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Biomedical subjects

F H Sørensen

Publications and source records attributed to F H Sørensen.

At least 19 recordsLinked to original sources
PubMed1997

Effects of age on anal function in normal women.

PURPOSE: To study effects of age on anal function in healthy women. METHODS: A study of 75 women with no known anorectal disease, aged 20 to 83 (mean 50) years, mean parity 2 (range 0-4). Perineal position at rest (PR), descent during straining (PS), maximum resting pressure (MRP) maximum squeeze pressure (MSP) of the anal sphincters, and pudendal nerve terminal motor latency (PNTML) were measured. Data were analysed using the multiple regression technique including age and parity in the model. RESULTS: Increasing age was significantly associated with a weakening of anal function. PR and PS were both lowered (P < 0.0001 and P = 0.0001). Anal sphincter pressures were reduced (MRP: P = 0.004, MSP: P = 0.015), and age was associated with an increased mean PNTML (P < 0.0001). All associations seemed to be linear. Parity was associated with a lowering of both PR and PS but not with the other parameters. Age accounted for 13-44% of the total variability seen in the tests of pelvic floor function. CONCLUSION: Age leads to a consistent reduction in anal function and this is likely to increase the risk of faecal incontinence in old age. From the current data we suggest that in normal women with an uncomplicated obstetric history increasing age is associated with significant changes in anal function whereas long-term effects of vaginal deliveries play a minor role. Moreover our results suggest gradual changes throughout adult life, rather than large changes occurring after menopause.

Adult↗
PubMed1996

[Results of ileoanal reservoir surgery].

We report our surgical, late complications and functional outcome of 157 consecutive restorative proctocolectomies with an ileoanal J pouch at the Department of Surgery L, Arhus City Hospital. Nine patients had familial adenomatous polyposis, while 148 patients were operated for ulcerative colitis. All patients had a protecting ileostomy. There was no mortality. Surgical complications after J pouch: Six patients were reoperated, five due to intra-abdominal bleeding, one for ileus. There was only one pelvic abscess, and it was drained percutaneously. There were no fistulae, no anastomotic leakage and no early pouch removal. Surgical complications after ileostomy closure: Eight patients were reoperated; two due to wound infections, five for ileus and one due to a wound rupture. Late Complications: Four pouches were removed, due to incontinence, difficult evacuation, chronic pouchitis or Crohn's disease. There were three late pouchovaginal fistulae more than one year after surgery. Five patients had surgery for ileus, one for an intra-abdominal abscess, one for a perianal fistula and eight for incisional hernia. Functional outcome: One year after pouch surgery more than 90% of patients were satisfied with the operation, 2.2% had regretted and 3.6% were in doubt. The functional result was satisfactory in the majority of the patients, but 21.1% had one or more night evacuations and 13.9% had variable degrees of incontinence.

Adenomatous Polyposis Coli↗
PubMed1993

[Blood transfusion increases the risk of surgical infection].

In a prospective randomized trial the frequency of infectious complications and natural killer cell function were investigated in 197 patients undergoing elective colorectal surgery and having either no blood transfusion (n = 93), transfusion with whole blood (n = 56), or filtered blood free from leucocytes (n = 48). Postoperative infections developed in 13 patients transfused with whole blood (23%), in one patient transfused with blood free from leucocytes (2%) and in two non-transfused patients (2%) (p < 0.01). Natural killer cell function was significantly (p < 0.001) impaired up to 30 days after surgery in patients transfused with whole blood. These data provide a strong case against the use of whole blood transfusion in patients undergoing elective colorectal surgery.

Adolescent↗
PubMed1983

Protective effect of implanted autologous splenic tissue in splenectomized rats exposed to i.v. Streptococcus pneumoniae.

The protective effect of splenic implantation or hemisplenectomy on the survival rate was studied in 34 Wistar rats inoculated intravenously with 8.5 x 10(6) CFU Streptococcus pneumoniae type 25, 4 months prior to the bacterial challenge, different surgical procedures were performed, dividing the animals into 5 equally large groups: (1) sham operation, (2) hemisplenectomy, (3) splenectomy with a 100% reimplantation, (4) splenectomy with a 50% reimplantation, and (5) splenectomy without reimplantation. The observation period after the bacterial inoculation was 13 d. Differences in mean survival rates were found: (1) 13 d, (2) 10.6 d, (3) 7.1 d, (4) 5.6 d, and (5) 3.1 d. The increasing survival rates correlated with increasing weights of the residual splenic tissue. This animal study indicates that residual splenic tissue may account for a lesser tendency to infection.

Animals↗
PubMed1983

A predictor analysis of clinical assessment of outcome among patients operated on for duodenal ulcer. A 1-year prospective study.

During a period of 1 year, data concerning life events, non-specific psychological symptoms, individual social history, and ulcer history were obtained for consecutive cases of patients about to have elective surgical treatment for duodenal ulcer. At the 1-year follow-up examination a blind, clinical evaluation was performed (dumping, dyspepsia, recurrence, and Visick grading), and information concerning the 94 patients' assessment of outcome was obtained. A multivariate predictor analysis was performed. Most patients (85%) benefited from treatment. The excess rate of non-specific psychological symptoms indicating impairment remained unchanged. The patients assessments of outcome were correlated with the clinical assessment. A positive correlation was found for women to have dumping and poor Visick grade and for unmarried persons to have postoperative dyspepsia and a poor Visick grade. A negative correlation between a long ulcer history and postoperative dyspepsia and a positive correlation between pyloroplasty and dumping were found. Non-specific psychological symptoms predicted poor clinical assessments. It is suggested that it is relevant to apply the patients' assessments for the purpose of evaluation, supplementing the clinical assessment of the more biomedical aspects of outcome.

Adult↗
PubMed1983

The value of parietal cell vagotomy compared to simple closure in a selective approach to perforated duodenal ulcer. Operative morbidity and recurrence rate.

Of 168 consecutive patients presenting with a perforated duodenal, pyloric or prepyloric ulcer, 123 patients were judged fit or suitable for parietal cell vagotomy (PCV). It was, however, only added to simple closure in 67 patients with a previous history of dyspepsia prone to develop recurrent ulceration, whereas 56 patients with no previous symptoms and an established low risk of recurrence were managed by simple closure only. In the comparable groups, postoperative morbidity did not differ, entailing mortality rates of 4.5% and 5.3% following PCV or simple closure only. An overall clinical grading of 106 patients (91%) followed up (median 4 years, range 1-10 years) revealed equally good results. In patients with previous dyspepsia and an established high recurrence rate if managed by simple closure only, a satisfactory reduction of the recurrence rate was found when PCV was added to suture closure (cumulative recurrence rate 20.7 +/- SD 69 compared to 29% +/- SD 9.4 following simple closure in patients with no previous dyspeptic symptoms). It is concluded that in patients with a perforating duodenal ulcer deemed fit or suitable for PCV, assessed by good clinical judgement, PCV does not carry an added risk and provides a fairly good protection against recurrent ulceration.

Adolescent↗