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Biomedical subjects

F Flam

Publications and source records attributed to F Flam.

At least 55 records · Page 3Linked to original sources
PubMed1994

Combination of granulosa cell tumour and carcinoid in an imitation of appendix vermicularis within a mature teratoma--a unique case.

A case of primary carcinoid of the ovary in association with an imitation of appendix vermicularis is presented. These elements were thus parts of a mature teratoma. In the other ovary a granulosa cell tumour with a similar morphology was found. Following surgery no additional treatment was administered and the patient is well 13 years after the diagnosis.

Aged↗
PubMed1994

Case report: choriocarcinoma presenting with brain metastases.

Although choriocarcinoma is a gynaecologic malignancy, it may well present with nongynaecologic symptoms. We present such a case with metastases to the lungs and brain. The malignancy had arisen in a full-term pregnancy ending nine months prior to admission. In female patients presenting with cerebral metastases, a pregnancy test will either confirm or dismiss the possibility of choriocarcinoma.

Adult↗
PubMed1994

Colour flow Doppler for gestational trophoblastic neoplasia.

Twenty-five consecutive patients referred to the Department of Gynecology and Obstetrics, Karolinska Hospital, Stockholm, because of gestational trophoblastic neoplasia (GTN) had colour flow Doppler performed. The examinations were performed transabdominally in the initial ten patients and transvaginally thereafter. Tumour vessels within the uterus were detected in eighteen patients (72%). A negative colour Doppler finding in patients with persistent disease could imply a diagnosis of choriocarcinoma rather than invasive mole, but all five patients belonging to this group responded promptly to chemotherapy. There seems to be a rough correlation between extent of uterine disease, as judged by colour flow Doppler, and response to chemotherapy.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1993

Successive activation of the platelet-derived growth factor beta receptor and platelet-derived growth factor B genes correlates with the genesis of human choriocarcinoma.

The hydatidiform mole is a benign disease of the placenta characterized by the absence of the maternal genome. Approximately 3% of the reported cases will develop into malignant choriocarcinoma. In situ hybridization analysis reveals that the paternal platelet-derived growth factor (PDGF) beta receptor gene is up to 2 orders of magnitude more active in cytotrophoblasts of the complete hydatidiform moles than in normal placentae. The transition between hyperplasia (complete hydatidiform mole) and neoplasia (choriocarcinoma) in these cells correlates with at least a 10- to 20-fold activation of the PDGF-B gene. Since the neoplastic cytotrophoblasts have maintained an abnormally high level of PDGF beta receptor expression, we propose that a deregulated PDGF autostimulatory loop is involved in the genesis of human choriocarcinoma from hydatidiform moles.

Choriocarcinoma↗
PubMed1993

IGF2 is parentally imprinted during human embryogenesis and in the Beckwith-Wiedemann syndrome.

The phenomenon of parental imprinting involves the preferential expression of one parental allele of a subset of chromosomal genes and has so far only been documented in the mouse. We show here, by exploiting sequence polymorphisms in exon nine of the human insulin-like growth factor 2 (IGF2) gene, that only the paternally-inherited allele is active in embryonic and extra-embryonic cells from first trimester pregnancies. In addition, only the paternal allele is expressed in tissues from a patient who suffered from Beckwith-Wiedemann syndrome. Thus the parental imprinting of IGF2 appears to be evolutionarily conserved from mouse to man and has implications for the generation of the Beckwith-Wiedemann syndrome.

Alleles↗
PubMed1993

Psychosocial impact of persistent trophoblastic disease.

The female identity of women who suffer from hydatidiform mole developing into persistent trophoblastic disease is threatened in two ways. The reproductive failure is shortly followed by a disease originating in the uterus requiring chemotherapy. Although somatic treatment results are excellent, the psychological effects may be severe and protracted. We conducted a study of 22 women who were between 6 months and 5 years after the end of successful treatment. It appeared that 19 women suffered from psychological sequelae. The three oldest women of the study group, 50 years or older, belonged to the group of women demonstrating signs of prolonged psychological effects.

Adaptation, Psychological↗