Biomedical subjects
F Grainger
Publications and source records attributed to F Grainger.
The scandal of poor medical research. Sloppy use of literature often to blame.
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A comparison of the currency of secondary information sources in the biochemical literature. II. MEDLINE online and on CD-ROM.
The currency of selected versions of the MEDLINE database on CD-ROM and in online format was studied. The arrival of issues from 72 monthly journals and nine weekly titles during a 3-month period was monitored and their appearance in the various MEDLINE formats were recorded. Availability data for MEDLINE published by the National Library of Medicine were used as a baseline and subsequent distribution delays for the different MEDLINE formats were calculated. The study suggests a delay of approximately 2 weeks for indexing and mounting the MEDLINE file on to host computers for online access. A delay of 6-8 weeks was calculated for the MEDLINE data to be encoded on to compact disk, shipped and posted to the library customer. The currency of the MEDLINE database formats was compared with a weekly current-awareness service, CURRENT CONTENTS ON DISKETTE LIFE SCIENCES (CCOD). The majority of papers were indexed and distributed in CCOD within 10 weeks of publication date. Most papers appeared within 15 weeks in the online MEDLINE format and within 20 weeks in CD-ROM MEDLINE. The primary journal arrived at the library site within 5 weeks in most cases.
A comparison of the currency of secondary information sources in the biomedical literature. I. Weekly current awareness services.
Three biomedical current awareness products which are distributed on floppy disc, were studied over a period of 3 months. They were monitored for the speed with which primary journal issues were indexed, and for the coverage of the journals which were selected for study. Data on issues of 72 monthly journals (38 North American and 34 European) and nine weekly titles (four from North America and five from Europe) were recorded. The time to elapse between publication date and arrival of hard copy in the British libraries and appearance in secondary sources varied enormously. The findings suggest that monthly journal issues appear in the secondary sources on average 6-7 weeks after publication date and weekly journals appear after approximately 4 weeks. Indexing of North American monthly journals is 1 week ahead of European titles in the two products from the US, but the European service indexed European publications sooner. One product, Current Contents on Diskette, contained all issues included in the 3-month period covered by the study, but Reference Update omitted 9.1% of the issues and Medical Science Weekly 1.6%, including leading biomedical journals.
Microtubular number in the tractus hypophyseus of newborn normal rats and newborn rats with congenital diabetes insipidus.
Evidence has already been adduced suggesting that an increase in microtubular number occurs in the tractus hypophyseus of rats stressed by the administration of hypertonic saline, and of rats with congenital diabetes insipidus (CDI). Since the tractus hypophyseus in these animals shows high secretory activity, it seems likely that the microtubular increase reflects the participation of microtubules in axoplasmic transport. To exclude, however, a congenital microtubular abnormality in CDI, affected newborn rats were examined. In these, the microtubular number was normal, thus suggesting that the increase in microtubular number seen in adult animals was not a congenital morphological abnormality. However, by 4 days of age there was a slight but statistically significant increase in microtubular number in affected rats, a change probably attributable to increased secretory activity.
Correlation between microtubular number and transport activity of hypothalamo-neurohypophyseal secretory neurons.
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Factors affecting the variability of kinetic enzyme assays.
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Association of glial cells with the terminal parts of neurite bundles extending from chick spinal cord in vitro.
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Scanning electron microscopic observations of chick embryo fibroblasts in vitro, with particular reference to the movement of cells under others.
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Mitochondrial extensions associated with microtubules in outgrowing processes from chick spinal cord in vitro.
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An electron-microscopic study of the early outgrowth from chick spinal cord in vitro.
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