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Biomedical subjects

F Girgis

Publications and source records attributed to F Girgis.

6 recordsLinked to original sources
PubMed1995

Detection of cellular and humoral markers (IL-2, IFN-gamma and IgE) in sera of patients with urinary schistosomiasis.

Schistosomiasis continues to be major health problem throughout the developing world. Infection with Schistosoma haematobium is associated with very high morbidity. The work aimed at the determination of role of cellular immune response (IL-2, and IFN-gamma) and specific humoral IgE in protective immunity in human urinary schistosomiasis, as a function of both age and infection intensity including examination of changes in immunoresponsiveness following curative therapy. The study revealed that IL-2,IFN-gamma level were higher in all patients compared to the normal control group and the levels were higher in lightly infected groups than heavily infected ones with no respect to age. IgE levels showed higher values compared to normal individuals and IgE levels were higher in children groups than in adults regardless of the intensity of infection. IL-2, IFN-gamma and IgE levels were higher in patients with mixed S. mansoni and S. haematobium infections than monoinfected patients. Follow up of patients 2 months, 4 months and 12 months after Praziquantel treatment showed that the level of IL-2 and IgE fell back to normal values after 4 months while IFN-gamma remained high, IL-2, IFN-gamma and IgE were raised once more after 12 months.

Adolescent↗
PubMed1989

Histological changes of the esophageal mucosa in bleeding versus non-bleeding varices.

There is considerable controversy as regards the exact cause of bleeding from esophageal varices. This study examined changes in the mucosa of such patients in an effort to understand the underlying mechanisms. Fifty patients were studied, 20 with a history of variceal bleeding and 30 without who served as controls. Endoscopic biopsies were taken from the inter-variceal mucosa within 5 cm from the cardia and were examined histopathologically. The results showed dilated intra-epithelial blood-filled channels within the squamous epithelium and the lamina propria in all bleeders, and in 50% of the non-bleeders. Evidence of esophagitis was also more pronounced in bleeders (50%) than in non-bleeders (23.3%). It is our opinion that esophagitis and the presence of dilated blood-filled channels may play a role in the initiation of variceal bleeding.

Adult↗
PubMed1988

The assessment and management of the failed back, Part II.

Despite adequate surgery a number of patients have a return of back pain and sciatica following operation, the so-called failed back. The results of a prospective study of 101 patients entering an intensive rehabilitation programme for the failed back is described. The programme consists of a team approach to the patient and his problems, using a variety of techniques to produce pain relief. Non-organic pain represents a significant problem in the failed back; 58% of patients were completely or substantially relieved of their pain. Transcutaneous nerve stimulation was found to be the single most useful treatment with exercise second. Non-organic pain was able to be relieved by this programme.

Aged↗