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Biomedical subjects

F Hartmann

Publications and source records attributed to F Hartmann.

At least 145 records · Page 8Linked to original sources
PubMed1986

Activation of latent collagenase from polymorphonuclear leukocytes by oxygen radicals.

Polymorphonuclear leukocytes (PMN) accumulating at inflammatory sites have the potential to degrade collagen by releasing the metalloproteinase collagenase (EC 3.4.24.7), which is stored within the specific granules of these cells in a latent, inactive, form. In order to elucidate the activation mechanism the latent enzyme (molecular weight 91,000) was purified from human PMN and incubated with the oxygen radical-generating system of xanthine oxidase (EC 1.1.3.22) and hypoxanthine. This coincubation resulted in the activation of the latent enzyme as assessed by the collagenolytic attack on human and bovine cartilaginous tissue. Two parameters for collagenolysis were used: loss of hydroxyproline-containing fragments, and mechanical measurements reflecting the stability of tissue specimens. Superoxide dismutase (EC 1.15.1.1) as well as catalase (EC 1.11.1.6) were capable of inhibiting the activation of latent PMN collagenase by the oxygen radical-generating system. The results indicate the hydroxyl radical to be the final oxidant responsible for the activation of latent PMN collagenase. Thus a new activation mechanism of latent collagenase is presented in this paper and discussed together with the potential relevance in pathophysiologic states of acute and chronic inflammation.

Animals↗
PubMed1985

[Not Available].

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History, Modern 1601-↗
PubMed1985

[Apropos of a case of sleep hypochondriasis].

About one case of an important sleeplessness for 4 years, the authors show the characteristics of this moan, which they would want to call it "Sleeping hypochondria". This hypochondria is very "efficient" because the sleeping quality is always subjective. More, patient and therapeut especially invest it. Oftenly, hypnotics are ordained. In this case, the confusion between offered and real symptoms could be grown. In fact, the last one is the patient moan, his speech subject. The treatment of this particular case, by paradoxical injunction, allowed to create a breaking of the patient system. The paradoxical cure, by made-self prescription, allows to understand much better the "insomnia work" in the aggressive relationship with the therapeut.

Adult↗
PubMed1984

Mitoxantrone metabolism in the isolated perfused rat liver.

The hepatobiliary pharmacokinetics of mitoxantrone, a new anthracenedione derivative, was studied in the isolated perfused rat liver. Mitoxantrone was administered in doses of 0.2 and 0.4 mg/kg body weight. Multiple bile samples were obtained for 4 hours. Mitoxantrone and three metabolites were separated by high-performance thin-layer chromatography (HPTLC) and measured at 610 nm. Following 0.2 mg mitoxantrone/kg body wt, 25.8% +/- 2.6% of the administered dose was excreted in the bile during 4 h, the major metabolite M1 accounting for 80% of this. After 0.4 mg mitoxantrone/kg body wt the amounts excreted were lower and light microscopic examination showed disseminated areas of cell necrosis.

Animals↗
PubMed1984

The corporeality of shame: Px and Hx at the bedside.

In order to appreciate the role of the phenomenon of shame in the context of the clinic - both as normal self evaluation and as neurotic response - a philosophical anthropological description of shame is offered. Not only are Biblical metaphors recast , but more recent phenomenological psychological descriptions taken from Max Scheler and others are cited. These necessarily require some account of the patient's body in shame, taken from both his perspective and the physician's. In short, the corporeality of shame is constituted as "ce que enveloppe le corps".

Guilt↗
PubMed1984

Biomechanical properties of human intervertebral discs subjected to axial dynamic compression. A comparison of lumbar and thoracic discs.

This investigation revealed biomechanical properties and some morphological parameters of isolated intervertebral discs at various disc levels. One hundred twenty-three specimens were subjected to axial dynamic compressive loads. The duration of testing was 5 minutes, the loads Fd1 = 650 N +/- 400 N (discs from T5-6 to L1-2) and Fd2 = 950 N +/- 540 N (discs from T9-10 to L5-S1). Down the spine, the mean disc heights and cross-sectional areas increased; the water content seemed to be nearly constant. Axial deformation and ventral bulging increased down the spine as well, which is mainly due to the increasing disc height. Creep showed different characteristics. It was smallest within the region T10-11 to L1-2 and increased above and below this level. The increase below L1-2 is mainly due to the increasing disc height; the increase above T10-11 occurs because the thoracic discs behave in a more viscous manner than the lumbar discs.

Adolescent↗
PubMed1984

Biomechanical behavior of human intervertebral discs subjected to long lasting axial loading.

48 lumbar discs were tested; the creep tests lasted between 2 and 6 hours. All discs showed the known creep behavior, i.e. a decrease of height, rate of creep and axial deformability with time. In the first minutes of a test the viscoelastic behavior quickly alters so that the disc behaves more like an elastic body. Loss of mass normally observed after creep tests is due to loss of water. Creep behavior is reproducible if a disc has sufficiently recovered, i.e. if it has regained its initial height. Creep tests on "desiccated" discs revealed that creeping is possible without loss of water and recovery is possible without absorption of water. The type of loading (static or dynamic) has hardly any influence on the biomechanical behavior. Our results indicate, that creep and recovery are chiefly due to extension and contraction of the anular fibers and not to fluid flow.

Adolescent↗
PubMed1982

Adrenocortical function of rats under prolonged administration of lipidosis-inducing drugs.

The influence of three potent lipidosis-inducing agents, i.e. iprindole, triparanol and chloroquine, on the rat adrenal cortex was investigated by determination of the corticosterone excretion in the urine, the responsiveness to ACTH and by determination of the corticosterone content of the adrenals and of the corticosterone concentration in plasma. Administration of iprindole and triparanol left the function of the adrenal cortex unaffected, while under chloroquine treatment an activation with time was observed. Morphologically, similar degrees of lipidosis were found in all experiments. The results demonstrate that the functional capacity of the rat adrenal cortex is not directly correlated to lipidotic alterations.

Adrenal Cortex↗