Biomedical subjects

F García Montes

Publications and source records attributed to F García Montes.

7 recordsLinked to original sources

PubMed2002

[Effects of peripheral functional electrostimulation in obstructive bladder instability].

INTRODUCTION: The aim of this study was to assess the effects of peripheral functional electrical stimulation (FES) in patients with detrusor instability (DI) secondary to obstructive Benign Prostatic Hyperplasia (BPH). SUBJECTS, MATERIAL & METHODS: Nine patients with urodynamically proven DI secondary to BPH were investigated. Sensory and pudendo-anal reflex thresholds were determined in each patient to individually optimise FES. A standard fill cystometry was then performed and individually optimised FES was given when an unstable detrusor contraction occurred. Non stimulated contractions were used as controls. The effects of FES were analysed by measuring the mean area under the unstable pressure curves with and without FES and were expressed as percentage suppression. RESULTS: The percentage suppression in the mean area under the curves after stimulation was < 10%. There was no statistically significant difference between controls and FES using a two tailed, paired students t-Test (p > 0.1) at 95% confidence level (p > or = 0.05). CONCLUSION: FES did not significantly suppress unstable bladder contractions in patients with DI secondary to BPH. This finding suggests that obstructive DI does not depend on sacral reflex mechanisms and supports the view that it has a peripheral pathophysiological origin (myogenic and/or nerve endings).

Electric Stimulation Therapy↗

PubMed2000

[Does primary melanoma of the bladder exist?].

Primary melanoma of the urinary bladder is a rare neoplasm to which very strict diagnostic criteria apply. Although reports of previous cases exist, these criteria have yet to be met. We report a case of a young lady from whom a malignant melanoma of the bladder was resected. This was presumed to be primary as detailed investigation failed to find any other site from which metastases could have originated. We discuss the diagnostic criteria of this entity and stress the difficulty in conclusively demonstrating that, despite some of these criteria being met, a lesion such as this is primary in origin. This case could be the longest surviving patient with primary melanoma of the bladder, however we will never be able to prove that spontaneous regression of an undiagnosed extravesical primary malignant melanoma did not occur.

Adult↗

PubMed1999

[Aqueous diuresis and prophylaxis of recurrent nephrolithiasis].

Crystal precipitation in urine results from factors such as ionic strength, pH, soluble complexes formation, formation site and retention of initial solid particle. Among the most frequent causes are poor diuresis and changes in urine pH, their influence being quantified in different ways. Effects of water diuresis such as prophylaxis for urinary calculi are due to the intrinsic properties of the water contained in the urine, solid particles dragging, action on urine infection and changes in urine pH. Urinary flow has an influence on pH, so that its decrease coincides with concentrate urine and low pH, whereas its increase involves the presence of dilute urine and high pH. The purpose of this study is to understand the relationship between increased urine volume due to greater water intake and changes in urine pH, as well as the physiological intervening mechanisms.

Diuresis↗

PubMed1997

[Renal neuroadrenergic effects. Part I. Renal ischemia caused by sympathetic stimulation and risk factors of cadaver donor].

Functional impairment of transplanted kidneys may occur due to circumstances related either directly or indirectly to the donor, the graft or the receptor. In most publications, renal damage is frequently attributed to ischaemia phenomena, mainly host ischaemia, either because of intraoperative interruption of blood flow for an exceedingly long interval, until perfusion and cooling of the removed kidneys, by the duration of cold ischaemia for organ preservation, or during the implant procedure. Also due to the activation of neuroadrenergic reflexes as a consequence of the mechanical stimulation of sympathetic nervous endings during dissection of the vascular pedicle. Earlier studies in animals have demonstrated that direct, low frequency electric stimulation of the splanchnic nerve involves reversible changes in sodium renal excretion, but it does not modify glomerular filtration; when nerve stimulation is done with high frequency there is a decline of renal blood flow and glomerular filtration. The present study tries to associate some of the causes of hot ischaemia during the agony of the corpse donor and to evaluate those that may be caused by sympathetic efference during removal.

Cadaver↗

PubMed1997

[Renal neuroadrenergic effects. Part II. Experimental model and results].

The stimulation of renal innervation activates vasoconstrictor mechanisms that compromise the parenchyma. In order to know the intensity and duration of these effects continuous electric stimulation was applied to the greater splanchnic nerve in 14 dogs for half an hour, completing both a pre and post monitoring of equal duration; creatinine clearance (Crc) and urine volume per minute (UVM) were determined; blood pressure (BP), heart rate (HR), respiratory rate (RR), and also central venous pressure (CVP) in 7 animals were permanently recorded. Crc and UVM significantly decreased during the initial 10 minutes stimulation (p < 0.001); over the following 10 minutes only Crc decreased (p < 0.01) and during the final 10 minutes there were no differences in the two controls. BP declines significantly during the first 10 minutes of stimulation (p < 0.001), but then increased for the remaining 20 minutes to values that showed no significant differences relative to measurements during monitoring pre- and post-stimulation. CVP, HR and RR recordings showed no significant differences from the two controls, relative to each other or to the period of stimulation after the maximum initial effects have disappeared.

Animals↗

PubMed1997

[Renal neuroadrenergic effects. Part III. Discussion and conclusion].

Electric stimulation of the greater splanchnic nerve produced short-lasted maximum effects on the renal function ranging between 4 to 8 minutes, during which glomerular filtration and diuresis were annulled, to later increase up to values close to those of the controls in spite of stimulation being maintained, and become stabilized after discontinuation at values similar to the previous control. Analogous changes occurred in blood pressure, central venous pressure, heart and respiratory rates, which consisted in maximum effects during the first minute of stimulation, to immediately initiate a gradual return to control values with fluctuations that translate the activation of regulatory mechanisms. These results show that neuroadrenergic effects due to electric stimulation of the greater splanchnic nerve which cause vasoconstriction and ischaemia of the renal parenchyma, as well as other cardiovascular alterations, are significant but short-lasted, suggesting that they do not necessary result by themselves in irreversible organic lesions.

Blood Pressure↗

PubMed1993

[Medical and surgical aspects of renal lithiasis].

Over the last ten years a true revolution has developed in the resolution of renal and excretory tract calculi. Modern technology has made available to urologists a wide variety of procedures to be used for the fragmentation and removal of calculi, providing few complications, and more satisfaction and speed. The results have surprised urologists, patients and the entire community, up to the point where all interest in the etiological diagnosis and medical management of the lithiatic condition has been lost. Treatment, however, can only be considered complete when formation of new calculi is stopped; and progress to achieve this objective has also been relevant. The purpose of this paper is to explain the reasons for which surgical and medical management should not be competitive but complementary. Surgical procedures are directed to existing calculus, whereas medical measures focus on prophylaxis.

Combined Modality Therapy↗