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F Giménez

Publications and source records attributed to F Giménez.

16 recordsLinked to original sources
PubMed2000

Follow-up of transmission of hepatitis C to babies of human immunodeficiency virus-negative women: the role of breast-feeding in transmission.

BACKGROUND: The studies on hepatitis C virus (HCV) vertical transmission, the effect of potential risk factors and the role of breast-feeding have reported conflicting results. PATIENTS AND METHODS: Seventy-three infants of 63 anti-HCV-positive and anti-HIV-negative mothers were studied from 1993 to 1999 in the south of Spain. The mean period of follow-up in children was 29.2 +/- 19 months (range, 8 to 76 months); 6 (8%) children were lost to follow-up. Breast milk was studied for HCV-RNA in 68 samples of 35 mothers. RESULTS: Alanine aminotransferase was high in 19 (26%) and HCV-RNA was positive in 46 (63%) pregnant woman. Breast milk HCV-RNA was negative in nonviremic mothers and positive in 20% of the viremic mothers. The overall rate of vertical HCV transmission was 11.9% (n = 8) (95% confidence interval, 6 to 23%) if HCV-RNA was positive one or more times, but only 1.5% (n = 1) (95% confidence interval, 0.1 to 9%) if HCV-RNA was permanently positive. Seven HCV-infected children did not develop antibodies to HCV, and they had a spontaneous clearance of the virus. A 10-month-old baby was HCV-RNA-positive from birth to the end of the follow-up. The genotype in each of the infants was consistent with that of their mother. The rate of HCV transmission was higher for infants of mothers with higher HCV viremia (P < 0.01) and also for infants whose mothers were HCV-RNA-positive in breast milk (P < 0.05). There were no statistically significant differences between other risk factors. CONCLUSION: The presence of transitory viremia without seroconversion indicates that the vertical transmission of HCV is not important. This could be related to the viral charge and ingestion of milk of HCV-RNA-positive mothers. However, to advise avoidance of maternal breast feeding, it would be necessary to conduct larger studies.

Adult↗
PubMed1998

[Laparoscopic feeding gastrostomy: an alternative to the nasogastric tube].

Dysphagia is common in head and neck cancer and feeding becomes difficult. Nasogastric tubes cannot by placed in some patients and are poorly tolerated in others. However, endoscopic laparotomy techniques have advanced to a point in which they allow feeding gastrostomies to be used, which are non-aggressive, well-tolerated and a satisfactory alternative for patients with contraindications for upper endoscopy.

Deglutition Disorders↗
PubMed1998

Epidemiology and prevalence of seropositivity for hepatitis C virus in pregnant women in Granada.

OBJECTIVES: To study personal and familial antecedents of risk and prevalence of infection by HCV in pregnant women in the south area of Granada. PATIENTS AND METHODS: We included in the study 3003 pregnant women of the south area of Granada during the period from January 1993 to December 1995. Anti-HCV was detected in the third trimester of pregnancy by second and third generation ELISA, and positive results were confirmed by RIBA 3. We also determined HCV-RNA and genotype. Finally, we analyzed ALT levels in 1171 (39%) pregnant women. We carried out an epidemiological survey of all pregnant women, which included the following personal antecedents: transfusion, intravenous drug use, liver diseases, risk profession and sexually transmitted diseases. We studied the same antecedents in the parents, husbands and other relatives. RESULTS: Prevalence of anti-HCV was 0.63% (19 cases) with ELISA and 0.53% with RIBA. HCV-RNA was positive in 14 (74%) genotype 1b (57%) being the most frequent. ALT was increased in 52 (4.4%) pregnant women, 7 (13.5%) of whom were anti-HCV positive, versus 12 women (1%) in the normal ALT group (p < 0.001). In the epidemiological study we observed statistically significant differences in: a) housing characteristics [2125 (71%) anti-HCV negative pregnant women living in occupant-owned housing versus 7 (36%) in anti-HCV-positive group, p < 0.001]; b) personal antecedents of transfusion, chronic or acute hepatitis, or intravenous drug use (p < 0.001) (these factors were confirmed in the multivariable analysis), and c) familial antecedents of the husband (p < 0.05). CONCLUSIONS: In this study we demonstrated that 0.53% of the pregnant women were infected by HCV; most of them were HCV-RNA positive and was genotype 1b was the most frequent. The risk factors most frequently associated with infection were antecedents of transfusion, intravenous drug use and acute or chronic hepatitis.

Female↗
PubMed1994

[Tuberculosis of the pharynx].

Report of two cases of pharyngeal tuberculosis, both patients showing clinical lesions consistent with tonsillar neoplasia. Comments remarking some features regarding its pathogenesis, considerations on the value of diagnostic tests, particularly the baciloscopy, Mantoux-test, and histology, as well as therapeutics considerations.

Adult↗
PubMed1994

[Tonsillar hirudiniasis. Case report].

