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Biomedical subjects

F G Renger

Publications and source records attributed to F G Renger.

9 recordsLinked to original sources
PubMed1985

[Drug-induced liver damage from a clinical viewpoint].

Biotransformation of xenobiotics is a life saving function of the liver. As a consequence of the tremendous development of new and highly effective drugs this function is frequently overburden. In recent years the number of patients with pharmocotoxic liver damage has become greater than that of patients with viral hepatitis. The liver answers xenobiotic overcharge by a limited spectrum of functional, morphological and clinical reaction patterns that can be caused also by other noxious agents. The manifestation of liver damage depends on a variety of factors such as properties of the drug, mode of administration, reactivity of the whole organism and of the liver as the target organ. From the clinical point of view, xenobiotics can be divided into compounds with foreseeable liver damage and into others in which liver damage is not foreseeable as well as into drugs which produce mainly cholestasis and others in which hepatitis dominates. Mixed patterns are possible. For clarifying diagnostic, differential diagnostic and therapeutic problems a graduated program is proposed. Prophylactic measures are based on this program. The increase of pharmacotoxic damage of the liver and other organs and the expected development leads to consequences and recommendations in health care.

Chemical and Drug Induced Liver Injury↗
PubMed1983

[Clinical aspects of acute hepatitis].

The definition of hepatitis is based on morphological criteria. The constellation of biochemical findings informs about form, severity and course. A minimum diagnostic programme allows to clarify typical cases. Aetiopathogenetically the feature of a hepatitis can be evoked by numerous noxae. At present we know virus A, virus B and the group non-A/non-B as hepatotropic viruses. From the latter we succeeded in delimitation of a virus hepatitis C. The virus hepatitis as cyclic infectious disease has various forms of course. They are expressed above all by dose and virulence of the virus, by mode of infection and immune defence of the organism of the host. In an initial complete picture with prodromi and jaundice there is in most cases a favourable prognosis with complete cure, whereas mitigated initial courses have a high tendency to chronicity. As to the three most important virus hepatitides the essential parameters and data as well as the differential-diagnostic possibilities are compiled.

Acute Disease↗
PubMed1983

[NANB-hepatitis associated marker ("C") in hemophilia].

Using an immune system isolated from a defined NANB epidemy we could find such markers in 29 of 71 patients (41%). The greater number of the antigen speaks in favour of a large pool of healthy carriers. The small number of patients with antibodies may be explained by the low sensibility of our test which detects only antibodies with high titers. According to this analysis of NANB associated immune markers the clinical importance of this infection in haemophiliacs seems to be small. Statements concerning the chronicity of the disease can not yet be made because of the preliminary character of this random test made in a holiday camp of haemophiliac children.

Adolescent↗
PubMed1982

[The history of hepatology from Galen to Frerichs].

The history of research in hepatology reflects the development of medicine as a whole. Both demonstrate the importance of technical equipment as a prerequisite and the dependence upon the level of the adjoining sciences. The prominent achievements of some scientific schools and of outstanding scientists--concentrated in their publications--can be compared with annual rings of the permanently growing tree of knowledge in hepatology. In the presented paper the author outlines the essential scientific periods and the results achieved within two thousand years considering their close interrelations.

Germany↗