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Biomedical subjects

F H Chow

Publications and source records attributed to F H Chow.

16 recordsLinked to original sources
PubMed1980

Effect of dietary calcium, magnesium, and phosphorus on phosphate urolithiasis in rats.

Female Wistar rats were fed a basal diet containing various concentrations of calcium, phosphorus, and magnesium: calcium and phosphorus at 0.4, 0.5, 0.8, 1.0, 1.5, and 2 per cent and magnesium at 0.2, 0.4, 0.8, and 1 per cent of the diet dry matter. Two types of uroliths developed: magnesium phosphate in the renal pelves, bladders, and/or ureters of rats fed rations containing 1 per cent magnesium with either 1.0 or 0.5 per cent phosphorus and calcium phosphate uroliths in the renal tubules at the corticomedullary junction of rats fed rations containing phosphorus equal to or greater than 0.8 per cent and magnesium equal to or less than 0.8 per cent. The incidence and severity of calcium phosphate uroliths were reduced by increasing the magnesium concentration in the diet from 0.2 to 0.8 per cent and by increasing the calcium-to-phosphorus ratio to greater than 1. Results of this study indicated that the interactions among dietary calcium, magnesium, and phosphorus seemed to affect the incidence, severity, and type of uroliths in rats.

Animals↗
PubMed1978

Oxalate (Rumex venosus) poisoning in cattle.

Fifteen range cows died of oxalate poisoning caused by ingestion of Rumex venosus. Ecchymotic and petechial hemorrhages were prominent on the abdominal serosal surfaces. Approximately 2 L of thin, yellowish fluid was in the abdominal cavity, and mesenteric lymph nodes were enlarged and edematous. Other findings included catarrhal abomasitis; enteritis; pale, edematous kidneys; congested lungs; fatty infiltration of the liver; and nephrosis. In the kidneys, birefringent crystals resembling oxalate crystals were demonstrable only when frozen sections were examined.

Animals↗
PubMed1978

Prevention of oxalate urolithiasis by some compounds.

Male Wistar rats were fed a basal diet, Purina Laboratory Chow, and an oxalate calculi-producing diet (CPD). The CPD was the basal diet containing 3 per cent glycolic acid. Sodium pyruvate, DL-alanine, alpha-keto glutaric acid, thiamine pyrophosphate, and L-glutamic acid were added to the CPD to determine their effectiveness in preventing calculi formation. The effectiveness of methyl glyoxal was determined by adding it to the drinking water. Rats fed CPD for 4 weeks developed calculi in the ureters, bladder, renal tubules, and/or renal pelvis and papilla. Rats in groups fed alanine and/or pyruvate had no calculi in their renal tubules or ureters; additionally, these rats had a significant reduction in incidence and amount of deposits in the renal pelvis and bladder. Rats in groups fed alpha-keto glutaric acid, thiamine pyrophosphate, L-glutamic acid, and methyl glyoxal developed equally or more severe oxalate urolithiasis than those on CPD alone. Results of this study show that either pyruvate or alanine at appropriate levels may be beneficial in preventing oxalate urolith formation.

Alanine↗