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Biomedical subjects

F Guerrin

Publications and source records attributed to F Guerrin.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

[Acute hypercapnia and bile. Experimental studies in the rat (author's transl)].

The bile acid-base parameters are analyzed in 42 male Wistar rats under pentobarbital anaesthesia, in normal conditions of blood acid-base equilibrium. The reproducibility of the results is emphasized. In acute hypercapnia (FICO2 : 0.12 for 15 min) without hypoxia, and for the same increase in PCO2, and pH variation is lesser in bile than in blood, thus showing an high buffer capacity. In vitro and in vivo comparative studies show that bile buffer capacity is about five times higher in vivo, independently of a possible increase in choleresis. Comparative studies of bile-acid-base equilibrium are effected during perfusions of dehydrocholate, sodium taurocholate, secretin and acetazolamide. Sodium and chlorine remain stable during hypercapnia both in blood and in bile ; potassium concentration is increased in the two media. To explain these results, the role of the liver is still to specify.

Acetazolamide↗
PubMedDate not supplied

[Respiratory parameters in pneumoconiotic miners in the north French coal district (author's transl)].

The authors examine the respiratory tests performed during a two years-period in 676 pneumoconiotic miners. Spirography was normal in 8% of the cases; a mixed ventilatory impairment, with an obstructive prevalence of variable extent, was present in 2/3 of the cases. Pharmacodynamic tests in 353 subjects showed a frequent non-specific bronchial sensitivity (34.2% of the whole group). Hypoxaemia (PaO2 below 75 mmHg) with normo- or hypocapnia was observed in 379 patients; hypercapnia was relatively uncommon (9.9%) and occurred mainly in bronchitic patients. The breath holding CO lung transfer test was very often disturbed, as the diffusing capacity (DLCO) was below the predicted value in about 80% of the population. Radiofunctional comparisons were carried out in an homogeneous group of 212 subjects. The data clearly demonstrate that functional abnormalities were not exclusively seen in extensive radiological forms. As far as it goes beyond a simple ventilatory study, the measurement of the breath holding lung transfer factor for CO has proved to be a valuable element in the functional statement of anthracosilicosis. The polymorphism of the pulmonary repercussions of dust exposure explains individual differences between the results of the main investigations, and this emphasizes the need for a series of diversified tests.

Adult↗