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Biomedical subjects

F Hackenberger

Publications and source records attributed to F Hackenberger.

15 recordsLinked to original sources
PubMed1986

[Availability of propylphenazone from suppositories. 2. Bioavailability].

The examination of the bioavailability from 4 different preparations of propyphenazone suppositories on a fatty base, studied in 10 healthy volunteers, showed bioequivalence as was judged by means of the AUC-values. Aminophenazone suppositories of an equivalent dosage led to significant higher values of plasma concentrations if compared with propyphenazone. The in vivo findings correlate with in vitro results of availability.

Adult↗
PubMed1981

[The bioavailability of trapidil from suppositories (author's transl)].

In a study with five healthy persons designed to compare the bioavailability of Trapidil from Rosupol U suppositories with that from Witepsol H 15 suppositories, the availability of Trapidil from the Rosupol U suppositories was inferior in four of the five test subjects. The difference in the amounts of released drug observed in vivo was smaller than that found in vitro.

Adult↗
PubMed1975

[Clinical and experimental examinations of drug-aerosols for the practice (author's transl)].

Drug examination is regulated by drug legislation and special instructions for examination methods. Drug aerosols and inhalants for therapeutic purposes have to been examined regarding the different liquids, solutions, carriers and technical devices such as nozzles, ultrasonics and propellants for administration as a nebulized aerosol. Indications and contraindications of these inhalants, their local compatibility and reactions to the bronchial mucosa, their desired therapeutic effects, localized and general side-effects, localized and general side-effects have to be determined and are discussed. The data of these examinations have to be correlated with clinical and paraclinical results.

Aerosols↗