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Biomedical subjects

F Hadziselimović

Publications and source records attributed to F Hadziselimović.

30 records · Page 2Linked to original sources

Hormonal treatment of cryptorchidism.

60 cryptorchid boys (39 unilateral and 21 bilateral) aged between 10 months and 14 years were treated by conservative methods. All boys received an initial therapy of 200 micrograms GnRH nasal spray (decapeptide) in each nostril three times daily for 4 weeks. Those who did not respond favorably to the GnRH treatment immediately received a follow-up therapy with 1,500 IU or boys over 7 years 2,000 IU of HCG per week for a total of 3 weeks. Immediately after completion of this therapy, the success rate was 80% (65/81 testes descended). 6 months afterwards 6 of the 48 testes suffered a relapse. Thus, 73% of the testicles were still descended 6 months after completion of therapy.

Adolescent↗

Transmission and scanning electron microscopy of epididymis in male mice receiving estrogen during gestation.

In estrogen-induced cryptorchidism in mice, differentiation of the epididymis is arrested. Transformation of the Wolffian duct into the epididymis, which is androgen dependent, is incomplete. Simultaneous administration of estrogen and HCG prevents cryptorchidism, and the appearance of the epididymis in the transmission and the scanning electron microscope is similar to the appearance of the epididymis of control animals. According to our studies the epididymis differentiation is a prime mover in a process which leads to the descensus of the testis.

Animals↗

The role of the epididymis in descensus testis and the topographical relationship between the testis and epididymis from the sixth month of pregnancy until immediately after birth.

The position of the testis, the relationship between the epididymis and the testis, as well as the development and regression of the gubernaculum were investigated in 18 testicles of children from the 26th week of pregnancy until a few weeks after birth. The most important role in descensus testiculorum is ascribed to the differentiation of the epididymis and the ductus deferens. It is androgen dependent. The testis descends in the processus vaginalis, being attached to its dorsal wall.

Epididymis↗