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Biomedical subjects

F Hasse

Publications and source records attributed to F Hasse.

8 recordsLinked to original sources
PubMed1998

[Treatment of chronic acetabular pelvic osteomyelitis after alloprosthetic hip joint replacement with a gluteus maximus flap].

We report on a 65-year-old man who was sent to our clinic with osteomyelitis of the hip combined with a chronic external fistula after hip joint replacement followed by several further operations including amputation of the leg. After complete removal of the fistula and repeated vacuum sealing of the wound, we used a vasculated glutaeus maximus muscle flap to close the defect. The course after the operation was without any complications. The method applied led to sufficient treatment of the osteomyelitis without weakening the trunk muscles or rendering the use of crutches more difficult.

Acetabulum↗
PubMed1996

[Comparison of liver resection with sequential transarterial chemoembolization in stage pT3 or pT4 hepatocellular carcinoma].

Between January 1990 and January 1996, 39 consecutive patients with histologically improved pT3 or pT4 HCC tumors underwent curative resection (n = 19) or sequential transarterial chemoembolization (n = 20) with a median time interval of 7 weeks up to six times with an emulsion of Lipiodol, Epirubicin and Cisplatin. The 30-day mortality rate for all sessions of TA was 3.8% vs. 21.8% in the resection group (p < 0.05); the cumulative survival rate for the embolization group at 6, 12, 18 and 24 months was 72.3%, 50.1%, 41.2%, 35.4% vs. 42.1%, 31.6%, 31.6% and 14.2% following resection, which cannot be considered statistically significant. Patients with T3 and T4 HCC, treated with sequential embolization or resection, seem to have a comparable survival time.

Carcinoma, Hepatocellular↗
PubMed1994

A procedure for the determination of 5-fluorouracil in tissue using microbore HPLC and fluorescence detection.

For the determination of the cytotoxic drug 5-fluorouracil in tissue, a sensitive and selective assay has been developed based on microbore high-performance liquid chromatography and fluorescence detection after pre-column derivatization with 4-bromomethyl-7-methoxycoumarin. 5-Chlorouracil was found to be an appropriate internal standard. A column switching protocol has been devised to separate the analyte from late eluting matrix components and the natural uracil. The drug can be determined at concentrations in the low ng/g wet tissue range with a detection limit of 3 ng/g; furthermore, the same protocol can be applied to analyze serum and plasma samples. The procedure was employed to determine the drug in samples taken from human liver tumors and metastases after an intra-arterial bolus administration and from epithelial carcinomas after systemic continuous application.

Calibration↗
PubMed1990

[Learning from mistakes. Thoughts on preclinical care of accident victims based on 10-year experience in a large city of West Germany].

On the occasion of the 25th anniversary of preclinical emergency medicine a review of the last decade of preclinical treatment of polytraumatized patients was performed. Initially preclinical emergency medical services were established for the immediate care of victims in road accidents. Therefore these services were first usually stationed in Centers for Surgery or Traumatology. Emergency physicians in these were inevitably well trained in the emergency treatment of trauma patients. The Achilles tendon then was their limited ability to cope with differentiated internal problems. Whereas the quality of preclinical treatment in non-traumatic emergencies gradually increased during the last 10 years due to compulsory postgraduate training courses and due to the fact, that the percentage of physicians and anesthetists among the emergency crews also gradually increased, the average emergency physician no longer possessed enough practical experience with the early treatment of trauma patients, a disadvantage, which could not be sufficiently compensated in compulsory postgraduate training courses. This could be demonstrated in our 10 year quality control. Only physicians of Search and Rescue helicopter teams and residents of surgical and trauma departments made significantly few mistakes in the early treatment of polytraumatized patients. Typical mistakes of less experienced physicians could be sorted into 5 groups: --volume treatment: incorrect estimation of the severity of polytrauma/incorrect estimation of the amount of blood loss/insufficient substitution of volume/logistical mistakes. --O2 treatment: incorrect estimation of the degree of blunt thoracic trauma/hesitant indication for early artificial respiration/hesitant indication for thoracic drainage. --local treatment: incorrect estimation of the severity of soft tissue trauma/incorrect treatment of amputated limbs. --logistics and transport: additional iatrogenic laceration of soft tissues due to insufficient reposition and retention/logistical mistakes in choosing in the best means of transport and the best suited hospital for the patient. --special types of trauma: incorrect estimation of the severity of burn trauma/lack of experience in triage in cases of major accidents. To get better results in the early treatment of polytraumatized patients, the installation of a specialized emergency medical service for trauma patients in the main trauma centers of major cities combined with the function of the surgeon in charge for major accidents and catastrophies is to be discussed.

Diagnostic Errors↗
PubMed1985

Rupture of a thoracic aortic aneurysm after prosthetic bypass from the ascending aorta to the descending aorta in a case of congenital aortic arch hypoplasia.

An unusual case of a successfully operated ruptured thoracic aneurysm of the aorta with bleeding into the atelectatic pulmonary left lower lobe and acute occlusion of the prosthesis in a 28-year-old woman is reported. The underlying disease was congenital aortic arch hypoplasia still present following implantation of a prosthetic bypass from the ascending aorta to the descending aorta performed in 1963.

Adult↗
PubMedDate not supplied

Sequential transarterial chemoembolization for unresectable advanced hepatocellular carcinoma.

PURPOSE: The aim of this prospective study was to evaluate the feasibility, safety, and efficacy of sequential transarterial chemoembolization (TACE) for patients with unresectable advanced hepatocellular carcinoma (HCC). METHODS: Twenty-one consecutive patients with unresectable T3 and T4 HCC were treated by sequential TACE (median time interval between treatments 7 weeks) up to six times with an emulsion of lipiodol, epirubicin, and cisplatin. All TACE procedures were performed as unilobar or whole-liver chemoembolization. RESULTS: An average of 3.9 TACE procedures were performed per patient. One primary and two secondary technical failures occurred. No procedural death was observed. After exclusion of the patient with the primary technical failure and 3 patients with extrahepatic disease, the survival rates for the remaining 17 patients at 6, 12, 18, and 24 months were 70.6%, 52.9%, 44.1%, and 33.1%, respectively. CONCLUSION: Sequential TACE is a safe procedure in patients with unresectable advanced HCC and feasible in most cases. It seems to prolong the survival time compared with historical series of untreated patients.

Adult↗