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Biomedical subjects

F Franceschini

Publications and source records attributed to F Franceschini.

At least 73 records · Page 4Linked to original sources
PubMed1984

Lymphadenopathic and oropharyngeal Kaposi's sarcoma in a drug addict with acquired immunodeficiency syndrome. Immunological abnormalities in peripheral blood and lymphoid tissue.

Lymphocyte subsets were analyzed in peripheral blood and lymph nodes from a drug-addict with acquired immunodeficiency syndrome (AIDS) presenting with disseminated lymphadenopathic and oropharyngeal Kaposi's sarcoma. At the onset of disease, hypergammaglobulinemia, increase of OKT8+ T cell subset and reversal of OKT4/OKT8 ratio were found in the blood. At the same time, lymph nodes displayed, besides Kaposi's sarcoma, marked follicular hyperplasia, plasmocytosis and increase of OKT8+/Leu 2a+ T cells within follicular centers. These results are interpreted to indicate that at an early stage of disease the major tissue alterations took place within follicular centers and consisted of both B cell activation and T suppressor cell reaction. These changes correlated with immunological abnormalities observed in peripheral blood. Immunohistochemical investigation of lymphoid tissue may be useful to detect AIDS patients at an early stage.

Acquired Immunodeficiency Syndrome↗
PubMed1983

[Mönckeberg's mediocalcinosis associated with Raynaud's phenomenon].

A case of Mönckeberg's arteriosclerosis associated with Raynaud's phenomenon and diabetes is reported. It is probable that Mönckeberg's arteriosclerosis could provoke a Raynaud's phenomenon when predisposing local conditions, such as microvasculature and/or haemorheological alterations, are present. Finally our findings seem to demonstrate that xeroradiographic investigation is most important for the early diagnosis of the disease.

Aged↗
PubMed1983

[Migration of hepatic macrophages after cyclophosphamide or whole body irradiation].

The liver macrophages behaviour after cyclophosphamide or total-body irradiation (1000 rads - 60Co) has been studied in the mouse previously injected with colloidal carbon. In these conditions an early increase of carbon-laden macrophages in the central zone of the liver lobules has been observed. Carbon-containing mononuclear cells were also observed in the lumina of the hepatic collecting system. Possible implications of these findings are discussed; a migration of macrophages from the liver to elsewhere is suggested.

Animals↗
PubMed1983

[Ultrastructural observations of cat cortical neurons, labeled by the retrograde method, 8 days after injection of horseradish peroxidase].

The ultrastructural characteristics of cat's cortical neurons labeled by retrograde transport of horseradish peroxidase (HRP) have been studied; the cats were sacrificed 8 days after the injection of the enzyme. The aim of this study was principally to observe the evolution of neurons in which HRP had been assumed in diffused as well as in granular form - "diffuse-granular HRP neurons" -, or only in diffused form - "Golgi-like neurons" -. The results obtained show the scanty presence of diffuse-granular HRP cells and the contemporary presence of two populations of Golgi-like cells. In this study is underlined the difference between the observations conducted on specimens from cats sacrificed 48 hours or 8 days after the injection of the HRP.

Animals↗
PubMed1982

[Skeletal changes in intermediate beta-thalassemia. Clinical and radiological study].

Bone changes of varying degree and distribution were observed by the Authors in 10 carriers of beta-thalassaemia intermedia in skull, ribs, hand, elbow and knee bones. When they are present, skeletal changes are the same of homozygous beta-thalassaemia, but less marked and spread. Instead, symptomatology is more homogeneous, usually characterized by mild anaemia and morphological changes of red cells with haemoglobin values in the 6-11 g/dl range, splenomegaly, jaundice, gallstones, crural ulcers. The clinical state goes through the asymptomatic condition to a more severe condition with typical appearance of Cooley's anaemia.

Adolescent↗
PubMed1982

[A new case of hemoglobin Lepore-beta-thalassemia disease].

The A. relate on a case of disease from Hb Lepore-heterozygous beta thalassemia observed in an italian family originated from Campania. The patient is a boy 16-year old who shows a clinical picture similar to that of Cooley's disease. The electrophoretic study of the hemoglobin has evidenced a double heterozygosis Hb-Lepore-beta thalassemia. Enlarging the examination to the other components of the strain, also the sister of the propositus shows the same disease, while the brother and the mother get a little amount of Hb Lepore. The father gets heterozygous beta-thalassemia. The negatively of the sickling test "in vitro" excludes tha presence of HbS in all components of the family. The radiological examination of the skeleton of the propositus evidences interesting analogies with the skeleton alterations observed in the subjects affected with Cooley's disease and scarcely blood-transfused.

Adolescent↗
PubMed1980

Particular aspects of seminiferous tubules at early puberty.

In the seminiferous tubules of patients at early puberty we have observed Sertoli cells showing an homogeneous aspect. In the cytoplasm of some of these elements dense bodies, which present a particular structure and shape, have been recognized. As far as the germ cells, we can find spermatogonia, spermatocytes and spermatids at various developmental stages. The presence of intercellular bridges among the germ cells and of binucleated spermatids with only one acrosome is a characteristic and fairly frequent finding in our specimens, obtained from normal patients.

Adolescent↗
PubMed1980

Further contributions about the use of the horseradish peroxidase (HRP) in the ultrastructural study of the olivary neurons of cat.

In order to recognize with E.M. the specific aspect of HRP in olivary neurons of cat, we have used newborn animals twenty-four, forty-eight hours old. The observation of these neurons has allowed us to see a numerous series of dense bodies various in size and density; these bodies have never been found in similar neurons from adult cats or from newborn cats not treated with HRP. These structures could represent the equivalent of an intraneuronal storage of enzyme, whose presence had been confirmed by O.M.

Animals↗
PubMed1979

The retrograde transport of horseradish peroxidase: problems in the interpretation of its ultrastructural aspects.

In this study we consider critically the use of HRP in research on the ultrastructure of the Central Nervous System. In fact, although controls make by optical microscope on semi-thin sections made us certain that some of the neurons were definitely marked with the enzyme, when the same specimen was observed by electron microscope, in no case was it possible for us to distinguish any particular aspect of the ultrastructural morphology of labelling within neurons.

Animals↗