PubMed Health⌕ Search

Biomedical subjects

F H Sennhauser

Publications and source records attributed to F H Sennhauser.

40 records · Page 3Linked to original sources
PubMed1988

Short-time response characteristics of salbutamol in infants with broncho-pulmonary diseases.

The effects of salbutamol 0.225 mg/kg given systemically on lung function in infants have been measured by whole-body plethysmography in 60 children with broncho-pulmonary diseases (24 after respiratory distress syndrome, 21 with wheezy bronchitis and 15 with cystic fibrosis). A therapeutic action was demonstrated in 74% of the tests, taking into account changes in end-expiratory resting level (state of inflation) and associated changes in airway resistance. There was a significant decrease in thoracic gas volume as an estimate of pulmonary hyperinflation, which was due to improved alveolar ventilation and to a consequential decrease in end-expiratory resting level. The improvement in airway resistance, as an estimate of airway obstruction, reflects a substantial relaxation of bronchial smooth muscle increasing the diameter of the airways. The extent to which similar results may be achieved by topical administration of nebulised beta agonists remains to be determined.

Airway Resistance↗
PubMed1988

Anti-IgA antibodies in IgA-deficient children.

IgG and IgM isotype antibodies to polyclonal human IgA, myeloma IgA1, and myeloma IgA2 were estimated in 38 IgA-deficient children aged between 0.9 and 15 years. All children had IgM anti-IgA antibodies. IgG antibodies against either polyclonal IgA, IgA1, or IgA2 were present in 63% of the IgA-deficient children. IgG anti-IgA antibodies were detected against all three antigens in 8 of 11 severely IgA-deficient children and in 7 of 27 partially IgA-deficient children, but in only 1 of 23 healthy adult controls. The proportion of children with IgG anti-IgA antibodies was significantly greater in the severely IgA-deficient group in comparison with the partially IgA-deficient group and the adult controls (chi-square test, P less than 0.01 and P less than 0.005, respectively). There was a strong correlation within each IgG subclass between antibody responses toward each of the three IgA antigens. Twenty-four children were followed over a period ranging from 0.9 to 11 years (mean, 2.3 years). Three children who were initially IgG anti-IgA antibody negative became antibody positive and three who were antibody positive became antibody negative. Five children with severe IgA deficiency remained severely IgA deficient and IgG antibodies to IgA persisted in all five at follow-up. The presence of IgG anti-IgA antibodies did not influence the normalization of serum IgA at follow-up in 14 of 19 children who were initially partially IgA deficient.

Adolescent↗
PubMed1986

[Epidemiologic aspects of bronchial asthma in childhood].

Bronchial asthma was studied in 813 children subdivided into 5 etiopathogenetic groups by lung function tests performed in the symptomfree "interval phase" of the disease. The patients were followed up for a 5-year period (1980-1984). 56% had continuous perennial asthma, 24% seasonal asthma, 14% infection-induced asthma, 3% psychogenic asthma and 3% exclusively exercise-induced asthma. With regard to functional abnormalities, 32% of patients presented with values within the range of normal, 23% showed pulmonary hyperinflation (FRC greater than 130% predicted), 42% had bronchial obstruction (Raw greater than 130% pred.) and 3% showed restriction of static lung volumes (TLC less than 80% pred.). 91 patients with perennial continuing asthma have been followed up under regular anti-asthmatic treatment over 2 years, during which at least 3 lung function tests have been performed. The study shows that asthmatic children must be evaluated according to the kind and degree of functional abnormalities and within certain age groups. Best improvement after treatment, mainly by inhalation of beta-2-mimetrics and mastcell stabilisators, and partly also by topical steroids, was found in the age groups 8-10 years and 11-13 years respectively. In spite of treatment asthmatic children showed an increase in bronchial constriction in the 5-7 year age group and an increase in pulmonary hyperinflation in the 14-16 age group. These two age groups seem to represent vulnerable periods in the development of childhood asthma which are determinant for the later prognosis.

Adolescent↗