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Biomedical subjects

F Frassica

Publications and source records attributed to F Frassica.

5 recordsLinked to original sources
PubMed2002

Skin metastasis from conventional giant cell tumor of bone: conceptual significance.

A conventional giant cell tumor of the proximal femur recurred twice locally and developed pulmonary nodules. The lung lesions were felt to be an example of "benign" metastases. Eight months after the initial presentation, the patient developed a single skin nodule on the contralateral leg. Histologic features of the skin nodule showed conventional giant cell tumor identical to the bone lesion. This nodule is a manifestation of arterial metastasis typical of any malignant tumor and seemingly contradicts the concept of "benign" metastasis.

Adult↗
PubMed1999

Autogenous onlay grafting for enhancement of extracortical tissue formation over porous-coated segmental replacement prostheses.

BACKGROUND: Prosthetic reconstruction with extracortical bone-bridging is an effective method of limb salvage after resection of a malignant or locally invasive benign bone tumor. Use of cancellous bone graft alone is less effective in achieving extracortical bone-bridging. The present study was performed to investigate the effects of a corticocancellous onlay graft on bone and soft-tissue formation over a porous-coated replacement prosthesis in the mid-diaphyseal region of canine femora. METHODS: Bilateral resection of a six-centimeter segment of the femoral diaphysis and reconstruction with a porous-coated segmental prosthesis was performed in six mongrel dogs. In one limb (the experimental side), eight strips of corticocancellous bone were evenly placed around the junctions between the femur and the prosthetic surface. Cancellous bone was placed under and between the strips of cortical bone. No graft was used in the other limb (the control side). The animals were followed for twelve weeks, with sequential assessments of load-bearing and radiographic evaluation. Biomechanical, histological, and microradiographic analyses of the specimens were performed after death. RESULTS: On the control side, load-bearing at four weeks postoperatively was significantly decreased compared with the preoperative value (p<0.05); no difference in these values could be detected on the experimental side. Both the area of the callus and the contact area between the bone and the prosthetic shoulder were greater on the experimental side (p<0.05). The mechanical stiffness and the maximum torque at failure of the extracortical bridging tissue across the junction between the bone and the prosthetic shoulder were eighteen (p<0.007) and five times greater (p<0.05), respectively, on the experimental side. CONCLUSIONS: Extracortical bone-bridging was accomplished with corticocancellous onlay bone-grafting. Without bone-grafting, bone formed only occasionally. Bone-grafting also enhanced the formation of a soft-tissue capsule around the prosthesis.

Animals↗
PubMed1998

Intraarticular epithelioid sarcoma.

A case of an intraarticular epithelioid sarcoma is presented. The patient was a 35 year old man who presented with a 10 months history of a chronic monoarthritis. The MRI showed a diffuse lesion involving the synovial membrane of the knee. There was a marked increased signal on T2 weighted images. Most epithelioid sarcomas involve the subcutaneous tissues of the hands or feet. This presentation is unusual and this entity should be considered in the differential diagnosis of an intraarticular proliferative process.

Adult↗
PubMed1998

Condensing osteitis of the clavicle: case report and review of the literature.

Osteitis condensans of the clavicle is a rare condition characterized by pain in the shoulder and often limitation of motion of the shoulder. The medical history and results of the physical examination, laboratory data, and radiographic studies (including computed tomography and magnetic resonance imaging), often establish the diagnosis. Patients who have slight or no pain usually require no treatment. Varying results have been reported for many different methods of treatment, including surgical excision, chemotherapy, antibiotics, nonsteroidal anti-inflammatory medications, radiation, local corticosteroid injection, and physical therapy. A typical case report and the differential diagnosis for condensing osteitis of the clavicle are presented.

Accidental Falls↗