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Biomedical subjects

F Follath

Publications and source records attributed to F Follath.

At least 19 recordsLinked to original sources
PubMed1979

[Delayed elimination of aminoglycoside antibiotics: importance for clinical use].

In 7 patients the elimination of amikacin (4), tobramycin (1) and gentamicin (2) in serum and urine was measured over several days after cessation of therapy. All three aminoglycosides showed multicompartmental pharmacokinetics with a terminal half life ranging between 46 and 150 hours. Using computer simulations, it is shown that slow drug accumulation in the body is to be expected during multiple dose therapy. Therefore, the indiscriminate use of these drugs should be avoided and the duration of therapy kept as short as possible.

Amikacin↗
PubMed1979

[Cardiac tamponade in malignant tumors].

Among 40 patients with cardiac tamponade observed over the years 1972--1978, 23 (57.5%) had a neoplasm as primary cause of illness. The most common etiology was bronchial carcinoma (13). In 9 cases cardiac tamponade was the first clinical symptom of the tumor. Evacuation of the pericardial fluid by puncture (3), surgical drainage (6) and left parasternal insertion of a plastic catheter (12) brought rapid relief from symptoms in all cases. Six patients survived 3--6 months, while another two have now been followed up for over 5 years. Diagnostic problems and therapeutic possibilities in malignant pericarditis are discussed.

Adult↗
PubMed1979

Multicompartment pharmacokinetics of netilmicin.

The pharmacokinetics of a single dose of netilmicin (NM) was studied in 6 healthy volunteers. Elimination of the drug was followed in serum and urine for 24 h and 72 h, respectively. NM concentrations were measured with a modified radioenzymatic assay. A three compartment open model was employed to calculate the pharmacokinetic parameters. Following the rapid initial distribution, biphasic elimination with half lives of 1.99 (t 1/2 beta) and 36.89 h (t 1/2 gamma) was demonstrated. Measurable amounts of NM were excreted in the urine for up to 72 h. The volume of distribution at steady-state (Vdss) of 0.68 l/kg was 3 to 4 times larger than previously reported for this antibiotic. NM plasma clearance was 91 ml/min and the renal clearance was 67 ml/min. The data indicate that on repetitive dosing the amount of drug in the body would be considerably underestimated if the prolonged terminal elimination phase were not taken into account. During prolonged treatment, accumulation of NM in renal and other tissues is likely to occur, as has been described for other aminoglycosides. The possible consequences of this pharmacokinetic behaviour are discussed.

Adult↗
PubMed1979

Progression of mild mitral stenosis and incidence of restenosis after open commissurotomy: a study using echocardiography.

Thirteen patients with mild mitral stenosis and 21 asymptomatic patients after commissurotomy were studied by echocardiography in order to assess the rate of progression of mitral stenosis and the incidence of restenosis after successful open mitral commissurotomy. In the group with mitral stenosis there was a decrease of the diastolic closing velocity (E-F slope) from 35.7 to 29.5 mm./sec. (p less than 0.0005) over a period of 37 months. In 23% of the patients the stenosis increased significantly (p less than 0.0005) by echocardiographic parameters. Forty-eight months after commissurotomy we noted a significant over-all slowing of the diastolic closing velocity (from 52.6 to 44.8 mm./sec., p less than 0.0005) and a decrease of the mitral valve closure index DE/MAIC (from 1.7 to 1.5, p less than 0.0025). Five of 21 patients (24%) showed a change in one or both of these parameters which was greater than 2 standard deviations of the mean change. Based on echocardiographic criteria, we conclude that patients with mild mitral stenosis and asymptomatic patients following successful commissurotomy need only be checked approximately every 3 years.

Adult↗
PubMed1978

[Fever of long standing in atrial myxoma].

A 39-year-old man is described who presented with the unspecific signs of systemic disease (elevated erythrocyte sedimentation rate, increased gamma-globulins, positive rheumatoid factor; clubbing, splenomegaly) and with fever whose origin remained undiagnosed for 8 years despite numerous investigations. Later in the course of the disease, the signs of mitral stenosis appeared, suggesting left atrial myxoma even in the absence of arterial embolization. This diagnosis was established by echocardiography and confirmed by angiocardiography as well as at operation, after which all the systemic signs and symptoms disappeared.

Fever↗
PubMed1978

Intrinsic sympathomimetic activity of beta-adrenoceptor blocking agents.

The pharmacological methods used to assess the intrinsic sympathomimetic activity (ISA) of beta-blockers are discussed. The clinical relevance of ISA to respiratory function, peripheral resistance and cardiac function is reviewed. It appears doubtful whether ISA is always of predominant clinical significance and an alternative explanation is offered for many clinical effects observed with certain beta-blockers, e.g. pindolol, oxprenolol, tolamolol, metoprolol, etc. Some effects of these beta-blockers resemble those of labetalol, a new drug with both alpha and beta-blocking activity. Some clinical effects of certain beta-blockers are more likely to be due to alpha-blocking activity than to their ISA.

Adrenergic alpha-Antagonists↗
PubMed1977

[Determination of serum digoxin: a path to better control of therapy?].

The usefulness of serum digoxin measurements in the diagnosis of digitalis toxicity was studied prospectively in hospitalized patients. Serum levels were increased above 2 ng/ml in 28 of 32 cases with digoxin-induced arrhythmias and/or gastrointestinal symptoms, whereas only 1 of 35 non-toxic patients had an abnormal serum concentration. There was, however, no direct relationship between the type of toxic manifestation and absolute values of serum digoxin.

Arrhythmias, Cardiac↗
PubMed1977

[Echocardiography in infectious endocarditis].

The effectiveness of echocardiography was evaluated in 36 cases of anatomically documented infective endocarditis during the period 1972 to 1976. Valvular vegetations were found in 47% and destructions in 58% of this group. Echocardiography is a valuable tool in the certification of clinically suspected infective endocarditis and in the delineation of a subgroup of patients with valvular vegetations and destruction of aortic and mitral valve leaflets. Echocardiography may therefore play a decisive role in the selection of patients for surgical intervention despite active infection.

Adult↗