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Biomedical subjects

F H Prskavec

Publications and source records attributed to F H Prskavec.

At least 19 recordsLinked to original sources

Reversible changes of visual acuity and pattern-electroretinograms after blue-green argon laser photocoagulation of diabetic patients.

Visual acuity, color vision, pattern-visual-evoked-potentials (P-VEPs) and pattern-electroretinograms (P-ERGs) were measured in 13 diabetic subjects before, and 24 hours and 5 weeks after blue-green argon laser treatment. As control, the same examinations were performed in 7 normal subjects and 7 diabetic patients before and after slit lamp examination with the Goldman three mirror contact lens. Visual acuity and P-ERG amplitudes were significantly reduced one day after the laser treatment, while 5 weeks after the laser coagulation, visual acuity and P-ERG amplitudes recovered to pretreatment values. The control group showed no significant changes after slit lamp examination. Since fluorescein angiography revealed no macular changes after laser treatment, the possibility of a reversible functional light damage after blue-green argon laser coagulation (ALC) is discussed.

Aged

[Ocular findings in hemodialysis and following kidney transplantation in childhood and adolescence].

Between August 1980 and January 1987, 23 patients undergoing treatment for chronic renal failure underwent eye examinations. Hemodialysis and subsequent kidney transplants were performed in 18 patients; in two patients a kidney transplant was performed alone, and in three others hemodialysis without transplant. The interval between dialysis and transplantation averaged 23.1 months, the mean follow-up after transplantation 20 months. Patients who underwent hemodialysis alone were followed up for periods of two, three and 85 months. The patients' ages when hemodialysis treatment was first instituted ranged from six to 17 years (average 11.8 years). The mean age at the time kidney transplants were performed was 13.6 years (ranging from one to 17 years). Seventeen patients had conjunctival and corneal infiltrations in the area of the palpebral fissure. In two cases infiltrations were confined to the conjunctiva. Four patients had no pathologic changes, in either the cornea or the conjunctiva. Slitlamp examination revealed subcapsular losses of lens transparency in eight patients; these losses were manifested by delicate punctiform and patchy configurations. In nine cases fundus ophthalmoscopy revealed constricted retinal arteries. Within the period of observation all but one of the patients had unchanged vision. The one exception (cystinosis) had reduced visual acuity due to an accumulation of crystalline inclusions in the cornea.

Adolescent

[Long-term ophthalmologic follow-up of diabetic children].

Sixty-four infant diabetics were kept under observation for an average of 6.1 years to obtain ophthalmologic and endocrinologic data (biomicroscopic fundus examination, fundus photography, fluorescein angiography; blood sugar level, HbA1c determination, ketoacidosis, microalbuminuria, HLA-DR typing). In 28 patients (44%, Group B) retinal vascular changes corresponding to the picture of diabetic preretinopathy were detected by fluorescein angiography. In 36 children (56%, Group A), the retinal vascular system was normal. In 16 patients vascular anomalies increased during the observation period, while in 12 patients no further changes were seen. On comparing the endocrinologic findings in the two groups, the only statistically significant difference was in the ketoacidosis values. A tendency to hypoglycemic attacks, as well as elevated HbA1c and microalbuminuria levels, was likewise more frequent in Group B. Aside from the typical distribution, HLA-DR typing revealed a considerable percentage of children with 1/4 localization in Group B only. It was not seen in any patient in Group A. These results give rise to the hope that HLA-DR typing will enable prognostic conclusions to be drawn concerning the time of onset and progression of diabetic retinal alterations in the future.

Adolescent

[Reconstruction of the medial canthal area and lower eyelid].

This paper presents the case report of a patient with an extensive tumour of the lower eyelid and the medial canthal area treated by a combination of two surgical procedures. We combined the method described by Hughes and modified by Smith--a tarsoconjunctival graft from the upper eyelid--for reconstruction of the canthal area with a Tenzel lateral rotation skin flap. The combination of these methods enables the transplanted part of the tarsal tissue to be kept relatively small, which reduces the risk of postoperative complications of the upper eyelid. Moreover, with the rotation flap it is possible to control the tension of the lower eyelid exactly. The postoperative result is satisfactory.

