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Biomedical subjects

F G Ellis

Publications and source records attributed to F G Ellis.

At least 19 recordsLinked to original sources

Splenic artery aneurysm embolisation--the preferred technique to surgery.

A case of embolisation of a splenic artery aneurysm is presented. The aneurysm and proximal splenic artery were successfully occluded with steel coils and there were no associated complications. Transcatheter embolisation-should be the treatment of choice for splenic artery aneurysms. The procedure carries less morbidity than surgery and more importantly allows preservation of the spleen and its function.

Aneurysm↗

Late rupture of ligated common iliac arteries.

Late rupture may follow simple ligation of the common iliac arteries after aortobifemoral grafting. Oversewing the origins of the arteries may prevent this rare but dangerous complication. A CT scan is recommended to investigate unexplained abdominal pain following aortic surgery.

Aged↗

The urological complications of 1000 renal transplants.

Two hundred and one urological complications have been diagnosed and treated in 123 transplant recipients in a series of 1000 consecutive renal transplant operations (overall incidence 12.5%). Obstructive uropathies and urinary fistulae accounted for 95% of these complications and all of the mortality (22%). Details of management and patient and graft survival are given. A relationship between mortality from a urological complication and steroid dosage was found. A 30% incidence of recurrent or secondary urological complications was also noted with correspondingly worsened prognosis. Early diagnosis followed by early aggressive surgical treatment is advocated.

Adolescent↗

Short-term cadaver kidney preservation.

200 consecutive human cadaver kidneys were preserved using 6 different techniques. Some attempt was made in the clinical situation to assess donor pre-treatment and postoperative specific recipient treatment to encourage immediate renal function. Provided the warm time was less than 60 min and the cold time less than 12 hours, intraarterial flushing with a crystalloid or colloid solution combined with pre-treatment of the donor and postoperative fluid load/frusemide drive to the recipient gave the best results.

Cadaver↗

Clinical evaluation of a rosette inhibition test in renal allotransplantation.

The formation of spontaneous rosettes by peripheral blood or spleen mononuclear cells when incubated with sheep red blood cells has proved a useful way of assessing the potency of immunosuppressive drugs and antilymphocyte sera in vitro. A test employing the inhibition by antilymphocyte globulin (A.L.G.) of spontaneous rosette formation around peripheral blood mononuclear cells is described. This has been used to assess the degree of immunosuppression in patients with renal allografts and uraemic patients on regular haemodialysis.Twenty-three patients with renal allografts had 21 clinically diagnosed episodes of rejection. In none of these rejection episodes was the minimal inhibitory concentration (M.I.C.) of A.L.G. (that necessary to reduce the spontaneous rosette formation of peripheral cells by 75%) less than 1/50,000. Nineteen patients had no rejection episodes during 57 patient/months of continuous observation while the M.I.C. was at a greater dilution than 1/50,000. The test has therefore been of great value in suggesting when an individual is capable of rejecting his graft, and allows the dose of immunosuppressive drugs to be adjusted to a minimum in a controlled fashion. It has been of use in diagnosing rejection in the anuric patient, when the distinction between rejection, urinary tract obstruction, and infection is particularly difficult.Fifteen patients maintained on regular haemodialysis for more than a year had, as judged by this technique, less reactive lymphocytes than normal healthy controls. The degree of immunosuppression was not as great as in the patients on full immunosuppressive regimens.

Animals↗