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Biomedical subjects

F Girardin

Publications and source records attributed to F Girardin.

5 recordsLinked to original sources
PubMed2005

[Antihypertensive therapy and drug-drug interactions].

Adverse drug reactions (ADR) have increasing clinical implications and are a permanent challenge for general practitioners. Data suggest that ADR cause 3 to 18% of all hospital admissions with potentially serious consequences. Polymedication, female sex, multiple pathologies with age-related changes are predisposing factors. Antihypertensive drugs with a low bioavailability, a high protein binding capacity and specific elimination pathways are particularly prone to pharmacokinetic interactions. ACE-inhibitors, atenolol, moxonidine and diuretics have few pharmacokinetic interactions. Calcium channel blockers and beta-blockers are associated with an increased risk of pharmacokinetic drug-drug interactions. Diltiazem and verapamil are particularly prone to interactions, as they strongly inhibit the elimination of drugs undergoing the CYP3A4 and P-glycoprotein pathways.

Antihypertensive Agents↗
PubMed2005

[The selection of a drug in a defined therapeutic class: the case of the HMG-CoA reductase inhibitors].

The HMG-CoA reductase inhibitors have similar therapeutic targets and indications. However, their potential pharmacokinetic drug-drug interaction profile may play a significant role in their safety profile in polymedicated and polymorbid patients and can serve as a selection criterion. If their utility is clearly demonstrated in selected conditions, their safety profile remains of concern. Beside dose-related hepatic and muscular injury, other rare and important adverse drug reactions have been reported after prolonged administration such as polyneuropathy, fibrotic interstitial pulmonary disease and lupus-like syndrome. Teratogenicity has also been associated with statin therapy.

Humans↗
PubMed1999

Relationship between corneal temperature and finger temperature.

BACKGROUND: Because the temperature of the body surface depends largely on local blood flow, temperature measurements might provide information on the latter. OBJECTIVE: To evaluate the relationship between corneal temperature and finger temperature. METHODS: Corneal, finger, and body core temperatures were measured in a relatively unselected population of 266 white persons. Excluded were persons taking topical eye medication or with corneal inflammatory signs. Corneal and finger temperatures were measured on 1 randomly selected side of the body by means of a noncontact infrared thermometer. As a measure of body temperature, the tympanic temperature was measured by means of a noncontact infrared ear thermometer. A total of 124 females and 142 males were examined. RESULTS: A correlation analysis in a least squares regression model was highly significant (R = 0.67; P<.001), with corneal temperature as the dependent variable and environmental, tympanic, and finger temperatures and age and sex as predicting variables. All variables contributed significantly to prediction of the corneal temperature. The corrected mean corneal temperature after adjusting for environmental, tympanic, and finger temperatures and for age of participants was 0.16 degrees C higher in male participants (P = .002). CONCLUSIONS: Corneal temperature correlates with finger temperature even after adjusting for environmental and tympanic temperatures and for the age and sex of participants. A possible cause for these findings are some parallelisms in blood-flow regulation in the finger and the eye.

Adolescent↗