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Biomedical subjects

F Fischer

Publications and source records attributed to F Fischer.

At least 91 records · Page 5Linked to original sources
PubMed1979

[Proliferative diabetic retinopathy for over twenty years without glomerulosclerosis (author's transl)].

Proliferative retinopathy and glomerulosclerosis (Kimmelstiel-Wilson disease), crucial prognostic features in determining morbidity and mortality of diabetics nowadays, appear to be closely related: joint inadence, parallel progression and similar histological findings. A report is given on four cases suffering from proliferative retinopathy for 20 to 26 years, yet without any signs of glomerulosclerosis. The patient are all advanced in age (68 and more) and in relatively good general condition, but have, tragically, been blind for many years. Hence proliferative retinopathy, though part of diabetic angiography, is proved to originate independently from glomerulosclerosis although apparently so closely related to this syndrome. Nothing can be said in explanation of this fact, neither on a metabolic nor an organic basis.

Aged↗
PubMed1979

Pain-induced alterations in the individual non-esterified fatty acids in serum.

Changes of individual non-esterified fatty acids in serum were studied in 7 metabolically healthy patients, suffering from idiopathic trigeminal neuralgia, who underwent electrocoagulation of gasserian ganglion under neurolepthypalgesia. The mean concentration of fatty acids increased by about 40% during the strong surgical pain stimulus. The increased lipolysis affected all individual fatty acids in proportion to the ratio of their presence in adipose tissue. The mechanism of pain-induced activation of lipase and possible consequences of alterations in individual non-esterified fatty acids are discussed.

Adult↗
PubMed1979

[Infusions emergencies following the administration of plasma substitutes -- analysis of case reports to the committee on drugs. The problems of medical statistics, prophylaxis and immediate therapy (author's transl)].

In the period 1967 to 1976 the Adverse Drug Reaction Committee of the Medical Association of the Federal Republic of Germany (AMK) received 323 reports of transfusion emergencies following the administration of colloid plasma expanders (dextran, gelatin, starch). The reports ranged from medium to severe cases. Nine percent of the reported cases had a fatal outcome. The data contained in these case reports could only be statistically analyzed within certain limitations as the reports were incomplete and other parameters necessary for a definite statistical evaluating were missing. Furthermore the results do not cover the following points: 1. What percentage of reactions to plasma expanders in W. Germany was reported? --2. What percentage can be attributed to the individual colloids within the entirety of these undesirable side effects? --3. What percentage of the individual colloids can be allocated to the varying degrees of severity of these reactions? -- Further limitations which complicated the analysis of the case reports are discussed individually. Despite these difficulties an attempt was made to analyse the parameters necessary in the diagnosis of acute transfusion emergencies and to compile a guide for the clinical symptomatology. Grading of reactions into four degrees of severity has proved useful both in terms of diagnosis and immediate therapy. The medical statistical evaluation presented in this paper gives an indication as to the significance of the observed side-effects and confirms the statement and recommendations made elsewhere in the literature. In these emergency cases life-threatening incidents appear to be more common than is generally assumed and the user is aware of. The incidence of product-specific emergencies can only be determined to some degree of accuracy by randomized prospective studies. These would have to be conducted with numerous strict guidelines. On the basis of the results presented here, these studies should be attended to with a sense of urgency. Regardless of the difficulties encountered in the evaluation of the case reports, guidelines as to the recognition of reactions, prophylaxis and immediate remedial therapy could be established. These would appear to suffice as urgently required comprehensive information for the nursing staff as well as all doctors. Recognizing side-effects and instituting immediate remedial therapy along the principles laid down in these guidelines can in most cases of severe reactions remove the acute threat to life.

Adolescent↗
PubMed1979

[Diabetic angiopathy. Proteinuria as an initial symptom].

Follow up studies in 19 diabetic patients with manifestation in the youth. Proteinurie within few years; later on nephropathy: 7 cases with glomerulosclerosis, 8 with arteriolosclerosis, 3 with pyelonephritis and 1 with chronic glomerulonephritis. In all cases retinopathy, very often coronarsclerosis, seldom peripheral and cerebral sclerosis. 14 patients died, mostly in young age in consequence of nephropathy. Proteinurie is a malignant symptom of diabetic angiopathy; in contrast to the retinopathy.

Adolescent↗
PubMed1978

[Proliferative retinopathy in growth-onset diabetes and in maturity-onset diabetes (author's transl)].

95 diabetics with proliferative retinopathy were divided into two groups according to the type of diabetes, Group I consisting of 25 cases of growth-onset diabetes and Group II of 70 cases with maturity-onset diabetes. A distinct tendency was observed in Group II cases towards a shorter duration of diabetes prior to the manifestation of retinopathy, i.e. less than ten years. The pre-proliferative phase of the retinopathy is similar in duration and manifestation in both groups. There is no difference in the ophthalmoscopic findings or development of proliferative retinopathy either, except that its course is more aggressive in Group I, in contrast to the slower course with longer remissions seen in Group II cases. Thus, the basic characteristics of proliferative retinopathy appear to be independent of the form of diabetes, in keeping with the concept of diabetes mellitus as a single disease entity.

Adolescent↗
PubMed1978

[Changes of circulation, blood gases, acid-base-and metabolism during neurolept-analgesia with and without beta-receptor blockers in electro coagulation of Gasser's ganglion (author's transl)].

