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Biomedical subjects

F Györkey

Publications and source records attributed to F Györkey.

At least 19 recordsLinked to original sources
PubMed1983

Ionic milieu and volume adjustments in detergent-extracted thymic nuclei.

Detergent-extracted isolated thymic lymphocyte nuclei were incubated in buffers containing 3 mM Ca++ and Mg++ and varying concentrations of Na+ and K+. Nuclei in 15 mM K+, 15 mM Na+ had a smaller size, smaller interchromatin spaces, and less packed chromatin than nuclei in the absence of these ions, but their water content relative to dry mass was not significantly different. NMR relaxation properties of water protons in these different nuclei were different, and nuclei in 15 mM K+, 15 mM Na+ contained twice as much K and Na as in the buffer solution. These findings indicate that the hydration of chromatin bodies and the size of the interchromatin spaces are sensitive to the free monovalent ion concentrations. When isolated nuclei were exposed to solutions containing 150 mM total concentration of K + Na, the nucleoplasm became disrupted and the hydration index was greater. The results are discussed in regard to possible mechanisms of nuclear volume control in cells.

Animals↗
PubMed1979

Nephrotic syndrome in anti-GBM antibody mediated glomerulonephritis.

Glomerulonephritis induced by antibodies to the glomerular basement membrane is a well recognized cause of renal disease and is responsible for 5% to 15% of all glomerular disease. The patients usually present with an acute nephritic syndrome followed by rapidly progressive renal failure. We report two patients who presented with the nephrotic syndrome and anti-GBM glomerulonephritis, and who exhibited differing clinical courses not characteristic of "rapidly progressive glomerulonephritis" or Goodpasture's syndrome.

Adult↗
PubMed1979

[Nuclear antigens in tumorous and non-tumorous tissues].

The observations suggest that the cells of the human malignomas contain such protein or proteins which keep their specific antigenic characteristics even under isolation techniques. These characteristics have been directly due to the nucleus of the malignant cell, and had remained also under the cell-culture process. The nuclear antigen and specific antibody technique described in this paper seem to be suitable as an immunofluorescent method in the immunodiagnostics of the human tumors, furthermore provide valuable data in the clarification of the problem of human tumors.

Antigens, Neoplasm↗
PubMed1979

Membranous nephropathy with epithelial crescents in a patient with pulmonary sarcoidosis.

Renal failure in patients with pulmonary or extrapulmonary sarcoidosis has been attributed to interstitial disease. Reports of cases of primary glomerular abnormality with renal failure in patients with sarcoidosis are rare. We describe a patient with pulmonary sarcoidosis and renal failure due to membranous nephropathy with epithelial crescents. A review of primary glomerular involvement in patients with sarcoidosis and the association of immune complexes in the pathogenesis of the two diseases is discussed.

Basement Membrane↗
PubMed1976

Myeloma-like lesions of the kidney. Occurrence in a case of acinic cell adenocarcinoma of the pancreas.

A 54-year-old man with acinic cell adenocarcinoma of the pancreas died of oliguric renal failure associated with myeloma-like renal lesions. Electron microscopical study of the tumor cells disclosed rich rough-surfaced endoplasmic reticulum and membrane-bound secretory granules, which indicated active protein synthesis and suggested that abnormal proteins produced by the tumor cells were the underlying cause of the renal lesions. Rapid deterioration of renal function ensued after intravenous pyelography, as is usual in the syndrome of myeloma-like lesions of the kidneys. This case presents further evidence for the occurrence of "myeloma kidney" in association with tumors other than plasma cell myeloma.

Carcinoma↗
PubMed1975

Nephropathy in patients with drug addiction. Evolution of pathological and clinical features.

The course of the nephropathy in patients with drug addiction has been studied in six subjects. The nephrotic syndrome with the presenting feature in all, with two progressing to terminal renal failure in less than a year. Serial percutaneous renal biopsies revealed the basic lesion to be a mild non-specific increase in PAS-positive material in the mesangial areas. This was more marked in the two patients with renal failure who, in addition, had segmental PAS-positive material in the glomerular capillary loops, focal tubular dilatation and atrophy, interstitial edema and mononuclear cell infiltration. Immunofluorescent staining revealed lumpy granular staining. IgG, present at the onset of the nephrotic syndrome, subsided as the first two patients developed renal failure, while beta1C and IgM, negative at the onset, became positive. Electron microscopy revealed focal basement membrane thickening and deposition of homogenous, finely granular electron-dense material predominantly in the mesangial areas. Our findings indicate that renal damage secondary to immune-complex deposits develops in the addict. The presence of interstitial swelling, mononuclear infiltration and tubular dilatation signals rapid deterioration of renal function and a grave prognosis, while their absence indicates a more prolonged indolent course.

Antigen-Antibody Complex↗
PubMed1975

Growth of permanent lymphoid cell cultures from human source: tenth anniversary.

The authors developed 52 permanent lymphoid cell cultures from various human sources, mainly from neoplastic lymphoproliferative disease. These cultures are reviewed against the background of similar cultures obtained in several other laboratories. The peculiar features of these cultures are: 1) the phenomenon of lymphoblastoid transformation; 2) the production of both globulins and mediators of delayed hypersensitivity; 3) the presence of herpes type virus as related to etiology or autoimmunity; and 4) cytotoxicity and other assays for the demonstration of tumor-specific antigens.

Animals↗