PubMed HealthSearch

Biomedical subjects

F H Attix

Publications and source records attributed to F H Attix.

At least 19 recordsLinked to original sources

A comparison of methods for calibrating parallel-plate chambers/.

All dosimetry protocols for calibrating the output of electron beams recommend the use of parallel-plate ionization chambers, but the method of determining their value of Ngas is a matter of concern. The AAPM Protocol (TG 21) recommends a direct comparison with a calibrated cylindrical chamber in phantom at dmax with the highest available electron energy beam. This must be done by the user. Since all calibration laboratories traditionally use 60Co for megavoltage chamber calibrations, two alternate procedures based on exposures in-air, or in-phantom, have been proposed. All methods use correction factors in the data reduction. To verify the consistency of the three methods, we have measured Ngas using each of these techniques for six of the most commonly used and commercially-available parallel-plate ionization chambers. The paired cylindrical and parallel-plate ionization chambers, and phantom materials/buildup caps were matched to the wall composition of the plane chambers, as recommended in TG 39. A 22 MeV electron beam was used for the electron irradiations. The ionization chambers were then taken to an Accredited Dosimetry Calibration Laboratory (ADCL), where 60Co calibrations were performed. The results demonstrate that, by using the appropriate correction factors for the chambers described in this work, all three methods yield values for Ngas that are within 1% of each other.

Biophysical Phenomena

The calibration and use of plane-parallel ionization chambers for dosimetry of electron beams: an extension of the 1983 AAPM protocol report of AAPM Radiation Therapy Committee Task Group No. 39.

This report is an extension of the 1983 AAPM protocol, popularly known as the TG-21 Protocol. It deals with the calibration of plane-parallel ionization chambers and their use in calibrating therapy electron beams. A hierarchy of methods is presented. The first is to calibrate the plane-parallel chamber in a high energy electron beam against a cylindrical chamber which has an Ncylgas value that has been obtained from a NIST traceable 60Co beam calibration. The second method, which is recommended for implementation by the ADCLs is an in-air calibration against a NIST-traceable calibrated cylindrical chamber in a Cobalt-60 beam to obtain a plane-parallel-chamber calibration factor in terms of exposure or air kerma. The third method places the two chambers in a phantom in a Cobalt-60 beam, and leads to an Nppgas value for the plane-parallel chamber. This report also gives Nppgas/NxAion)pp and Nppgas/(NkAion)pp values for five commonly used commercially available plane-parallel chambers: the Capintec PS-033, the Exradin P-11, the Holt, the NACP and the PTW-Markus. The calculation of these Ngas ratios introduces a Kcomp factor which is also calculated for the five parallel plate chambers. The use of the plane-parallel chambers follows the 1983 AAPM protocol for absorbed dose calibrations of electrons, except that new energy-dependent Prepl values are given for the Capintec PS-033 and PTW-Markus chambers consistent with the consensus of reports in the literature. For all the chambers, however, Prepl is unity for 20 MeV electrons. This report does not address the issue of the use of plane-parallel chambers in calibrating photon beams.

Cobalt Radioisotopes

A new re-entrant ionization chamber for the calibration of iridium-192 high dose rate sources.

A re-entrant (well-type) ionization chamber has been designed and fabricated at the University of Wisconsin for use with iridium-192 high dose-rate (HDR) remote after-loading brachytherapy devices. The chamber was designed to provide an ionization current of about 10(-8) ampere with a nominal 10 curie iridium-192 source. A narrow opening is provided into the sensitive volume of the chamber to insert a Nucletron MicroSelectron catheter, or catheters with similar diameters from other HDR manufacturers. The chamber exhibits a flat response (+/- 0.1%) for any source position within +/-4 mm of the chamber center. A 300 volt chamber bias yields a 99.96% ion collection efficiency. The chamber is capable of being calibrated directly with an iridium-192 source which has in turn been calibrated with thimble-type ion chambers. Reproducibility for readings in the current mode for 10 consecutive insertions of the MicroSelectron iridium-192 HDR source is within 0.02% or less. Two thimble chambers calibrated by the U.S. National Institute of Standards and Technology provide calibration traceability of iridium-192 HDR sources and re-entrant chambers to a primary national standards laboratory. Results of activity measurements of 6 commercial iridium-192 HDR sources are reported.

Calibration

Water-equivalent plastic scintillation detectors for high-energy beam dosimetry: I. Physical characteristics and theoretical consideration.

A minimally perturbing plastic scintillation detector has been developed for the dosimetry of high-energy beams in radiotherapy. The detector system consists of two identical parallel sets of radiation-resistant optical fibre bundles, each connected to independent photomultiplier tubes (PMTs). One fibre bundle is connected to a miniature water equivalent plastic scintillator and so scintillation as well as Cerenkov light generated in the fibres is detected at its PMT. The other 'background' bundle is not connected to the scintillator and so only Cerenkov light is detected by its PMT. The background signal is subtracted to yield only the signal from the scintillator. The water-equivalence of plastic scintillation detectors is studied for photon and electron beams in the radiotherapy range. Application of Burlin cavity theory shows that the energy dependence of such detectors is expected to be better than the commonly used systems (ionization chambers, LiF thermoluminescent dosimeters, film and Si diodes). It is also shown that they are not affected by temperature variations and exhibit much less radiation damage than either photon or electron diode detectors.

Fiber Optic Technology

Water-equivalent plastic scintillation detectors for high-energy beam dosimetry: II. Properties and measurements.