The cardiovascular, blood gas, acid-base and metabolic changes occurring during operative stress were studied in 10 elderly, metabolically healthy patients, suffering from idiopathic trigeminal neuralgia, who underwent electrocoagulation of the gasserian ganglion under neuroleptanalgesia. In a group of 12 patients undergoing the same operative procedure and anesthesthetic management, we investigated the effects of administration of a beta blocking agent on these parameters. Intraoperative rises of blood pressure and tachycardia were prevented by intravenous administration of 0.4 mg Pindolol (Visken), whereas increases in the blood glucose levels at the end of the operation were the same. The increase of glycerol, free fatty acids and ketone bodies was markedly reduced after pretreatment with the beta blocker compared with the controlgroup. In the patients without beta blocker treatment pH and standard bicarbonate at the end of the operation were lower as the result of the stimulation of ketogenesis.

Acid-Base Equilibrium↗
PubMed1978

[Hormonal changes during electrocoagulation of the Gasserian ganglion under neuroleptanalgesia and the effects of administration of a beta blocking agent (author's transl)].

Hormonal changes, occurring during electrocoagulation of the Gasserian ganglion under neuroleptanalgesia, and the effects of intravenous administration of pindolol 0.4 mg on these changes were investigated in two groups of 10 and 12 patients of advanced age. At the end of the operation there were marked increases of the concentrations of catecholamines, a rise of the plasma cortisol and a fall of the serum insulin. The administration of the beta-adrenergic blocking agent did not induce any statistically significant changes of the determined hormones compared to the control group.

Basal Ganglia↗
PubMed1977

[Diabetic retinopathy: onset in pregnancy (author's transl)].

Retinopathy appeared during pregnancy, mostly in the last trimester, in 20 female diabetics. In some cases the retinopathy reappeared during the subsequent pregnancy, whilst in other cases it skipped one or two pregnancies. The retinopathy was mostly of a mild form and, in about half the cases, disappeared spontaneously post partum. In the remaining cases it remained stationary or subsided to a great extent, but certainly did not become progressive. Forms of angiopathy other than retinopathy remained in the background. No toxicoses, and no other complications were seen during pregnancy. Hence, pregnancy promotes or accelerates the onset of diabetic retinopathy, its influence on the course of the disease being favourable rather than harmful.

Female↗
PubMed1977

[Retinopathy and angiopathy in diabetes of fifty to sixty years duration (author's transl)].

A report is given on ten (seven female, three male) diabetis with uncommonly long duration of the disease. Diabetes had become manifest at an early age (mostly childhood) and, then, had continued for a period of fifty to sixty-one years. Eight patients suffer from retinopathy, two are free from it. Only three cases show nephropathy of moderate development and inconspicuous progression. Coronary sclerosis, peripheral sclerosis, and neuropathy recede with time. There is a surprising discrepancy of findings concerning retinopathy - on the one hand: simple retinopathy tending to spontaneous regression; on the other hand: malignant proliferating retinopathy. Uncommon also is the tarrying behaviour of nephropathy.

Adolescent↗
PubMed1976

[Diabetes mellitus: puberty and angiopathy (author's transl)].

It is inferred from a study of 140 cases of diabetes mellitus commencing between the ages of 10 and 17 that puberty causes the premative and accelorated appearance of angiopathy. The characteristic course of the angiopathy is not affected by puberty and does not necessarily persue an absolutely malignant form. It is genetically pre-determined and undergoes only insignificant enviornmental modifications subsequently.

Adolescent↗
PubMed1976

[Spontaneous regression of diabetic retinopathy (author's transl)].

A report is given on seventeen cases of spontaneous regression of diabetic retinopathy. The diabetes became manifest, without exception, at an early age, particularly in childhood. Regression came on slowly and inconspicuously, retinopathy disappearing completely in two thirds of the cases. Of the other forms of diabetic angiopathy only arterial hypertension was found. No case of specific nephropathy, but frequently chronic infections of the urinary tract, and intermittent proteinuria were observed.

Adolescent↗
PubMed1976

The results of "exercise therapy in coronary prone individuals and coronary patients".

The authors followed for at least two years 483 patients (430 coronary prone patients and 53 with proved coronary heart disease), to determine whether physical training could decrease coronary risk factors and improve exercise tolerance in the trained group as compared with the conventionally treated group (way of life, diet, drugs). There was no significant difference among the two groups for blood lipid profile, blood pressure (at rest and during exercise), functional capacity and mortality. In the authors' opinion this could be explained by the inadequate training program (45 minutes twice a week) and by a possible overlapping of the groups.

Blood Pressure↗
PubMed1976

[Ulstrasonic monitoring for early diagnosis of air embolism during neurosurgical procedures (author's transl)].

The sitting position of the patient offers many advantages to the neurosurgeon for operations at the posterior fossa, the upper cervical region, the Gasserian ganglion and the retroganglionic trigeminal root. Air embolism is however one of the greatest dangers during operations in this position. Air emboli occur more frequently than it is generally recognized. Most monitoring systems indicate the entrance of air at a late stage only. But early diagnosis and immediate therapy are of utmost importance. The use of an ultrasonic monitoring device for early diagnosis and the preoperative insertion of a right artrial catheter for immediate aspiration of the air are recommended.

Cardiac Catheterization↗
PubMed1976

[The retinopathy of the childhood diabetic (author's transl)].

From investigations of 141 patients, diabetic since childhood, diabetic retinopathy (angiopathy), shows strikingly contrasting forms of progress: (a) thoroughly benign (retinopathia simplex; partly regressive); (b) malign (retinopathia proliferans and glomerulosclerosis). The tendency to progression of diabetic retino- and angiopathy appears to be hereditarily determined and is modified, later, only to a certain extent by environmental factors.

Adolescent↗