Aged

[Indications and results of cryotherapy of eyelid tumors].

Since 1980, 112 patients presenting with tumours of the eyelid were treated by cryotherapy at the First University Department of Ophthalmology in Vienna. In 103 cases, histological examination revealed basal cell epithelioma, in 7 cases spindle cell epithelioma and in 2 cases a naevus. There were 69 female and 43 male patients and the average age was 68 years. Tumour recurrence existed in 29 of these patients who had previously undergone surgical treatment or radiotherapy. The low temperatures required for cryotherapy are produced by the use of liquid nitrogen. Contact freezing was performed in cases of tumours of up to 8 mm diameter; larger tumours or those with an irregular surface were treated by spray freezing. Within a follow-up period of 5 years, 9% of the patients with basal cell epithelioma and spindle cell epithelioma experienced recidivation.

Basal Cell Carcinoma

[Retinal pseudothrombosis].

As opposed to florid diabetic retinopathy, pseudothrombosis in type I diabetics has a favorable prognosis and responds well to panretinal photocoagulation therapy. In the past decade eight cases of retinal pseudothrombosis were evaluated, treated and kept under observation at the department for diabetic eye complications of the 1st University Eye Clinic, Vienna. Photocoagulation therapy repeated at brief intervals halted progression in all cases and improved visual acuity. In the follow-up period (2-10 years) no further episodes of progression were seen.

Adolescent

[Long-term study following panretinal argon laser coagulation in proliferative diabetic retinopathy].

Fifty-eight Type I diabetics were followed up for a minimum of 5 years after panretinal argon laser coagulation in both eyes for proliferative diabetic retinopathy. During the course of this study, 18 patients were excluded because thorough follow-up examinations according to our systematic approach had become impossible. The results of this study indicate that successful photocoagulation depends essentially on the initial findings, on the type and extent of treatment as well as on regular and thorough follow-up examinations.

Adult

[Changes in the visual field and dark adaptation following panretinal photocoagulation in diabetic retinopathy].

Within the past 5 years panretinal photocoagulation was performed in both eyes of 36 patients (Type I diabetics) with proliferative retinopathy. The age of these patients was between 21 and 38 years. The average follow-up period was 3.6 years. The effects on visual acuity, visual field, and dark adaptation were examined: in 65.3% of the cases (47 eyes) visual acuity remained unchanged; in 34.7% (25 eyes) central visual acuity was reduced. Depending on the coagulation technique and the number of coagulates applied, the visual field narrowed in a more or less pronounced way. Moreover, in all patients the dark adaptation threshold was elevated after panretinal photocoagulation.

Adult

[Temporary silicone oil implantation following vitrectomy in proliferative diabetic retinopathy].

Report on 23 patients with proliferative diabetic retinopathy who underwent silicone oil implantation due to recurrent intravitreal hemorrhages following pars plana vitrectomy. Postoperatively, it was possible to perform panretinal laser photocoagulation without difficulty or haste. After an average period of 4 months, silicone oil was removed from 10 eyes. Subsequent hemorrhages in 4 of these eyes are due to diabetic retinopathy, not to silicone oil. In 6 cases, silicone oil removal is planned for the near future; in a further 7 cases, silicone oil removal has been postponed because of the potential danger of further traction retinal detachment.

Diabetic Retinopathy

[Fundus changes in hyperlipidemia].

Of a total of 26 patients with hyperlipidemia, 4 developed flat yellow patches of varying size and shape in the macular area. In a different study a total of 9 subjects with similar flat yellow patches were examined; 6 had increased levels of serum cholesterol and triglycerides. The likelihood that such patients have hyperlipidemia is well over 50%.

Aged

[Recurrence of vasoproliferative activity after photocoagulation. A fluorescence-angiographic study].