The properties of a new scintillation detector system for use in dosimetry of high-energy beams in radiotherapy have been measured. The most important properties of these detectors are their hgh spatial resolution and their nearly water-equivalence. Measurements have shown that they have excellent reproducibility and stability, and a linear response versus dose-rate. It is also shown that they have better spatial resolution than ionization chambers and have much less energy or depth dependence in electron fields due to the removal of the influence of the polarization effect. Dose distributions in water, using miniature plastic scintillation detectors, have been measured for different high-energy photon and electron beams.

Fiber Optic Technology

Experimental derivation of beta for high-energy photons.

The absorbed dose in a medium for a given beam of megavoltage photons is related to the collision kerma by the energy dependent parameter beta. Some theoretical methods of estimating and calculating beta have been proposed in the past. The majority of the methods take into account only Compton interactions, with just one method taking into account the beam spectrum, coherent and incoherent scattering and pair production effects. Experimentally measured data, on the other hand, implicitly include appropriate contributions of all these processes. Experimentally derived beta values are tabulated and the rationale for their measurement is discussed. The beta value for a low-Z ion chamber calibration in free space with a 60Co gamma-ray beam is 1.002. The dependence of beta on several factors such as energy, field size, phantom material and depth has been studied.

Dose-Response Relationship, Radiation

Energy imparted, energy transferred and net energy transferred.

The ICRU-defined non-stochastic quantity absorbed dose is related to the stochastic quantity energy imparted. In this paper the corresponding stochastic quantities energy transferred and net energy transferred are defined as precursors for kerma and collision kerma, respectively. This forms a rational fundamental framework for radiation dosimetry which facilitates its teaching and understanding.

Energy Transfer

Comparison of Burlin cavity theory with LiF TLD measurements for cobalt-60 gamma rays.

Cobalt-60 gamma-ray absorbed dose measurements were carried out using LiF thermoluminescent (TL) dosemeters to obtain additional insight into cavity theory as applied to dosemeters of a size intermediate relative to the range of secondary electrons. Stacks of dosemeters (0.4 mm x 3 mm x 3 mm, hot-pressed LiF TLD-100) were surrounded by homogeneous LiF, polystyrene, aluminium, copper or lead. The absorbed dose in the stack (0.1 to 0.7 g cm-2 thick) was derived from TL readings of the individual dosemeters, and was compared with calculations based on the Burlin cavity theory. A relatively strong asymmetry in the experimental absorbed-dose distribution was found between the front, rear and middle dosemeters of the stack, especially when lead was the surrounding medium. Cavity theory shows good agreement with the experimental results obtained in polystyrene, while theory tends to overestimate the dose in the LiF dosemeters enclosed in Al, Cu, and Pb. The general trend predicted by the Burlin theory is somewhat steeper relative to cavity size than that observed experimentally. The theory was modified to make it more applicable to the dose at the centre of the stack. For lead this clearly agreed more closely with experimental results than did the conventional theory.

Cobalt Radioisotopes

The use of 10B to enhance the tumour dose in fast-neutron therapy.

Incorporation of 10B in tumours treated by fast-neutron therapy would increase the tumour dose via the reaction 10B(n, alpha)7Li which occurs with partially thermalised neutrons. The extent of the dose enhancement was measured for neutron beams with median energies of 2.4, 3.3, 7.0 and 9.0 MeV by two techniques: with a BF3 proportional counter in three beams and activation of 23Na in the fourth. The results obtained with the two techniques are in good agreement. The magnitude of the dose enhancement depends upon the depth, field size and neutron beam energy. The dose enhancement at a depth of 8 cm varied from 0.32% with the lowest-energy beam to 0.07% with the highest-energy beam for each microgram of 10B uptake per gram of tissue. The products of the reaction in 10B would, however, have an RBE about twice that of the fast-neutron dose in the absence of boron. The method may be useful if drugs providing adequate uptake of 10B can be synthesised.

Beryllium

Attenuation measurements of a fast neutron radiotherapy beam.

Attenuation measurements have been made for pressed wood, steel and lead in the neutron beam generated by 35 MeV deuterons on a thick Be target, using narrow-beam, semibroad-beam and broad-beam geometries. In addition, the measurements were extended to the neutron beams from 25 and 15 MeV D+ on Be, for semibroad-beam geometry only. A tissue-equivalent plastic ionization chamber was used as the detector; hence the measured parameter approximated the total (n + gamma) dose in tissue. After correcting for radiation scattering around the absorbers, the remaining curves were nearly exponential in most cases, and a build-up factor could be employed to describe the varying degree of scattered radiation dose as a function of absorber thickness and geometry. The results given should be applicable in designing primary-beam shields and collimators, as well as providing a useful basis for extending calculations to other geometries through Monte Carlo techniques.

Deuterium

Stripping-theory analysis of thick-target neutron production for D + Be.

The Serber theory for deuteron stripping is employed to predict the shape of the neutron energy spectrum produced by 35 MeV deuterons (D+) on a thick beryllium target. In particular, the observation that the maximum of the neutron energy spectrum (at 0degrees relative to the deuteron beam direction) occurs at approximately 0-4Ed, where Ed is the incident deuteron energy, is explained reasonably well by the calculations. The explanation stems mainly from the fact that the stripping theory for thin targets predicts a narrow maximum at 0-5Ed, and thick target effects shift the maximum downward in energy to approximately 0-4Ed. A number of recent spectral measurements are in agreement with these predictions for a wide range of target materials and incident deuteron energies. The application of this theory also accounts for the previously observed Dd2-99 dependence of the absorbed dose in tissue,per unit charge of D+ ions on target, in the direction of the incident beam. This approximate Ed3 dependence is shown to be a characteristic property of deuteron stripping in a thick target and follows directly from the calculations that predict the neutron energy spectrum.

Beryllium