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Biomedical subjects

F Flückiger

Publications and source records attributed to F Flückiger.

34 records · Page 2Linked to original sources
PubMed1991

[Value of magnetic resonance tomography after primary irradiation of carcinoma of the cervix uteri: evaluation of therapeutic success and follow-up].

This study investigates the reliability of magnet resonance imaging in the evaluation of response to therapy and in follow-up after primary irradiation (RTX) of uterine cervical carcinomas in 25 patients (follow-up eleven to 39 months). Most of the tumors showed six months after RTX a significant reduction of volume and signal intensity in T2 weighted images. 20/25 (80%) showed a total tumor regression, 5/25 (20%) had a residual tumor (all of them had a primary tumor volume higher than 50 ccm). Four patients got a recurrent tumor in follow-up. Residual and recurrent tumors showed like the primary in heavily T2 weighted images significant higher signal intensity than fibrosis. Therefore posttreatment fibrosis is distinguishable from residual or recurrent neoplasm. Early radiation fibrosis (less than 6 months after RTX) showed higher signal intensity than fibrosis in later stages. This fact may be the cause of false positive results in searching for residual tumor within the first six months after RTX. Our results indicate that magnet resonance imaging is a reliable method to evaluate tumor response after radiation treatment and to detect recurrent neoplasm. The results of a greater patient population over a longer period of follow-up will be presented in future.

Adenocarcinoma↗
PubMed1991

[Color-coded duplex sonography of dysfunctional kidney transplants. Correlation of the resistive index with the histopathologic results of biopsy].

The resistive index (RI) is used as a measure of the vascular resistance in renal allografts. The sample volume for the measurement can be positioned much more exactly with color duplex US than with duplex US, resulting in more precise values for the RI. To find out which pathologic changes lead to an increase of the RI, we correlated the RI with the histopathological results obtained in 43 biopsies. Our results show that it is not possible to differentiate between vascular and interstitial rejection on the basis of the RI because there is no statistically significant difference between the RI values caused by the two types of rejection. Distinct interstitial infiltration, edema of any origin, vascular changes and also chronic rejection and arteriolosclerosis lead to elevated RI. A good correlation was found between the elevation of RI and the severity of the vascular changes. Severe tubular and glomerular changes, cyclosporine toxicity, tubular necrosis, cytomegaly infection, glomerulonephritis and dysfunctions of other causes did not lead to elevation of the RI.

Adult↗
PubMed1990

[Color-coded duplex sonography and the resistive index in dysfunctional kidney transplants].

In a prospective analysis we performed 182 colour duplex US studies in 60 patients with renal transplants to determine the effects of different causes of graft dysfunction on the resistive index (RI) and the colour imaging pattern of the transplant arteries. Allografts with normal function, cyclosporin toxicity, cytomegaly infection, acute tubular necrosis, glomerulonephritis and postoperative functional nephrotoxicity showed normal RI (less than 0.7) and normal pattern of the arteries in colour duplex. Grafts with acute and chronic rejection, obstructive uropathy and arteriolosclerosis showed significant elevated RI and in colour duplex always a characteristic blinking of the arteries and a numerical reduction of the peripheral arteries. It seems that the assessment of an increase of vascular impedance is possible also with colour duplex US.

Adult↗
PubMed1990

[A solitary metastasis in the trapezium bone].

Carpal bone is an uncommon location for metastases, and diagnostic problems can occur when a solitary metastasis mimics acute arthritis or osteomyelitis clinically as well as radiologically.

Bone Neoplasms↗
PubMed1988

Ha-ras and c-myc oncogene expression interferes with morphological and functional differentiation of mammary epithelial cells in single and double transgenic mice.

We studied the effects of the tissue-specific and lactogenic hormone-dependent expression of the recombinant whey acidic protein (Wap)-ras and Wap-myc oncogenes on the differentiation of the mammary epithelium in transgenic mice. The histological appearance of mammary glands in pregnant, lactating, and postlactational animals and their ability to express milk protein genes were analyzed. Activated Ha-ras expression caused a decrease of milk protein synthesis during the lactation period. The formation of glandular epithelium and the postlactational regression of epithelial cells were not affected. c-myc expression impaired the development of the glandular epithelium, and milk protein synthesis was decreased strongly. Epithelial cell proliferation continued during lactation and postlactationally. Coexpression of both oncogenes in double transgenic mice synergistically affected differentiation and resulted in a high number of neoplastic foci. Palpable tumors were observed only after a latency of 3-4 months. Tumor cells utilize the Wap promoter hormone independently, express increased levels of Wap-ras and induce adjacent stromal cells to produce tenascin.

Animals↗
PubMed1988

[Pulmonary involvement in tuberous sclerosis].

The authors present a case of tuberous sclerosis with marked pulmonary involvement, confirmed by both radiological and pathological studies. The radiological manifestations and basic pathology of this rare condition are reviewed with emphasis on differential diagnosis.

Adult↗
PubMed1988

[Skeletal changes in tuberous sclerosis].

This paper is based on the skeletal changes which were found in six cases with confirmed tuberous sclerosis. The bone changes of this rare condition are summarised. The differential diagnosis is discussed.

Adolescent↗
PubMedDate not supplied

MR-imaging with Gd-DTPA in carcinomas of tongue, oro- and hypopharynx.

High-field MRI was performed in a series of 24 patients with squamous cell carcinomas of the tongue, oro- and hypopharynx. The value of contrast enhanced T1-weighted images in tumor staging was established prospectively. Non-contrast T1-weighted images did not provide sufficient tumor-delineation. Marked contrast enhancement produced by Gd-DTPA was observed in all carcinomas and in normal pharyngeal mucosa. In tumors of the tongue and upper pharynx clinical examination and ultrasound were equally sensitive as post-contrast MRI; in tumors of the lower pharynx the true tumor extension could be better assessed by contrast-enhanced MRI.

Adult↗