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Biomedical subjects

F Gibson

Publications and source records attributed to F Gibson.

158 records · Page 9Linked to original sources
PubMed1966

The role of shikimic acid in the biosynthesis of vitamin K2.

1. Shikimic acid was shown to be a precursor of vitamin K(2) (MK-8) in Escherichia coli. 2. The benzene ring of the naphthaquinone arises from shikimic acid. 3. The methyl group of methionine is incorporated into vitamin K(2). 4. A scheme relating the biosynthesis of vitamin K(2) and ubiquinone to the general pathway of aromatic biosynthesis is proposed.

Acetates↗
PubMedDate not supplied

A systematic review of worldwide cancer nursing research: 1994 to 2003.

The aim of this study was to assess the cancer nursing research papers published in the past decade; identify their characteristics in terms of country of origin, participants, settings, diagnostic foci, and methodologic choices; and evaluate their quality. A systematic review was carried out of all published papers in the Cumulative Index of Nursing and Allied Health Literature between the years 1994 and 2003, using the keywords "cancer," "nursing," and "research." A total of 619 papers met inclusion criteria and were evaluated by 5 researchers. Almost half the papers were derived from the United States (49.1%), followed by the UK, Sweden, Canada, and Australia. In more than half of the published papers (52.2%), health professionals (mostly nurses) were the studies' participants. Also, much of the published research used patients with mixed diagnosis, or patients with breast or hematologic cancers. Two-thirds of the studies were quantitative, whereas most studies were descriptive in nature. The quality of both quantitative and qualitative studies was low, with only a small percentage meeting the highest quality criteria. Studies reporting funding and those published in journals with an impact factor showed a higher quality score than those not reporting funding or not published in journals with an impact factor. Cancer nursing research is still in a developmental stage, although it has made a considerable contribution to the evidence base of the discipline. A number of issues need to be tackled before we improve our output, such as organizational or workforce issues, infrastructure support, funding, and methodologic challenges.

Humans↗
PubMedDate not supplied

Strabismus measurements using the alternating and simultaneous prism cover tests: a comparative study.

PURPOSE: To determine the most accurate method of strabismus measurement in patients with constant manifest esotropia. METHODS: Patients underwent routine cover test assessment with the cover-uncover test and the alternating cover test with any increase in the angle of deviation being noted between the two methods. The simultaneous and alternating prism cover test was then performed to see if a qualitative increase in angle deviation was represented by a quantitative measurement. Patients also were assessed for the presence of binocular vision in free space using Bagolini striated lenses and motor fusion responses to base out prisms. RESULTS: There was a significant difference between the alternating and simultaneous prism cover test measurements for all patients (mean difference for near fixation: 4.72 prism diopters [delta]; 95% confidence interval [CI], 1.68-7.75 delta; df=51; P<.001). For patients who showed a qualitative change in angle based on observational judgement using the cover tests, the mean difference in angle measured by simultaneous and alternating prism cover test for near fixation was 7.42 delta (95% CI, 5.75-10.30 delta; df=25; P<.001). CONCLUSION: To obtain an accurate interpretation of the size of manifest esotropia, the angle of deviation needs to be measured by the simultaneous and alternating prism cover test when an observable difference is noted on the cover test. The presence of a latent component to a manifest deviation should prompt the investigation of binocular reflexes even if the manifest angle is too large to be commensurate with binocular vision.

Adolescent↗