[Kaposi's angiosarcomatosis in the indigenous population of Algeria].
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Biomedical subjects
Publications and source records attributed to F G Marill.
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We have reported 5 cases of dermatophytic disease observed in Algiers. We insist on three characteristics of the disease: 1. - the familial predisposition; 2. - the deficiency of the cell-mediated immunity while humoral immunity remains apparently intact with high levels of IgE; 3. - the seriousness of the disease: one of our patients has a cerebral abscess, while another died despite the grisefulin therapy.
A verrucose dermatitis of the face, accompanied by onychomycosis was observed in a 30 years old male living in Algeria. He was born there and 15 years previously he had been treated successfully for "Dermatophytic disease" due to Trichophyton verrucosum. A deficiency in his cellular immune mechanism was noted at that time. On this occasion Hendersonula toruloidea was isolated from facial lesions and affected nails. The infection of the face, but not the nails, responded to treatment with amphotericin B. In the facial lesions, the fungus was present as single cell units sometimes with a false bud or a short hyphal extension. Cross walls were occasionally present but the cell walls were not pigmented. Intratesticular inoculation of the isolates to guinea pigs resulted in an infection in which the morphology of the fungus conformed to that found in the facial lesions. In cultures, the isolates of H. toruloidea conformed to the descriptions in literature, although pycnidia were not formed.
An 18-year-old young man, presents multiple areas of poikilodermia since 1 year of age, and papules like flat warts essentially on the back of his hands and feet, since 10 years of age. The examination of 16 of his closest relatives led us to discover 1 case of poikilodermia and acrokeratosis verruciformis, 1 case of poikilodermia and 3 cases of acrokeratosis veruciformis. Observations on the association of poikilodermia and acrokeratosis verruciformis have already been reported in the literature as well as comparable morphological fact, but without family lesions and without histological examinations. Thus, rare patients are presenting both congenital pikilodermia and acrokeratosis verruciformis. In the families of 3 of these patients, some members are similarly afficted, whereas others present independently either poikilodermia or acrokeratosis. In several reports in the literature and in our cases, the histological picture of verruciform papules was the same as Hopf's acrokeratosis verruciformis. These particularities led us to consider the association of Hof's and Thomson's diseases as an entity.
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