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Biomedical subjects

F Grandillo

Publications and source records attributed to F Grandillo.

At least 19 recordsLinked to original sources
PubMed1984

[Effects of low O2 tension on platelet aggregation].

Several studies in animals suggest a link between haemocoagulative patterns and blood gas changes. Furthermore platelet functions seem to be affected by O2 concentrations. In the present study we have evaluated "in vitro" the effect of low PO2 concentrations on platelet aggregation in man. In 15 normal subjects (mean age 32 +/- 5) platelet aggregation ADP (end conc. 1,25 microM) and collagen induced 2 micrograms/Ml) was determined before and after exposition to low PO2 concentrations (O2 conc. 5,04%). The results show that low PO2 concentrations determine a significant increase (P less than 0,001) of platelet aggregation as compared to controls. Although the mechanism of the direct influence of PO2 concentrations upon human platelet is unclear, this finding suggest new therapeutic approaches in chronic lung obstructive diseases.

Adenosine Diphosphate↗
PubMed1984

P50 values determined by tonometry and by simplified techniques.

Actual determination of the position of the oxygen hemoglobin dissociation curve (P50) was compared to three methods of estimating P50 in 39 patients with various diseases. There was a significant correlation between determined and estimated P50 values (P less than 0,001) for each of the methods studied. The data suggest that calculating P50 is reliable and may replace the need for actual measurement.

Adult↗
PubMed1983

[Effect of pentoxifylline on the dissociation curve of oxyhemoglobin].

In 9 subjects with peripheral vascular insufficiencies the AA. have studied the behaviour of the oxyhaemoglobin dissociation curve before and after pentoxyphilline infusion. After this drug no variations were observed as it regards MCHC, 2-3-DPG and so on; however a positive correlation was found between 2-3-DPG and the Hill number. These results suggest that 2-3-DPG may influence the Hill number (which is the expression of the gradient of the oxyhaemoglobin dissociation curve) and therefore may interfere with O2 transport.

Aged↗
PubMed1980

[Thromboelastographic patterns in patients suffering from chronic obstructive lung disease after hyperventilation].

In an our previous study we studied the influence of O2 therapy administration on the thromboelastographic pattern of patients suffering from chronic obstructive lung disease. We showed that basal hypocoagulability of our patients became normal after O2 administration. In this study we refer the thromboelastographic pattern observed in patients suffering from the same disease before and after hyperventilation. We don't find any changes about total coagulability either in patients or in healthy subjects after hyperventilation. Therefore we suggest that the absence of any changes is due to PCO2 and pH variations that occur at the same time of PO2 modification during hyperventilation; PCO2 and pH variations may influence the haemoglobin oxygen affinity and annul the effect of the increase PO2 on the tissue oxygenation. We suppose that the increase of patients suffering from chronic obstructive lung disease, is due to decreased fibrinolysis or to increased production of prostacycline induced by hyperventilation.

Adult↗
PubMed1980

[PO2 and PCO2 after nifedipine administered by the sublingual route in hypertensive patients (author's transl)].

The Authors have examined the PO2 and PCO2 of peripheral arterial blood in 10 hypertensive subjects before and after 20 mg of nifedipine administered by sublingual route. A PaO2 decrease and a light increase of PaCO2 were observed; this pattern, if considered together with the increase of CO2 and the decrease of pulmonary resistance, may be attributed to a greater perfusion of those districts having a low V/Q ratio.

Administration, Oral↗