid dynamic acquisition of T1-maps, time course curves of R1-enhancement can be obtained. With w(in) and w(out) two new parameters for assessing lung function are available. Therefore, the proposed method has the potential to provide regional information of pulmonary function in various lung diseases.

Administration, Inhalation↗
PubMed2000

[Biliary tract injury in laparoscopic cholecystectomy--case report].

The author presents a case of injury of the efferent biliary pathways after laparoscopic cholecystectomy in a 81-year-old female patient. Reconstruction of the injury is always an important procedure for the patient not only with regard to immediate postoperative complications but also for his future life. Referring the patient to a superior department is indicated but often impossible. The author summarize briefly the principles of treatment. After revision which was more than 5 weeks after the primary operation the patient survived the reconstruction and is now, after 18 months, in good health.

Aged↗
PubMed1994

[Evaluation of laparoscopic and laparotomy cholecystectomy by comparing the dynamics of acute phase proteins].

The authors investigated in two groups of surgical patients subjected to laparoscopic (n = 10) and laparotomic (n = 10) cholecystectomy changes in the levels of nine acute stage proteins. The objective was to evaluate the extent of surgical stress of the two surgical procedures with regard to changes of serum levels of albumin, transfirrin, prealbumin, alpha 1-antitrypsin, alpha 1-acid glycoprotein, alpha 2-macroglobulin, haptoglobin, ceruloplasmin and C-reactive protein. Before operation no significant differences (p < 0.05) were found between the investigated indicators. Changes of acute stage proteins up to the third day following surgery indicate a lower surgical trauma and more favourable course during the early postoperative period in patients operated by the laparoscopic route.

Acute-Phase Proteins↗
PubMed1991

[Dieulafoy's disease--an uncommon cause of severe gastrointestinal hemorrhage].

Morbus Dieulafoy described in the European literature as exulceratio simplex, in the English and American literature as a gastric aneurysm or submucosal arterial malformation is a life endangering haemorrhage which, if treated conservatively, leads to death by exsanguination. It is haemorrhage from an aroded medium-sized or major artery with a possible mucosal defect with a minimal or no inflammatory reaction. The localization on the anterior or posterior wall of the fundus or body of the stomach is typical. There are, however, also cases of haemorrhage from a submucosal artery in other parts of the GIT--pylorus or even jejunum (3, 5). In the presented case-history the authors describe an atypically located source of haemorrhage in a parapapillary position on the descendent part of the duodenum.

Aged↗
PubMedDate not supplied

Memory deficits associated with chronic fatigue immune dysfunction syndrome.

Performance on tests of memory in 39 patients who met Center for Disease Control (CDC) criteria for chronic fatigue immune dysfunction syndrome (CFIDS) was compared with 23 depressed patients (DSM-III-R) and 129 healthy controls. Although the CFIDS patients had normal neuropsychological profiles, they significantly overestimated their ability (metamemory), performed significantly worse on tests of recall as context increased (e.g., recognition), made more errors when rehearsal was prevented, and had delayed mental scanning as memory load increased. The overall pattern indicated that CFIDS patients had a significant memory deficit, far worse than implied by CDC criteria. The pattern for CFIDS patients was consistent with temporal-limbic dysfunction and significantly different than depressed patients and control subjects.

Adult↗