Biomedical subjects

F Giroud

Publications and source records attributed to F Giroud.

22 records · Page 2Linked to original sources

PubMed1979

A double scanning microphotometer for image analysis: hardware, software and biomedical applications.

A new image processing system designed for densitometry and pattern analysis of microscopic specimens is described with special regard to the hardware, the software and the biologic applications. The data acquisition procedure involves the combination between the scanning of the preparation by means of a motorized stage and the scanning of successive fields by a mechanical device. The signal provided by the photomultiplier is converted into digital values which are directed to an on-line computer. The data processing is based on a one-pass computation involving automata theory and therefore it avoids the storage of the image in the computer memory. In so doing, an entire and continuous image of the whole preparation can be processed at the highest magnification of the microscope whatever the size of the analyzed specimen may be. A biologic application of the system is reported and concerns the automatic identification and counting of cells in the various phases of the mitotic cycle.

Animals↗

PubMed1979

[SAMBA : a cytophotometer coupled to a computer for the purpose of the automatic study of cell kinetics and the recognition of cell types].

The system SAMBA has been designed for automatic analysis of biological images, at the cellular or subcellular level. The examination is performed at the maximum resolution power of the microscope. It enables to discriminate by means of a pool of morphological and densitometrical parameters, between cells in the different phases of the cell cycle, or between cells belonging to various types in heterogeneous populations. Other recognition programs are at present beeing in progress, in order to promote the use of SAMBA in other fields of fundamental research and clinical application. Owing to the minicomputer now in use, SAMBA is an autonomous system, capable of beeing routinely used in diagnostic centers.

Bone Marrow Cells↗

PubMed1978

[Automatic recognition of different phases of the cell cycle and automatic count of the cells by means of a computer coupled to a cytophotometer].

Existing relationships between cell cycle phases and chromatin scattering within the nucleus led us to state more precisely our first alogrithm for cell cycle phases recognition. These refundments give evidence for the accuracy and the improving performance of the densitometric and morphologic analysis system used in this study: the "Samba".

Animals↗

PubMedDate not supplied

Optimization of microencapsulation of acrylic adhesives.

The preparation of microcapsules of an acrylic adhesive in a solvent medium with reticulated walls of melamine-formaldehyde was studied. In order to obtain the best experimental conditions for this process, the methodology of factorial design was used. It was found that, among the 11 tested parameters, four had an important effect on the microencapsulation: amount of wall polymer, amount and nature of the copolymer, GANTREZ, and amount of adhesive in the core. The process was optimized using a surface response methodology. A layer of microcapsules deposited on paper gave, after manual breakage, very good adhesive properties.

Acrylates↗