Although photocoagulation is no cure for diabetic retinopathy, it slows down or, in favourable cases, prevents further progression. In order to achieve the desired therapeutic effect, photocoagulation has to include the ischaemic mid-periphery of the retina. Following a latency period of varying duration during which no further progression is evident either on ophthalmoscopic examination or fluorescein angiography, recurrence of neovascularization is observed in some cases. The therapeutic management entails additional panretinal photocoagulation, in particular at the periphery. The authors report on 75 patients who, following panretinal photocoagulation, were treated by additional argon-laser coagulation.

Diabetic Retinopathy

[Light and electron microscopic findings in eyelid tumors after cryotherapy].

Over the past five years 112 patients underwent cryotherapy of lid tumours. Two methods of freezing, contact freezing and spray freezing, were used. Biopsy specimens for histological studies were taken before and after cryotherapy. The results of light and electron microscopy are reported. Electron microscopic examination shows that cryonecrosis exhibits the well known general characteristics of necrosis. Cryotherapy results in extensive tumour necroses and this fact explains the success rate of 90.9% in basalioma 5 years after therapy.

Adult

[Extracapsular cataract operation with implantation of posterior chamber lenses following fistulating glaucoma operations].

In 78 eyes treated by different fistulizing procedures (57 by goniotrepanation or trabeculectomy, 13 by Elliot trepanation and 8 by iridencleisis) extracapsular cataract extraction with implantation of posterior chamber lenses was performed. A sector iridectomy had to be performed in about 40% of the eyes because of difficulties in dilatation of the pupils and posterior synechiae. Postoperatively the IOP was regulated in 83% of all eyes without additional topical medication; a second fistulizing procedure was only necessary in one eye. Complications such as keratopathies, posterior capsule fibrosis, and dislocations of the posterior chamber lenses were not found to be more frequent compared with nonglaucomatous eyes treated by extracapsular cataract extraction with implantation of posterior chamber lenses.

Aged

[Initial clinical results on the problem of implantation of intraocular lenses in diabetes mellitus].

About 2% of the Austrian population suffer from diabetes mellitus, the incidence being higher in the 5th and 6th decades of life. As a consequence the number of diabetics requiring cataract surgery is relatively large. In recent years extracapsular cataract extraction with implantation of a posterior chamber lens has become the method of choice. The question under what circumstances implantation is indicated in diabetics and in which cases it is contraindicated is still under discussion. During the past 2 years extracapsular cataract surgery with implantation of a posterior chamber lens has been performed on 36 patients (42 eyes). The average period of observation ws 8.5 months. The patient material was analyzed in a retrospective study and the results of surgery are reported in this paper.

Aged

[Follow-up of central diabetic retinal changes following peripheral photocoagulation].

One eye of each of 27 patients suffering from preproliferative diabetic changes in the periphery of the retina was treated by panretinal photocoagulation; in the fellow eye photocoagulation was only performed in the peripheral zones of the fundus. Follow-up observations over an average period of 1.5 years showed a centripetal progression of capillary obliterations in only 5 eyes after peripheral photocoagulation and a less pronounced tendency to development of a diabetic maculopathy as compared to eyes treated by panretinal photocoagulation.

Adult

[Clinical experience with cryotherapy of lid tumors (author's transl)].

Eleven patients with lid tumors underwent cryotherapy. Of these, six suffered recurrence of the tumor following surgery or radiotherapy, respectively. The patients' average age was 66.1 years. The temperatures required for cryotherapy were obtained with fluid nitrogen. Two possible modes of treatment may be distinguished. In contact freezing (used in eight cases) the cryoapplicator is in direct contact with the surface of the tumor. In the second method, spray-freezing (used in three cases), fluid nitrogen is sprayed at a certain pressure directly on to the surface of the tumor. In all cases treatment was performed on outpatient basis. The indications for treatment, the technique applied and the results obtained hitherto are presented.

Adult