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F Hadziselimovic

Publications and source records attributed to F Hadziselimovic.

47 records · Page 3Linked to original sources
PubMed1977

Pathogenesis of cryptorchidism.

Cryptorchidism was induced experimentally by treating pregnant mice on the 14th day of pregnancy with 5 mg estrogen. Testes from cryptorchid and control newborn and adult mice were investigated with radioimmunoassay and electron microscopy. It was concluded that a normal Leydig cell function plays a decisive role in testicular descent. In cryptorchidism, Leydig cells at birth are atrophic. Testicular testosterone content is diminished as compared to controls. Ultrastructural alterations of Leydig cells observed in our experiments closely resemble those found in biopsies of cryptorchid patients. In male mouse offspring, prenatal estrogen injection induced not only a cryptorchidism but also Leydig cell atrophy and a permanently impaired function. Testosterone content is still significantly diminished after puberty. It is proposed therefore that an insufficiency of endocrine gonadal function of hypothalamo-pituitary origin occurring during intrauterine development is one of the main causes of cryptorchidism. An appropriate long-term therapy could diminish the high sterility rate.

Age Factors↗
PubMed1976

The meaning of the Leydig cell in relation to the etiology of cryptorchidism: An experimental electron-microscopic study.

In our electron-microscopic studies of testicular biopsies, both normal and cryptorchid, we found a simple atrophy of the Leydig cell in the cryptorchid testis. Based on experiments by Raynaud1,2 and Jean3 on pregnant mice, we tried to find the reason for changes in the Leydig cell relating to the etiology of cryptorchidism. We found on electron microscopic study of testes in the offspring of pregnant mice treated with estrogen the same atrophy of the Leydig cell as we see in human cryptorchidism. These changes are not evident when estrogen and HCG are given together. We can conclude from this experiment that lack of gonadotropin stimulation leads to the atrophy of Leydig cells. This atrophy then produces a lack of androgen which could be responsible for cryptorchidism.

Androgens↗
PubMed1976

[Electron microscopic study of the development of the seminiferous tubule from birth to the end of the 1st year].

The development of the seminiferous tubule in the first year of life was studied with the electron microscope in five biopsies of normal testes. When HCG stimulation ceases, the fetal Sertoli cell changes into the Sa-Sertoli cell. The possibility of the fetal Sertoli cell having a hormone producing role is discussed. Gonocytes can be detected until the third month post natum. In addition to the gonocytes fetal, transitional, Ap and Ad spermatogonia are also present in the first year of life.

Chorionic Gonadotropin↗
PubMed1975

Surgical correction of cryptorchism at 2 years: electron microscopic and morphometric investigations.

Electron microscopic and morphometric investigations on undescended testicles show a decreased volume density of the spermatogonia up to the age of 5 (approximately 60%, p smaller than 0.005), corresponding to investigations by light microscopy. There are no ultrastructural differences in the seminiferous tubules between normal and undescended testicles up to the age of 1 yr. There are ultrastructural changes of Leydig cells within the first year of life. Based on these investigations, we conclude that the optimal time for surgical intervention in case of undescended testes is in the second year.

Age Factors↗
PubMedDate not supplied

Influence of breast milk on nosocomial rotavirus infections in infants.

To prevent nosocomial rotavirus infections in hospitalized children with various non-gastrointestinal diseases, 30 children (mean age five months) received 200 ml of fresh human milk per day in addition to the normal diet for their age. A matched group of children on formula diet served as a control. Fecal samples were routinely screened for rotavirus by a commercial ELISA test. In stools containing rotavirus, the virus RNA segments were analysed by gel electrophoresis to identify the different rotavirus strains. Clinical symptoms were recorded daily and quantified by a score system. Human milk had no effect on the frequency of nosocomial rotavirus infections: ten infected children were fed with human milk and seven were not. However, the severity of the clinical symptoms was clearly reduced: the mean score of clinical symptoms was only half as great and the number of mild or asymptomatic infections was doubled in the group receiving fresh human milk.

Cross Infection↗
PubMedDate not supplied

[Cryptorchidism: pathogenesis and histology].

An impairment of the hypothalamopituitarygonadal axis was found to be the main cause of undescended testicles in 80 per cent of patients. Basing himself on personal observation, the author develops the theory that the mechanism of testicular descent is the stimulation by GnRH of the pituitary gland to release gonadotrophins, which in turn stimulate the interstitial cells to secrete testosterone. High local testosterone concentration fosters the development of the differentiating portion of the mesonephric duct into the epididymis. The epididymis induces descent by pushing rather than pulling the testis into the scrotal position. Any interference with this mechanism during the embryonal life leads to cryptorchid testes, which, in the vast majority of cases are localized at the external inguinal ring. The earlier the scrotal position is reached, the greater the chances of subsequent fertility.

Cryptorchidism↗