Report on a tonsillar parasitosis in a 5-year-old child living in the countryside from leeches of Hirudinea. He consulted because a feeling of foreing body in the throat and spitting of blood, since a fortnight. The AA. remark the low incidence of those cases in our environment.

Animals↗
PubMed1993

The prognostic value of mucociliary clearance in predicting success in tympanoplasty.

Mucociliary and equipressive eustachian tube functions have been studied, using saccharin solution (five per cent sodium saccharinate) and tubal manometry respectively, in 58 ears with chronic disease undergoing tympanoplasty. The position of the perforation site determines the results as the poorest results are obtained from the posterior ones, positive cases (47 per cent) and mean transport time (37.7 minutes), compared to the greater percentage of positive cases (86 per cent) and mean transport time (22.2 minutes) for anterior perforations. When both parameters are analysed together there is a direct relationship between normal equipressive function and normal mucociliary transport time and between negative transport time and tubal blocking. Significant difference in transport times have been found for the anterior and posterior perforations being shorter for the anterior ones. When surgical outcome is correlated with mucociliary transport, the normal transport time percentage is seen to be considerably higher in the success group (50 per cent) than in the failure group (22 per cent).

Adolescent↗
PubMed1990

[Olfaction in laryngectomized patients: effect of the phonatory prosthesis].

We have studied olfaction in 20 laryngectomies, only 10 of which were supplied with phonatory prosthesis. We conclude that patients without prosthesis show a higher threshold for perception of pure olfactory stimulants, whereas in those provided with the prosthesis the pure olfactory threshold remains within normal values.

Adult↗
PubMed1989

[Cancer of the testis: risk factors and evolution of mortality in Spain (1951-1983)].

Herein we report the results of a study on the mortality trends of testicular cancer in Spain from 1951-1983. The study showed that following a long period of increased mortality, overall mortality rates for all age groups have dropped in recent years. However, the mortality rate has increased for the young and middle-aged males and has dropped for the older age groups. A similar finding has been observed for other countries such as the United States. We have attempted to interpret these changes based on the risk factors for this type of cancer.

Age Factors↗
PubMedDate not supplied

[Diagnostic imaging of inflammatory bowel disease].

This article considers the possibilities of different image acquisition techniques in the study of inflammatory bowel disease, with special emphasis on the roles of tomodensitometry and magnetic resonance imaging. Although these techniques are not superior to barium follow through studies or conventional enteroclysis at depicting the mucosa in detail, they are very useful in the evaluation of the characteristics of the walls of the bowel loops and in the detection of possible extraluminal complications, such as abscesses, adenopathies, and mesenteric involvement. Magnetic resonance shows great potential for the study of the small bowel and is likely to play an important role in the study of inflammatory bowel disease in the near future. This recurring disease affects young patients with long life expectancies in whom exposure to ionizing radiation needs to be minimized. We explain the radiologic findings through a physiopathologic approach to the sequence of events (aphthoid ulcers, fissuring and penetrating ulcerations, formation of fistulous tracts, abscesses, mesenteric involvement) that give rise to them. We propose an objective classification based on the imaging findings that is useful for therapeutic decision making, and we describe the important role of the radiologist in the follow-up as well as in the diagnosis of this entity.

Colitis, Ulcerative↗
PubMedDate not supplied

[Long-term (5 years) comparative study of patients with phonatory prosthesis: myotomy versus non-myotomy].

A group of 122 patients that underwent a total laryngectomy and phonatory prosthesis surgery are evaluated after five years follow up. We compared three different techniques. 1) Herrmann technique; 2) total laryngectomy and inferior pharyngeal constrictor myotomy, and 3) classic total laryngectomy. Failures and complications are analyzed. A functional evaluation of the patients is made by means of oesophageal manometry and pharyngo-oesopyhageal isotopic transport. Voice quality is assessed in each group. As a conclusion inferior pharyngeal constrictor myotomy is very positively evaluated.

Aged↗
PubMedDate not supplied

[Laryngeal paraganglioma: a case report].

A case of laryngeal paraganglioma in a 25-year-old female is reported. The site of the tumor was the left aryepiglotic fold and ventricular band. The diagnosis was made by histology and immunohistochemistry medial thyrotomy was performed in order to remove a bilateral carotid paraganglioma. We analyzed 76 cases reported in the world literature, clinical, histological, prognostic, and therapeutic factors in laryngeal paraglioma.

Adult↗
PubMedDate not supplied

[Cervical synovial sarcoma: a case report].

Synovial sarcomas of the head and neck are rare, fewer than 80 cases having been reported in the literature. A synovial sarcoma of cervical soft tissues presented as a lateral mass in a 51-year-old male and was treated by cervical dissection and radiotherapy. After 24 months the patient is recurrence-free. The histology and origin of synovial sarcomas is discussed.

Humans↗