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Biomedical subjects

F Guzzardi

Publications and source records attributed to F Guzzardi.

3 recordsLinked to original sources

ESWL: Comparing two analgesic techniques. Our experience.

OBJECTIVE: We compared the effects of intramuscular analgesia versus intramuscular analgesia associated with topical application of Luan (gel containing lidocaine 1%) on the efficacy of extracorporeal shockwave lithotripsy (ESWL). MATERIAL AND METHODS: From January 2001 to November 2002, 300 patients (mean age 46) were treated for kidney or upper ureteral radiopaque stones with ESWL, using a Dornier Compact Delta magneto lithotripter. The patients were divided into two groups: group A, 180 patients, received intramuscular analgesia with Ketorolac 30 mg, Tramadolo 100 mg and, during treatment, intravenous betametasone 4 mg. Group B, 120 patients, received the same pharmacological treatment associated with topical application of Luan. RESULTS: At 3 months, the stone-free rate in group A was 61% compared with 79% in group B. The energy of treatment was less than 13 kV in group A and less than 15 kV in group B. CONCLUSIONS: For ESWL treatment of kidney stones of 20 mm or less and ureteral stones of 15 mm or less, we suggest local analgesia with topical Luan and intramuscular analgesia. This approach increases the success rate of ESWL and reduces the discomfort associated with treatment.

Administration, Topical↗

Acute effects of salmon calcitonin in man include stimulation of the renin-angiotensin-aldosterone system.

The present double-blind placebo-controlled cross-over study was designed to evaluate the renin-angiotensin-aldosterone system behavior after a short-term infusion of a pharmacological dose (100 MRC U) of salmon calcitonin. Overall, a significant increase in plasma renin activity, aldosterone and serum angiotensin-converting enzyme was seen throughout. This effect may be, at least in part, due to the renal loss in sodium and calcium ions, while the increased kaliuresis could be interpreted as a consequence of the stimulation of aldosterone release.

Adult↗