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Biomedical subjects

F Ghazi

Publications and source records attributed to F Ghazi.

7 recordsLinked to original sources
PubMed1994

Molecular and biological characteristics of echovirus 22, a representative of a new picornavirus group.

Recent sequence analysis revealed that the human pathogen echovirus 22 (EV22) is genetically distant from all the other picornaviruses studied to date (T. Hyypiä, C. Horsnell, M. Maaronen, M. Khan, N. Kalkkinen, P. Auvinen, L. Kinnunen, and G. Stanway, Proc. Natl. Acad. Sci. USA 89:8847-8851, 1992). We have further characterized the biological properties of the virus and show here that the virion has properties similar to those of other picornaviruses. However, the protein composition is unique, in that most copies of one of the three major capsid proteins, VP0, do not undergo the further processing to VP2 and VP4 observed during the maturation of the virus in previously studied picornaviruses. Alignment of the capsid protein sequences with those of other picornaviruses revealed, furthermore, that the VP3 polypeptide contains an apparent insertion of approximately 25 amino acids at its amino terminus. An arginine-glycine-aspartic acid (RGD) motif is found in VP1, and by using synthetic peptides, it was shown that this sequence plays a role in cell surface receptor recognition. Finally, EV23 was shown to share remarkable identity with EV22 in certain parts of the genome and also belongs to this previously unrecognized picornavirus group.

Amino Acid Sequence↗
PubMed1992

Nursing and midwifery research: making it happen.

The organisation of a series of research awareness workshops for nurses and midwives in the North East Thames Regional Health Authority is described. The workshops, which aim to 'demystify' nursing research for practitioners, are particularly pertinent in view of government and nursing drives to raise the profile of research. Evaluations from workshop participants have shown a high degree of satisfaction with content and presentation.

Clinical Nursing Research↗
PubMed1989

Ebstein's anomaly: natural and unnatural history.

Clinical features and natural history were analyzed in 30 patients with Ebstein's anomaly (mean age 26 years, range 1.5-58 years, 53% females). The main presenting symptoms were dyspnea and fatigue (83%). At presentation, there were six patients (20%) in New York Heart Association Functional Class (NYHAFC) I, nine (30%) in NYHA-FC II, and 15 (50%) in NYHA-FC III or IV; 12 patients (40%) were cyanotic. Common auscultatory findings were widely split second heart sound in 21 (70%), third heart sound in 14 (47%), fourth heart sound in 16 (53%), and a systolic murmur in 22 (73%). Right bundle branch block was present in 21 (70%), documented supraventricular tachycardia in seven (23%), and Wolff-Parkinson-White syndrome in three (10%). Catheterization was performed in 93% without complications. Fourteen patients were treated surgically (12 [86%] in NYHA-FC III or IV, 10 [71%] with associated anomalies); tricuspid valve replacement was performed in eight, atrial septal defect repair in two, accessory pathway ablation in two, right atrial plication in one, and automatic cardioverter defibrillator implantation in one. Surgical treatment improved 10 patients from NYHA-FC III or IV to NYHA-FC I or II. Death occurred in nine patients (five treated surgically and four medically); four of these deaths were sudden. In the eight patients who had tricuspid valve replacement, there were one operative and two late deaths. The authors conclude that surgical therapy with tricuspid valve replacement improves the clinical status of patients who are severely ill. Risk of sudden death remains an important problem in patients with Ebstein's anomaly regardless of severity of the disease and mode of treatment.

Adolescent↗
PubMedDate not supplied

Monitoring research in a nursing college.

The increasing profile of research in nursing has demanded that monitoring and advice-giving facilities for prospective researchers become more formalised and rigorous. This article describes how a nursing college has responded to the challenge by forming a Research, Ethics and Consultancy Committee, and sets out the important work it has completed in the two years since its inception.

Faculty, Nursing↗
PubMedDate not supplied

Auditing student practice placements.

This article describes an action research project which analysed the development of a single audit tool of student practice placements. The tool was designed to meet the needs of a newly established college formed by the merger of three independent nursing and midwifery schools, each with their own clinical auditing strategies. The article outlines the significance of this work, in particular in relation to the production of competent practitioners within the framework of Project 2000 courses.

Education, Nursing↗